Patofisiologi kanker usus buntu nuduhake mekanisme lan proses dhasar sing nyebabake pangembangan lan perkembangan kanker usus buntu.
Kanker kolon, uga dikenal minangka kanker kolorektal, minangka jinis kanker sing diwiwiti ing kolon utawa rektum, sing dadi bagean saka usus gedhe.
Biasane diwiwiti minangka tuwuh sing diarani polip, sing bisa berkembang dadi kanker suwe-suwe.
Patofisiologi kanker usus besar kalebu pirang-pirang faktor, kalebu mutasi genetik, peradangan, lan faktor lingkungan.
Mutasi genetik bisa kedadeyan ing DNA sel usus besar, sing nyebabake tuwuh lan pembagian sel sing ora dikendhaleni.
Mutasi kasebut bisa diwarisake utawa dipikolehi, lan bisa mengaruhi macem-macem gen sing ana gandhengane karo tuwuh, divisi, lan ndandani sel.
Peradangan ing usus buntu, sing bisa disebabake dening kahanan kayata penyakit usus radang, uga bisa nambah risiko kanker usus buntu.
Peradangan kronis bisa nyebabake pelepasan bahan kimia sing ningkatake pertumbuhan lan pembelahan sel, sing bisa nyebabake perkembangan kanker.
Faktor lingkungan, kayata diet, gaya urip, lan paparan bahan kimia tartamtu, uga bisa nyumbang kanggo pangembangan kanker usus besar.
Contone, panganan sing akeh daging abang lan olahan, wis ana gandhengane karo nambah risiko kanker usus besar.
Faktor-faktor liyané, kayata obesitas, ngrokok, lan kurang aktivitas fisik, uga isa nambah risiko.
Sawise kanker usus berkembang, bisa maju liwat pirang-pirang tahap, saka kanker tahap awal sing diwatesi ing usus besar nganti tahap sing luwih maju ing ngendi kanker wis nyebar menyang bagean awak liyane.
Sel-sel kanker bisa nyerang jaringan lan organ sing cedhak, lan uga bisa nyebar liwat sistem limfatik utawa aliran getih menyang situs sing adoh, kayata ati utawa paru-paru.
Perawatan kanggo kanker usus buntu biasane kalebu kombinasi operasi, kemoterapi, lan terapi radiasi, gumantung saka tahap lan lokasi kanker.
Deteksi lan perawatan awal minangka kunci kanggo ningkatake asil, amarga kanker usus besar asring bisa diobati nalika kejiret ing tahap awal.
Skrining rutin, kayata kolonoskopi, bisa mbantu ndeteksi kanker usus buntu ing tahap paling awal, nalika bisa diobati.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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