How is Alzheimer diagnosed?

['Ívua o mbandu íii']

Kiebhi kia tena kuijiia se o muthu uala ni uhaxi ua ku jimba?

O uhaxi ua Alzheimer a u tungula mu maukexilu avulu, kala o ku tala kiambote o uhaxi, ku tonginina o uongo, ni ima ia mukuá dingi.

1. Ku mu tala ku dotolo: O dotolo ua-nda mu tala, ni kuijiia o uhaxi uê, phala kuijiia se ua mu jimba ima, mba ua mu kata.

2. Ku tonginina o kilunji ni uongo: O ji polova jiji ji tonginina o kilunji, o dimi, ni ima ia mukuá dingi phala kuijiia se o muthu uala ni kilunji kia neme mba kana, ni kuijiia ué se o muthu uala ni kilunji kia neme mukonda dia ku kuka mba kana.

3. Ku tala o uongo: O ji makina ji bhanga o ji makina ja ku tala o uongo (MRI) mba komputadolo (CT) ji tena ku kuatekesa kuijiia o uongo se uala ni uhaxi ua Alzheimer.

O ji makina jiji, a ji xana PET, ji tena ué ku kuatekesa kuijiia se o muthu uala ni uhaxi ua Alzheimer.

4. Ku tokuesa o manhinga: O jingijiie a tokuesa kuila, o ku tala o manhinga, ku tena ku kuatekesa kuijiia se o muthu uala ni uhaxi ua ku jimba, mba kana.

5. O ukexilu ua ku dituna o uhaxi: Mukonda dia ku kamba ukexilu ua ku tungula o uhaxi ua Alzheimer, phala ku tena ku sanga o uhaxi iú, ku bhinga kuijiia se o uhaxi iú ua lungu ni kima kiéngi.

O ji dotolo amba kuila, o uhaxi iú, a tena ku u sanga ngó se o muthu ua fuá u tala kiambote o uongo.

Maji o ukexilu ua ku saka, u tena ku kuatekesa o muthu ua kate, kioso o muthu kiaia ni ku kula.

O kuijiia se o uhaxi ua muthu ua-nda dibandekesa mba kana, kima kiambote phala o muthu ku tena ku mateka ku di saka ni ku di sokejeka phala ku dibhana ni uhaxi iú ku hádia.

['Izuelu ia mukuá']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Liu SS, Zhu SQ: [Correlation between Alzheimer disease and cataract]. Zhonghua Yan Ke Za Zhi. 2017, 53 (4): 314-316.

Gauthier S: Practical guidelines for the antemortem diagnosis of senile dementia of the Alzheimer type. Prog Neuropsychopharmacol Biol Psychiatry. 1985, 9 (5-6): 491-5.

Rubin R: New Test to Help Diagnose Alzheimer Disease. JAMA. 2022, 327 (23): 2281.

[Blood Based Biomarker for Optimization of Early and Differential Diagnosis of Alzheimer's Dementia]. Fortschr Neurol Psychiatr. 2022, 90 (7-08): 326-335.

Kapp MB: Physicians' legal duties regarding the use of genetic tests to predict and diagnose Alzheimer disease. J Leg Med. 2000, 21 (4): 445-75.

Britschgi M, Wyss-Coray T: Blood protein signature for the early diagnosis of Alzheimer disease. Arch Neurol. 2009, 66 (2): 161-5.

Volicer L, Berman SA, Cipolloni PB, Mandell A: Persistent vegetative state in Alzheimer disease. Does it exist? Arch Neurol. 1997, 54 (11): 1382-4.

Imabayashi E, Saitoh Y, Tsukamoto T, Sakata M, Takano H: Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18 F-THK5351. Clin Nucl Med. 2022, 47 (12): 1066-1068.

Martínez A, Lahiri DK, Giacobini E, Greig NH: Advances in Alzheimer therapy: understanding pharmacological approaches to the disease. Curr Alzheimer Res. 2009, 6 (2): 83-5.

['Kitendelesu:']

['O kijimbuete kiki, phala ku longa ngó, ki kiene mu bhana milongi ia lungu ni sauidi.']

['O milongi íii, ka tokala ku i tumbula phala ku saka uhaxi, mba ku saka mauhaxi a mukuá.']

