What causes Alzheimer?

['Ívua o mbandu íii']

Ihi i bhangesa o muthu ku kala ni uhaxi ua ku jimba?

O uhaxi ua uongo, u bhangesa o muthu ku jimba o ima ni ku kala ni ukexilu ua iibha.

O uhaxi iú, ka u xikina luua ni kidi kioso, maji ene mu u xikina kuila ua tundu ku muiji, ku athu ala mu kididi kieniókio, ni ukexilu ua athu.

O ima i tena ku bhangesa o muthu ku kala ni uhaxi ua Alzheimer, íii:

1. O uhaxi u tunda ku muiji: Saí ji célula, jene mu bhangesa o muthu ku kala ni uhaxi ua ku jimba, bhenge-bhenge o célula i kuatekesa o muthu ku kala ni uongo ua uabha.

2. O kitala: O uhaxi ua uongo u dimendala dingi kioso o muthu kiaia ni ku kuka.

3. O muiji u tena ku kala ni uhaxi iú: Se o muiji u kala ni uhaxi iú, o muthu u tena ku kala ni uhaxi iú.

4. O mutué u jituina: Se o muthu ua di kuama kiá kiavulu ku mutué, nange u jituina, o uhaxi ua ku jimba o ima, u tena ku di bandekesa dingi.

5. O uhaxi ua muxima: O uhaxi ua ku kala ni manhinga avulu mu manhinga, ni ku kala ni sukidi iavulu mu manhinga, ni uhaxi ua ku kala ni sukidi iavulu mu manhinga, u tena ku bhangesa o muthu ku kala ni uhaxi ua ku jimba o ima ia bhiti kiá.

6. O ukexilu ua muenhu: O ku kamba o ku bhanga ima iavulu, o ku kamba kudia kiambote, ni ku kamba ku bhanga ima i suínisa o uongo, ku tena ku bhangesa o muthu ku kala ni uhaxi ua ku jimba o ima ia bhiti.

7. O uhaxi ua uongo: O uongo u tena ku kala ni uhaxi ua uongo.

8. O uhaxi ua uongo: O ku kamba ku kala ni ukexilu uambote ua ku bhanga o ima, ku bhangesa o mukutu ku kamba ku bhanga kiambote o ima.

9.Jindolo ja kisongo ku pumbulu ni ku nhunga ku uongo: O ku di bhongolola kua ndolo ku pumbulu ni ku nhunga ku pumbulu ku uongo, ku bhangesa o muthu ku kala ni uhaxi ua ku jimba, maji o athu kejiia kiambote se o uhaxi iú u tunda kuebhi.

Kima kiambote kuijiia kuila o uhaxi ua Alzheimer u bheka jiphaxi javulu.

O jingijiie a mu tokuesa kiavulu o maka enhá phala kuijiia se kiebhi ki kala o uhaxi iú ni ku sanga milongo phala ku u saka.

['Izuelu ia mukuá']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Vellas B, Andrieu S, Cantet C, Dartigues JF, Gauthier S: Long-term changes in ADAS-cog: what is clinically relevant for disease modifying trials in Alzheimer? J Nutr Health Aging. , 11 (4): 338-41.

Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.

Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.

Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.

Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.

['Kitendelesu:']

['O kijimbuete kiki, phala ku longa ngó, ki kiene mu bhana milongi ia lungu ni sauidi.']

['O milongi íii, ka tokala ku i tumbula phala ku saka uhaxi, mba ku saka mauhaxi a mukuá.']

['Mu kifika, o ji komputadolo jene mu kuatekesa o athu kuijiia o ima ia lungu ni uhaxi, ki ji tena ku jimbulula kiambote o maka.']

['Sota kikuatekesu kia dotolo iê mba muthu ua mukuá uala ni uhete ua ku saka mauhaxi. Kana ku jimba o itendelesu ia dotolo mukonda dia milongi i ua tange mu kijimbuete kiki. Se ua mesena kikuatekesu, xinda ku muxinda ua 112, mba ndé mu inzo ia ku saka ia zukama.']

['Iala ni Kikutu ni Jinguvulu ja Jixi Jengi']

['O Digital Millennium Copyright Act of 1998, 17 U.S.C. § 512 (o DMCA) i bhana ku athu ala ni ufolo ua ku soneka, o ima ia mona mu Internete, i bhukumukina o ufolo uâ ua ku soneka. ']

['Se eie u xikina ni kidi kioso kuila o milongi mba milongi i ua mu tanga mu kijimbuete kietu kia internete, mba mu ima ia mukuá, ia mu bhukumukina o itumu iê, eie (mba o muthu u ua mu tumina) u tena ku tu tumikisa mukanda ni ku tu bhinga phala ku katula o milongi mba milongi i ua mu tanga mba ku fidisa o muthu ku i tanga.']

['O ngolokela a tokala ku i tumikisa mu mukanda ni mu kijimbuete kia i-me-le (Tala o mbandu "Utuameni ua Ijimbuete") ].']

['O DMCA i bhinga kuila o njimbu iê ia lungu ni ku bhukumukina o itumu ia ku tokala, i kala ni milongi íii: (1) kijimbuluilu kia kikalakalu kia tokala ku kitumu kia ku tokala; (2) kijimbuluilu kia milongi ia ku tokala ni milongi i tua tokala ku sanga; (3) o ijimbuete iê, ni ijimbuete ia mutelembe uê; (4) ni izuelu i ua zuela kuila eie u xikina ni kidi kioso kuila o milongi ia ku tokala, ki i tokala ku ngana ia tokala, mba ku mukunji uê, mba ku kitumu kioso-kioso; ']

['(5) O kijimbuete kiê, ni kijimbuete kia ku tangela kuila o milongi iala mu kijimbuete kiki ia kidi, ni kuila eie uala ni kutena kua ku langa o ima ia ku tokala;']

['O kijimbuete kiki, ki tena ku kala ni kidimbu kiê, mba kijimbuete kia muthu ua mu tumina o ku ki jikula.']

['Se ku soneka o ima ioso íii, o ku tokuesa o maka mê kua-nda laleka.']

['Kuzuela ni Muthu']

['Tua ku dióndo, tu tumikise njimbu ni ibhuidisu mba jindunge.']

What causes alzheimer?

Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.

The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.

Some of the factors that may contribute to the development of Alzheimer's disease include:

1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.

2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.

3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.

4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.

5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.

6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.

7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.

8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.

9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.

It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.

Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.

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