D acu-tt tfizitulujit n waṭṭan n ukansir n tgezzayt?
Tasnudert n tdawsa n ukunsir n tgezzayt tga azal i tmegrawin d yisenfaren i d-yettawin ɣer usnulfu d ufara n ukunsir n tgezzayt.
Aṭṭan n uksum ameqqran, yettwassen daɣen s yisem n uksum n tgezzayt, d yiwen n ṣṣenf n waṭṭan n uksum i d-ibeddun deg tgezzayt neɣ deg tgezzayt, d iferdisen n tgezzayt tameqqrant.
Yebda-d s umata d yiwen n uferḍas iwumi qqaren apulip, izemren ad yuɣal d akunsir s teɣzi n wakud.
Tasnudert n tdawsa n ukunsir n tgezzayt tettawi-d ɣef waṭas n yimgan, gar-asen ibeddilen ijenṭiyen, afulki d yimgan.
Imuttiyen ijenṭiyen zemren ad d-ilin deg DNA n yiɣsan n uksum, d ayen yettawin ɣer unefli d beṭṭu ur nettwaḥkem ara n yiɣsan.
Imuttiyen-a zemren ad ttwaṛebbin neɣ ad d-ilin, yerna zemren ad d-lhin d yijinaten yemgaraden i yettekkan deg unefli, deg beṭṭu akked useggem n tsilunin.
Asfuǧǧeɣ deg uksum ameqqran, i izemren ad d-yeglu s waṭṭanen am waṭṭan affiẓan n tgeẓẓal, yezmer daɣen ad yesnerni amihi n ukansir n uksum ameqqran.
Asfuǧǧeɣ arurad yezmer ad d-yawi ɣer usuffeɣ n yikamiyulen i yesnernayen amɣi d beṭṭu n tsilunin, ayen yezmer ad d-yawi ɣer usnulfu n kunsir.
Iseɣẓanen n twennaṭ, am učči, amek yettidir yiwen, d tuffɣa ɣer kra n yimɣan, zemren daɣen ad d-rnun ɣer unfafad bu uɛebbuḍ.
Tissit yeččuren d aksum azeggaɣ akked uksum yettwafeṣlen, amedya, tettwassen d akken tettmuddu amihi n ukansir n tgezzayt.
Llan daɣen kra n ssebbat nniḍen, am tuget n lmizan, ddexxan, d lexṣaṣ n waddal, i izemren ad ssemɣaren amihi.
Mi ara d-yebdu kan ukansir n tgezzayt, yezmer ad yeddu deg waṭas n tseddarin, seg ukansir deg tezwara-s i d-yettwaḥebsen kan ɣer tgezzayt ɣer tseddarin yugaren aya anda kansir yemgarad ɣer tamiwin-nniḍen n tfekka.
Izirigen n ukunsir zemren ad kecmen izerfan d yiẓuran iqerben, yerna zemren daɣen ad ttwazerɛen s unagraw n tneffaḥt neɣ s azamul n yidammen ɣer yimukan ibeɛden, am tasa neɣ afud.
Asafar n ukansir n teɣmest deg umata d ahil n temhelt, n tesnujjya, n takimit d tesnujjya s wazal, ɣef leḥsab n uswir d umkan n ukansir.
Tujjya d usemmiḍ zik d tasarut i usnerni n yigmaḍ, acku akunsir n tgezzayt yezmer ad yeḥlu s waṭas ma yettwaṭṭef deg tezwara-s.
Asekyed n tezdeg, am tmuɣli n teɣmert, yezmer ad iεiwen ad d-yaf akunsir n teɣmert deg tezwara-s, mi ara yili yeshel ad yettwaḥlu.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
['Anfafad: amejjay']
['Asmel-a web yettunefk-d kan i yiswiyen n uselmed d usissen, ur d-yettak ara iwellihen imejjayen neɣ isefka udmawanen.']
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['Anekcum: azref n uḍfar']
['Asaḍuf n umeskar n yizerfan n wemdan n alfin (Digital Millennium Copyright Act) n 1998, 17 U.S.C. § 512 (DMCA) yettak-d ttawil i yimeskaren n yizerfan n wemdan i yumnen belli ayen i d-yettbanen deg Internet yettḍurru izerfan-nsen ddaw usaḍuf n umeskar n yizerfan n wemdan n Marikan. ']
['Ma tumneḍ s wul yelhan belli kra n taɣult neɣ taɣawsa yettwafken deg unermes-nneɣ neɣ deg yiqeddacen-nneɣ tegzem azref-ik n uḥraz, tzemreḍ (neɣ amsedday-ik) ad aɣ-d-tazneḍ izen akken ad nessuter asuffeɣ n taɣult neɣ n taɣawsa-nni, neɣ ad nessader tuqqna ɣer-s. ']
['Isental yessefk ad ttwazen s tira s yimayl (ẓer asebter "Contact" i tansa n yimayl).']
['DMCA teḥwaǧ isalli-inek n tukksa n yizerfan yettwanekṛen ad d-yeglu s yisallen-a: (1) asegzi n umahil yettwaḥerzen s yizerfan yettwanekṛen i d-yettwanekren; (2) asegzi n uḍris yettwanekren d yisallen ara aɣ-yeǧǧen ad d-naf uḍris-nni; (3) isallen n usiwel inek, ladɣa tansa-inek, uṭṭun n tilifun d tansa imayl; (4) awal sɣur-k d akken tumneḍ s wayen yelhan belli aḍris-nni s wamek i d-tettcetkiḍ ur yettwasemres ara sɣur bab n yizerfan, neɣ amesten-is, neɣ s useqdec n kra n usaḍuf; ']
['(5) yiwet n tseddi sɣur-k, yettwatten s uḥasef n lekdeb, d akken isallen yellan deg uzenzi d iṣeḥḥan u tesεiḍ azref ad tesseḍruḍ izerfan umeskar i d-yeqqaren ttwarẓen; ']
['akked (6) azmul n tfekka neɣ n tuqqna tagensit n bab n yizerfan neɣ n umdan yettwafernen ad yexdem s yisem n bab n yizerfan. ']
['Ma ur d-terriḍ ara isallen-agi akk, yezmer ad d-yeglu s uεeṭṭel deg usefrek n ucetki-inek.']
['Assaɣ']
['Ttxil-k azen-aɣ-d imayl ma tesεiḍ asteqsi / asumer.']
What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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