['Mu kifika, o ji komputadolo jene mu kuatekesa o athu kuijiia o ima ia lungu ni uhaxi, ki ji tena ku jimbulula kiambote o maka.']

['Sota kikuatekesu kia dotolo iê mba muthu ua mukuá uala ni uhete ua ku saka mauhaxi. Kana ku jimba o itendelesu ia dotolo mukonda dia milongi i ua tange mu kijimbuete kiki. Se ua mesena kikuatekesu, xinda ku muxinda ua 112, mba ndé mu inzo ia ku saka ia zukama.']

['Iala ni Kikutu ni Jinguvulu ja Jixi Jengi']

['O Digital Millennium Copyright Act of 1998, 17 U.S.C. § 512 (o DMCA) i bhana ku athu ala ni ufolo ua ku soneka, o ima ia mona mu Internete, i bhukumukina o ufolo uâ ua ku soneka. ']

['Se eie u xikina ni kidi kioso kuila o milongi mba milongi i ua mu tanga mu kijimbuete kietu kia internete, mba mu ima ia mukuá, ia mu bhukumukina o itumu iê, eie (mba o muthu u ua mu tumina) u tena ku tu tumikisa mukanda ni ku tu bhinga phala ku katula o milongi mba milongi i ua mu tanga mba ku fidisa o muthu ku i tanga.']

['O ngolokela a tokala ku i tumikisa mu mukanda ni mu kijimbuete kia i-me-le (Tala o mbandu "Utuameni ua Ijimbuete") ].']

['O DMCA i bhinga kuila o njimbu iê ia lungu ni ku bhukumukina o itumu ia ku tokala, i kala ni milongi íii: (1) kijimbuluilu kia kikalakalu kia tokala ku kitumu kia ku tokala; (2) kijimbuluilu kia milongi ia ku tokala ni milongi i tua tokala ku sanga; (3) o ijimbuete iê, ni ijimbuete ia mutelembe uê; (4) ni izuelu i ua zuela kuila eie u xikina ni kidi kioso kuila o milongi ia ku tokala, ki i tokala ku ngana ia tokala, mba ku mukunji uê, mba ku kitumu kioso-kioso; ']

['(5) O kijimbuete kiê, ni kijimbuete kia ku tangela kuila o milongi iala mu kijimbuete kiki ia kidi, ni kuila eie uala ni kutena kua ku langa o ima ia ku tokala;']

['O kijimbuete kiki, ki tena ku kala ni kidimbu kiê, mba kijimbuete kia muthu ua mu tumina o ku ki jikula.']

['Se ku soneka o ima ioso íii, o ku tokuesa o maka mê kua-nda laleka.']

['Kuzuela ni Muthu']

['Tua ku dióndo, tu tumikise njimbu ni ibhuidisu mba jindunge.']

How is alzheimer diagnosed?

Alzheimer's disease is diagnosed through a combination of methods, including a thorough medical evaluation, cognitive and neuropsychological tests, brain imaging, and the process of elimination of other possible causes.

1. Medical evaluation: A doctor will perform a physical examination and take a detailed medical history to rule out other possible causes of memory loss or cognitive decline, such as thyroid problems, vitamin deficiencies, or brain tumors.

2. Cognitive and neuropsychological tests: These tests assess memory, language, problem-solving, and other cognitive functions to determine the extent of cognitive impairment and to differentiate between normal age-related memory loss and dementia.

3. Brain imaging: Magnetic resonance imaging (MRI) or computed tomography (CT) scans can help identify structural changes in the brain that may indicate Alzheimer's disease.

Positron emission tomography (PET) scans can also be used to measure the levels of certain proteins associated with Alzheimer's disease.

4. Blood tests: Recent research has shown that certain blood tests can help diagnose Alzheimer's disease by measuring the levels of specific proteins or biomarkers associated with the disease.

5. Process of elimination: Since there is no single definitive test for Alzheimer's disease, diagnosis often involves ruling out other possible causes of dementia-like symptoms.

It is important to note that a definitive diagnosis of Alzheimer's disease can only be made after death through an examination of brain tissue.

However, current diagnostic methods can provide a high level of certainty for a clinical diagnosis while the person is still alive.

Early diagnosis is important for starting treatment and planning for the future.

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