Penyakit Alzheimer minangka kelainan neurodegeneratif progresif sing utamane mengaruhi otak, nyebabake mundhut memori, penurunan kognitif, lan owah-owahan prilaku.
Penyebab penyakit Alzheimer sing tepat ora dingerteni kanthi lengkap, nanging dipercaya minangka asil saka kombinasi faktor genetik, lingkungan, lan gaya urip.
Sawetara faktor sing bisa nyumbang kanggo pangembangan penyakit Alzheimer kalebu:
1. Genetika: Gen tartamtu wis diidentifikasi sing nambah risiko ngembangake penyakit Alzheimer, utamane gen apolipoprotein E (APOE).
2. Umur: Risiko ngembangake penyakit Alzheimer mundhak kanthi umur, lan umume wong didiagnosis sawise umur 65 taun.
3. Riwayat kulawarga: Duwe riwayat kulawarga penyakit Alzheimer bisa nambah risiko ngembangake kahanan kasebut.
4. Cedera sirah: Riwayat cedera sirah, utamane sing nyebabake kelangan kesadaran, bisa nambah risiko penyakit Alzheimer.
5. Faktor risiko kardiovaskular: Kahanan kayata tekanan getih dhuwur, kolesterol dhuwur, lan diabetes bisa nambah risiko ngalami penyakit Alzheimer.
6. Faktor gaya urip: Gaya urip sing ora aktif, panganan sing ora apik, lan kurang stimulasi mental bisa nambah risiko penyakit Alzheimer.
7. Peradangan: Peradangan kronis ing otak bisa uga nyumbang kanggo pangembangan penyakit Alzheimer.
8. Stres oksidatif: Ketidakseimbangan antarane produksi radikal bebas lan kemampuan awak kanggo detoksifikasi bisa nyumbang kanggo pangembangan penyakit Alzheimer.
9. Plak amiloid lan tangles neurofibrillary: Akumulasi plak amiloid lan tangles neurofibrillary ing otak minangka ciri khas penyakit Alzheimer, nanging peran sing dimainake ing pangembangan kahanan kasebut ora dingerteni kanthi lengkap.
Penting kanggo dicathet manawa panyebab penyakit Alzheimer rumit lan bisa uga kalebu kombinasi faktor kasebut.
Riset terus-terusan kanggo luwih ngerti mekanisme sing ndasari lan ngembangake perawatan sing efektif kanggo kahanan sing ngrusak iki.
Vellas B, Andrieu S, Cantet C, Dartigues JF, Gauthier S: Long-term changes in ADAS-cog: what is clinically relevant for disease modifying trials in Alzheimer? J Nutr Health Aging. , 11 (4): 338-41.
Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.
Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.
Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.
Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.
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Informasi sing diwenehake ora kudu digunakake kanggo diagnosa utawa ngobati masalah utawa penyakit kesehatan, lan wong-wong sing golek saran medis pribadi kudu takon karo dokter sing duwe lisensi.
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What causes alzheimer?
Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.
The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.
Some of the factors that may contribute to the development of Alzheimer's disease include:
1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.
2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.
3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.
4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.
5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.
6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.
7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.
8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.
9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.
It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.
Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.
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