What causes Colon cancer?

['Ĩthukĩĩsye ũvoo ũũ']

Nĩ kyaũ kĩtumaa mũndũ ethĩwa na kanza ya kĩthũi?

Mũndũ nũtonya kũwaa kanza ya ĩmutha kwa nzĩa yĩ kĩvathũkany'o na ũndũ andũ aingĩ mekaa.

Ũwau wa colon cancer ndwĩsa kũwetwa nesa, ĩndĩ ve maũndũ amwe matonya kũtuma ũwau ũsu wĩthĩwa wĩ mũthũku.

Maũndũ asu nĩ ta:

1. Ũkũũ: Mũndũ akũa ethĩawa na ũwau wa kanza ya kĩthũi na mũno mũno ethĩwa e na myaka mbee wa 50.

2. Andũ amwe ma mũsyĩ maĩ na ũwau ũsu: Ethĩwa mũndũ e na ũwau wa kanza ya kĩthũi kana wa mavũi, nũtonya kwĩthĩwa na ũwau ũsu.

3. Maũndũ amwe mũndũ ũsyaawa namo: Ve maũndũ amwe mũndũ ũsyaawa namo ta ũwau wĩtawa familial adenomatous polyposis (FAP) na ũwau ũngĩ wĩtawa hereditary non-polyposis colorectal cancer (HNPCC).

4. Maũndũ ala mũndũ wĩkaa: Kũya nyama mbingĩ na kũya mũno, kũya mũno, kũnyw'a sikala, na kũnyw'a ũkĩ mũno no kũtume mũndũ ethĩwa na ũwau wa kanza ya mavũi.

5. Ũwau wa kũvĩvw'a kwa mavĩndĩ: Mũndũ eethĩwa na ũwau wa kũvĩvw'a kwa mavĩndĩ kwa ĩvinda ĩasa, ta ũwau wĩtawa ulcerative colitis na Crohn's disease, nũtonya kũkwata kanza ya mavĩndĩ.

6. Ũwau wa mũthemba wa 2 wa sukalĩ: Andũ ala makwatĩtwe nĩ ũwau ũsu methĩawa matonya kũkwatwa nĩ kanza ya kĩthũi.

7. Kũiitwa na nzeve: Kũiitwa na nzeve ĩla ĩkwataa andũ ala me na kanza ya ĩvu nĩkũtonya kũtuma mũndũ ethĩwa na ũwau wa kanza ya kĩthũi.

8. Ũko: Andũ ma Africa ala mekalaa Amelika methĩawa matonya kũkwatwa nĩ kanza ya kĩthũi mũno kwĩ andũ ma mbaĩ ingĩ.

Nĩ ũndũ wa vata kũmanya kana mũndũ eethĩwa na ũmwe kana o maũndũ maingĩ matonya kũtuma akwatwa nĩ kanza ĩsu, ti lasima akethĩwa nayo.

Kwĩthĩwa na mũvango wa kwĩyĩosya mavinda kwa mavinda na kũmanya ĩla mũndũ wĩ na kanza tene no kũtume ũsiĩĩwa kana ũimanya tene ĩla yĩ laisi kũiitwa.

['Maũndũ ma kwongeleela']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

McWhirter JE, Todd LE, Hoffman-Goetz L: Beliefs about causes of colon cancer by English-as-a-Second-Language Chinese immigrant women to Canada. J Cancer Educ. 2011, 26 (4): 734-9.

Gamble JF: Asbestos and colon cancer: a weight-of-the-evidence review. Environ Health Perspect. 1994, 102 (12): 1038-50.

Ashish S, Raj M: Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden. Cureus. 2022, 14 (3): e22894.

Xu W, Zhang Y, Chen L, Qiu F, Zhang B, Wu L, Peng Z, Tang H: Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget. 2017, 8 (42): 71954-71964.

Wang J, Wu HF, Shen W, Xu DY, Ruan TY, Tao GQ, Lu PH: SRPK2 promotes the growth and migration of the colon cancer cells. Gene. 2016, 586 (1): 41-7.

Taketo MM, Edelmann W: Mouse models of colon cancer. Gastroenterology. 2009, 136 (3): 780-98.

Slattery ML, Kerber RA: The impact of family history of colon cancer on survival after diagnosis with colon cancer. Int J Epidemiol. 1995, 24 (5): 888-96.

['Ũtao:']

["Kĩsese kĩĩ kĩseũvĩtw'e kwondũ wa kũmanyĩsya na kũtetheesya andũ, ĩndĩ ti kũnengane motao ma ũiiti kana ũtethyo ũngĩ."]

['Ũvoo ũla wĩ vo ndwaĩle kũtũmĩwa kũĩkĩĩthya kana mũndũ e na ũwau mũna, na ala mekwenda ũtao wa ũiiti maĩle kũneena na ndakĩtalĩ.']

