Fisiopatolojia di kankru di sélu ten aver ku mekanismus y prusésus subjacenti ki ta leba a dizenvolvimentu y prugrésu di kankru di sélu.
Kanseru di kólon, tanbê konxedu pa kankru kolorektal, é un tipu di kankru ki ta kumesa na kólon ô retal, ki é párti di intestin grós.
El ta kumesa sima un pólipu ki pode bira un kankru.
Fisiopatolojia di kankru di kólon ten txeu fatoris sima mutagens jenétiku, inflamason y fatoris anbiental.
Alvês, ta kontise mutonas na DNA di sélulas di kólon ki ta poi sélulas ta kria sen kontrola.
Kes mudansa li pode kontise na korpu ô na manera ki algen ta fika.
Inflamason na cólon, ki pode ser kauza di kondison sima duensa inflamatóriu intestinal, tanbê podi aumenta risku di kankru di cólon.
Inflamason pode poi sélulas ta kria txeu i ta dividi, asi el ta da kansera.
Fatoris anbiental sima dieta, stilu di vida, y isposison a alguns kimikas podi kontribui pa dizenvolvimentu di kankru di colon.
Pur izénplu, txeu tipu di karni i karni finu ki ta podu na fabrika, ta poi algen ta ten más risku di ten kankru di séklu.
Otus kuza ki pode poi algen ta fika duenti é ségu, fuma i ka faze txeu atividadi fíziku.
Óras ki kanser di sélu di dôs pésa kumesa, el pode pasa pa txeu stádiu, désdi kankru na stádiu inisial ki ta fika sô na sélu di dôs pésa ti más avansadu undi kankru dja spadja pa otus párti di korpu.
Kel kankru pode invadi txon i órgons pértu i el pode spadja pa korpu ô sangi ti korpu lonji sima fígadu ô pulmon.
Tratamentu pa kankru di sélu ta inklui un konbinason di operason, kimioterapia, y radioterapia, dipendi di stájiu y lokalizason di kankru.
Deteson y tratamentu prévi é fundamental pa midjora rezultadus, pamodi kansera di kólon é kurável óki detetadu na stádiu prévi.
Un izami di sélu, sima kolonoskopiu, pode djuda diskubri kankru di sélu na sédu, óras ki é más fásil di kura.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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