What is pathophysiology of Lung cancer?

['Thikĩrĩria karatathi gaka']

Pathophysiology ya cancer ya mahũri ĩkoragwo ĩhaana atĩa?

Pathophysiology ya cancer ya mahũri ĩkoragwo ĩĩ mogarũrũku harĩ mĩtaratara na njĩra cia ndũire iria cionekaga harĩ gũkũra na gũthũka kwa cancer ya mahũri.

Mũrimũ wa kansa ya mahũri nĩ mũrimũ mũũru mũno ũrĩa uumanaga na gũkũra na gũciarana kwa tũhengereta tũtarĩ na kĩhaarĩro thĩinĩ wa mahũri.

Tũhengereta tũu no tũthondeke mĩrimũ ya kansa na tũthereme nginya ciĩga-inĩ ingĩ cia mwĩrĩ, na ũndũ ũcio ũrehe mathĩna maingĩ.

Mũrimũ wa kansa ya mahũri ũrehaga maũndũ matiganĩte, ta mũrimũ wa gũcenjia maũthĩ, maũndũ ma rĩera, na mĩtũũrĩre.

Tũindo twa DNA no tũgarũrũke thĩinĩ wa tũhengereta twa mahũri, tũgatũma tũhengereta tũingĩhe na tũgayũkane.

Mogarũrũku macio no maumanire na mũciari kana mũndũ agĩe namo, na no mathererio nĩ indo iria irehaga kansa, ta ndogo ya thigara, radon, asbestos, na rĩera rĩũru.

Mũrimũ wa kanza ya mahũri no ũgayanio na mĩthemba ĩĩrĩ: kanza ya mahũri ya tũhengereta tũnini (SCLC) na kanza ya mahũri ĩtarĩ tũhengereta tũnini (NSCLC).

Pathophysiology ya mĩthemba ĩno ya cancer ya mahũri no ĩkorũo ĩrĩ ngũrani, tondũ ikoragwo na mogarũrũku ngũrani ma kĩĩmerera na ikoragwo na ũhoti ngũrani wa kũrigitwo.

Mũrimũ wa kansa ya mahũri ũkoragwo na ngwatanĩro gatagatĩ ka tũhengereta tũrĩa tũrutaga kansa na tũrĩa tũrigicĩirie, hamwe na mũrwaru kũrũa na mũrimũ ũcio.

Tũhengereta twa kansa nĩ tũhotaga gwĩthema gũtharario nĩ mwĩrĩ, na ũndũ ũcio ũgatũma tũhote gũkũra na gũtheerema tũtekũgirĩrĩrio.

Makĩria ma ũguo, handũ harĩa kahengereta gakoragwo na tũcunjĩ tũnini mũno kahota gũkũria na gũtheremia kahengereta kau na njĩra ya gũgatũma gakorũo na tũcunjĩ tũnini mũno tũrĩa tũnyitaga mwĩrĩ.

Pathophysiology ya cancer ya mahũri nĩ mũtaratara mũrikĩru na wa hinya, na athuthuria nĩ marathiĩ na mbere kũgeria gũtaũkĩrwo wega nĩ njĩra iria ihũthĩkaga gũthondeka njĩra cia ũrigitani iria ciagĩrĩire na kwagagĩria moimĩrĩro ma arwaru.

['Ũhoro wa kwambĩrĩria']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Li Z, Qian Y, Li W, Liu L, Yu L, Liu X, Wu G, Wang Y, Luo W, Fang F, Liu Y, Song F, Cai Z, Chen W, Huang W: Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020, 23 (8): 101411.

Nurwidya F, Syahruddin E, Yunus F: Pain management in lung cancer. Adv Respir Med. 2016, 84 (6): 331-336.

Khan KA, Kennedy MP, Moore E, Crush L, Prendeville S, Maher MM, Burke L, Henry MT: Radiological characteristics, histological features and clinical outcomes of lung cancer patients with coexistent idiopathic pulmonary fibrosis. Lung. 2015, 193 (1): 71-7.

Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A: Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. Int J Mol Sci. 2022, 23 (21): .

Lee D, Kim Y, Chung C: Scientific Validation and Clinical Application of Lung Cancer Organoids. Cells. 2021, 10 (11): .

Mucchietto V, Crespi A, Fasoli F, Clementi F, Gotti C: Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des. 2016, 22 (14): 2160-9.

['Ũkaana: thibitarĩ']

['Website ĩno ĩkoragwo ĩrĩ ya kũrutana na kũheana ũhoro tu na ti ya kũheana ũtaaro wa ũrigitani kana ũtungata wa kĩĩmwĩrĩ.']

['Ũhoro ũrĩa ũrĩ thĩinĩ wa broshua ĩyo ndwagĩrĩirũo kũhũthĩrũo gũthima kana kũrigita mũrimũ mũna, na arĩa marenda ũtaaro wa ũrigitani magĩrĩirũo gũcaria ũteithio wa ndagĩtarĩ.']

['No wone atĩ netiwaki ya neuron ĩrĩa ĩheanaga macokio ma ciũria icio, ndĩkoragwo na ũkinyanĩru mũno ũhoro-inĩ wĩgiĩ namba. Kwa ngerekano, mũigana wa andũ arĩa magwatĩtio mũrimũ mũna.']