["Kwa ngelekany'o, ĩla mũndũ wakũlya ĩkũlyo yĩ na namba, no amanye kana mũndũ ũsu e na ũwau mũna."]

['Kĩla ĩvinda neena na ndakĩtalĩ waku kana mũndũ ũngĩ ũsomeete maũndũ ma ũiiti. Ndũkaatate kũlea kana kũkua ĩvinda ũimũkũlya ũtao aĩ nũndũ wa maũndũ amwe wasoma Kĩsesenĩ kĩĩ. Ethĩwa wĩona ta wĩ na thĩna wa mĩtũkĩ, neena na namba ya 911 kana ũthi sivitalĩ ya mĩtũkĩ ĩla yĩ vakuvĩ.']

['Ũtao:']

['The Digital Millennium Copyright Act of 1998, 17 U.S.C. § 512 (the DMCA) nĩyaĩtye kana ala me na ũthasyo wa kumĩthya syĩndũ ila syĩ Indanetinĩ nĩmaĩle kũtata ũndũ matonya nĩ kana maĩkĩĩthye kana syĩndũ ila mekumĩthya nĩsyavĩnga mĩao ya nthĩ ya Amelika.']

['Ethĩwa wĩ na mũĩkĩĩo kana ũvoo ũla wĩ kĩsesenĩ kitũ kana nthĩnĩ wa syĩndũ ila tumasya nũvĩtĩsye mĩao yaku, no ũtũtũmĩe valũa ũũtwĩĩte kana no ũtũsiĩĩe tũikamĩsome.']

['No ũtũmĩe valũa ũũ (sisya vala vaandĩkĩtwe "Ndũkatũmĩe valũa ũũ") ũnyaĩĩkya ũvoo.']

["Mĩao ya DMCA yaĩtye kana no nginya ũvoo ũla ũũtũmĩa kũtũtavya kana ve kĩndũ kĩna kĩnavĩnga mĩao ya kumĩthya syĩndũ wĩthĩwe na ũvoo ũũ: (1) ũvoo ĩũlũ wa syĩndũ ila iwetetwe kana nĩsyo ivĩngĩĩsiwe nĩ mĩao ĩsu; (2) ũvoo ĩũlũ wa syĩndũ ila iwetetwe kana nĩsyo ivĩngĩĩsiwe nĩ mĩao ĩsu na ũvoo ũtonya kũtũtetheesya kũmanya vala syĩndũ isu syĩ; (3) ũndũ ũtonya kũtũtavya ũndũ ũtonya kũtũtavya ũndũ ũtonya kũũkũlya, ta vala wĩkalaa, namba yaku ya simũ, na valũa waku wa simũ; (4) ũĩkĩĩthyo ũkwonany'a kana wĩ na mũĩkĩĩo kana syĩndũ ila iwetetwe vau iyĩtĩkĩlĩtw'e nĩ ũla wĩ na ũthasyo wa kũseũvya syĩndũ, kana nĩ mũũngamĩi wasyo, kana nĩ mĩao ĩngĩ."]

["(5) ũĩkĩĩthyo kuma kwaku, ũla ũandĩkĩte ũikĩa ũkũsĩ ũte wa w'o, kana ũvoo ũla wĩ nthĩnĩ wa livoti nĩ wa w'o na kana wĩ na ũkũmũ wa kũũngamĩa maũndũ ala mawetwa nĩ ũla ũkũũmĩw'a;"]

['Na (6) saii ya mwene syĩndũ kana mũndũ ũla ũnengetwe ũkũmũ wa kwĩka maũndũ kwondũ wake.']

['Ethĩwa ndũwetete maũndũ asu onthe, nũtonya kũema kwĩtetea.']

['Ũndũ ũtonya kũneena namo']

['Tũmĩa email ũtũkũlye kana ũnenge ũtao.']

What causes colon cancer?

Colon cancer, also known as colorectal cancer, is caused by the uncontrolled growth of abnormal cells in the colon or rectum.

The exact cause of colon cancer is not known, but several factors can increase the risk of developing the disease.

These include:

1. Age: The risk of colon cancer increases with age, with most cases occurring in people over the age of 50.

2. Family history: A personal or family history of colon cancer or polyps increases the risk of developing the disease.

3. Inherited syndromes: Certain inherited genetic syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), can increase the risk of colon cancer.

4. Lifestyle factors: A diet high in red and processed meats, obesity, smoking, and excessive alcohol consumption can increase the risk of colon cancer.

5. Inflammatory bowel disease: Long-term inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, can increase the risk of colon cancer.

6. Type 2 diabetes: People with type 2 diabetes have an increased risk of developing colon cancer.

7. Radiation therapy: Radiation therapy for other cancers in the abdomen can increase the risk of colon cancer.

8. Race: African Americans have a higher risk of developing colon cancer than other races.

It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop colon cancer, and some people who develop colon cancer may not have any known risk factors.

Regular screening and early detection can help prevent colon cancer or detect it at an early stage when it is most treatable.

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