['Hingo ciothe caria ũtaaro wa ndagĩtarĩ kana mũndũ ũngĩ wagĩrĩire ũgima-inĩ waku wa mwĩrĩ igũrũ rĩgiĩ mũrimũ. Ndũkaanahũthie ũtaaro wa ndagĩtarĩ kana ũcererũo kũũcaria nĩ ũndũ wa ũndũ ũthomete thĩinĩ wa website ĩno. Ũngĩkorũo ũrona ta wacemania na ũndũ mũhiũ, hũra thimũ 911 kana ũthiĩ thibitarĩ ya hakuhĩ na harĩa ũrĩ. Gũtirĩ ũrata wa ndagĩtarĩ na mũrwaru wonekaga nĩ ũndũ wa website ĩno kana kũhũthĩrũo kwayo. BioMedLib kana aruti ayo a wĩra, kana mũndũ ũngĩ wothe ũrutĩte wĩra thĩinĩ wa website ĩno, ndarĩ na ũira, wa ĩmwe kwa ĩmwe kana wa ĩmwe kwa ĩmwe, wĩgiĩ ũhoro ũrĩa ũheanĩtwo ho kana ũrĩa ũhũthĩrĩtwo.']

['Ũregani: wĩyathi wa kwandĩka']

['Watho wa Digital Millennium Copyright Act wa 1998, 17 U.S.C. § 512 (the DMCA) ũheanaga ũhoti wa ene a ihoto cia wandĩki arĩa metĩkĩtie atĩ ũhoro ũrĩa ũroneka intanetiinĩ nĩ ũtharĩtie ihooto ciao kũringana na watho wa U.S. wa ihoto cia wandĩki.']

['Ũngĩkorũo na wĩtĩkio atĩ ũhoro kana kĩndũ kĩna gĩtahingũrĩtwo ũhoro-inĩ wĩgiĩ website kana ũtungata witũ nĩ gĩgũthũkia ihooto ciaku, wee (kana mũndũ ũrĩa ũgũgũthondekera) no ũtũtũmĩre notithi ũkĩũria ũhoro kana kĩndũ kĩu kĩeherio, kana ũrigĩrĩrio ndũgacihũthĩre.']

["Marũa macio magĩrĩire gũtũmwo na njĩra ya kwandĩkwo na e-mail (rora ũhoro wa andirethi gĩcunjĩinĩ kĩa 'Maũndũ ma kwaranĩria')."]

['DMCA ĩbataraga atĩ notithi yaku ya kuuna ihooto cia wandĩki ĩkorwo na ũhoro ũyũ: (1) ũtaarĩria wa wĩra ũrĩa ũrĩ na ihooto cia wandĩki ũrĩa ũrarumwo; (2) ũtaarĩria wa ũhoro ũrĩa ũrarumwo na ũhoro mũiganu wa gũtũhotithia kũmenya kũrĩa ũhoro ũcio ũrĩ; (3) ũhoro waku wa kwaranĩria, hamwe na andirethi, namba ya thimũ na andirethi ya e-mail; (4) ndũmĩrĩri yaku atĩ wĩ na wĩtĩkio mwega atĩ ũhoro ũcio ũramenererio ndũrĩ na rũtha rwa mwene wa watho, kana mũrũgamĩrĩri, kana rwa watho o wothe; ']

['(5) nĩ mwandĩkanĩire, na nĩ mũkũheo mũkaana wa kũheenania, atĩ ũhoro ũrĩa ũrĩ kĩmenyithiainĩ kĩu nĩ wa ma na atĩ mũrĩ na ũhoti wa kũhingia ihooto iria mũreganĩte nacio;']

['na (6) kĩrore kĩa mwene kĩhoto kana kĩa mũndũ wĩtĩkĩritio gwĩtongoria handũ ha mwene kĩhoto.']

['Kwaga kwandĩka ũhoro ũcio wothe no gũtũme gũtangĩka gwaku kũhĩtũke.']

['Ũhoro wa Kwaranĩria']

['Tũma ndũmĩrĩri ya kũbucia kũgerera thimũ kana thimũ ya mohoro.']

What is pathophysiology of lung cancer?

The pathophysiology of lung cancer refers to the changes in the normal physiological processes and mechanisms that occur in the development and progression of lung cancer.

Lung cancer is a complex disease that arises from the uncontrolled growth and division of abnormal cells in the lungs.

These cells can form tumors and spread to other parts of the body, leading to various symptoms and complications.

The pathophysiology of lung cancer involves several factors, including genetic mutations, environmental factors, and lifestyle choices.

Genetic mutations can occur in the DNA of lung cells, leading to uncontrolled cell growth and division.

These mutations can be inherited or acquired, and they can be caused by exposure to carcinogens, such as tobacco smoke, radon, asbestos, and air pollution.

Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is further divided into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.

The pathophysiology of these types of lung cancer can differ, as they have different genetic mutations and respond differently to treatment.

The pathophysiology of lung cancer also involves the interaction between cancer cells and the surrounding tissue, including the immune system.

Cancer cells can evade the immune system, allowing them to grow and spread unchecked.

Additionally, the tumor microenvironment can promote tumor growth and metastasis by providing a supportive environment for cancer cells.

The pathophysiology of lung cancer is a complex and dynamic process, and researchers are continuously working to better understand the underlying mechanisms to develop more effective treatments and improve patient outcomes.

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