What is pathophysiology of Heart attack?

['Kelg-y seb-kãngã']

Bõe n kɩtd tɩ sũ-sãang yõk neda?

Sũur bãag b sẽn boond me tɩ myocardial infarction wã wat n kɩtame tɩ zɩɩmã pa le tõe n kẽ sũurẽ wã sõma ye.

Woto yaa bũmb sẽn tõe n wa ne bãas a taaba. Wala makre, bãas a yiib sẽn tõe n wa ne bãas a taaba.

Yaa kolesterool, kaam, kalsiõ la fibrõn n be bãadã kõabẽ wã.

Zĩigã sã n pusgi, tõe n kɩtame tɩ zɩɩm gãand n lud kõbrã, tɩ zɩɩm ning sẽn tar pemsmã ra tõog n ta sũurẽ wã ye.

Yaa rẽ n kɩt tɩ sũ-sãamsã wat n tar paasgo.

Sãmpogrã sẽn ta zĩig ningã bee ne zɩɩmã sẽn kẽed zɩɩm-bogd nins sẽn pagã pʋgẽ wã, la wakat ning sẽn zĩnd bãagã sẽn yõk-a wã n tãag tɩbsgã.

Sũur bãagã tõe n kɩtame tɩ ned sũur sãame, wall a pa le tar laafɩ, a vʋʋsmã sã n pa nana, a sũur sãame, a lebg gãeemdo, a nusã, a yublã, a toogã bɩ a poorẽ wã sãame.

Naoor wʋsgo, b sã n dat n maag sũur bãaga, b segd n kɩtame tɩ zɩɩmã kẽed sũurẽ wã tao-tao.

Yaa tɩlae tɩ d bãng tɩ sũ-sãamsã sẽn wat ne bũmb ninsã yaa wʋsgo, la tɩ yɛl wʋsg n be n kɩt tɩ b wat ne-ba.

Ned sã n bẽed sũur bãaga, a tõe n bẽeda ne zɩɩm sẽn tar pãng wʋsgo, kõsterool sẽn yaa wʋsgo, sɩgaar yũubu, sɩgaar yũubu, bãas a taab sẽn tõe n wa ne bãas wala diabɛte, zɩslem sẽn loog noore, yĩn-wɩsgr kaalem, la ned zakẽ wã neb sẽn bẽed sũur bãaga.

Y sã n tõog n mao ne yɛl nins sẽn tõe n wa ne bãagã, tõe n sõngame tɩ y ra wa paam sũur bãag ye.

['Sõss sẽn tik Biiblã zugu']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Scott J: Pathophysiology and biochemistry of cardiovascular disease. Curr Opin Genet Dev. 2004, 14 (3): 271-9.

Liu Chung Ming C, Sesperez K, Ben-Sefer E, Arpon D, McGrath K, McClements L, Gentile C: Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease. Cells. 2021, 10 (4): .

Hansen J, Victor RG: Direct measurement of sympathetic activity: new insights into disordered blood pressure regulation in chronic renal failure. Curr Opin Nephrol Hypertens. 1994, 3 (6): 636-43.

LaMacchia JC, Roth MB: Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans. Am J Physiol Cell Physiol. 2015, 309 (2): C92-6.

Tham YK, Bernardo BC, Ooi JY, Weeks KL, McMullen JR: Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets. Arch Toxicol. 2015, 89 (9): 1401-38.

Lonn E: The clinical relevance of pharmacological blood pressure lowering mechanisms. Can J Cardiol. 2004, 20 Suppl B (): 83B-88B.

['Bãngr-gomde: logtoeemdã']

['Yaa zãmsg la kibay kũun yĩng bal la b yiisd sit kãngã, la pa logtoeemdã wɛɛngẽ sagls bɩ tʋʋm-sõng maaneg yĩng ye.']

['B pa segd n tũnug ne kɩbay nins b sẽn kõ wã n bao bãag bɩ zu-loɛɛg tɩɩm ye. Sẽn dat-b tɩbsg b toor segd n tɩ yãa logtor sẽn tar sor n tõe n tɩp-ba.']

['D tẽeg tɩ b sẽn maand to-to n leokd sogsgã to-to wã pa zems ye.']

['Y sã n wa karemd bũmb sẽn be sɩtã pʋgẽ, bɩ y ra tol n yĩm tɩ y segd n tɩ gesa logtor ye. Y sã n tagsdẽ tɩ y tara yĩn-wɩsgr yell bɩ y bool 911 wall y kẽng logtor yirã.']

['Bas-m-yam: sɛbã zãab wɛɛngẽ']

['Digital Millennium Copyright Act sẽn yaa yʋʋmd 1998 soabã, 17 U.S.C. § 512 (DMCA) kõta sor tɩ ned sã n tẽed tɩ bũmb sẽn be ẽntɛrnetã pʋgẽ kɩɩsda a sẽn tar sor n tõe n maan bũmb ninsã, a tõe n tɩ kos n paam n lebse.']

['Yãmb sã n tẽed ne pʋ-peelem tɩ bũmb sẽn be tõnd sɩt wɛɛbã pʋgẽ bɩ tõnd tʋʋm-noyã pʋsẽ n sãamd yãmb dʋrwa wã, yãmb (bɩ y tʋʋm-tʋmdã) tõe n toola tõnd koɛɛg n kos tɩ d yiis bũmbã wall d gɩdg tɩ y ra paam n kẽ ye.']

['B segd n tʋma koees ne ẽtɛrnetã (Ges-y ẽtɛrnetã adɛrs sẽn be babg ning sẽn yet tɩ "Tõnd sõsg zĩigã").']

['DMCA wã baoodame tɩ yãmb sẽn na n togs ned tɩ b maan-a-la bũmb sẽn kɩɩsd a sẽn tar sor n tõe n maan bũmb ningã, bɩ y wilg-a bũmb nins sẽn pʋgdã: 1) bũmb ning sẽn kɩt tɩ b maan-a bũmb ningã, 2) bũmb ning sẽn kɩt tɩ b maan-a bũmb ningã, la y wilg-d bũmb ning sẽn kɩt tɩ d tõe n bãng a sẽn be zĩig ninga. 3) y sẽn tõe n paam ned n gom ne-a to-to, n paas y adɛrsã, telefõnnã nimero, la y e-mailã. 4) y sã n yeel tɩ y kɩsa sɩd tɩ bũmb ning sẽn kɩt tɩ y maan bũmb ningã pa ned ning sẽn tar sor n tõe n maan bũmbã, bɩ a tʋm-tʋmdã, bɩ laloa wã sẽn kõ sor tɩ y maan ye.']

['5) Y sã n wa rat n wilg tɩ y pa tar sor n na n kɩɩs ned a to, bɩ y gʋls sebr n wilg tɩ y sẽn togsã yaa sɩda, la tɩ y tara sor n na n wilg tɩ nedã sẽn maan bũmb ning n kɩɩs yãmb dʋrwa rãmbã yaa sɩda.']

['La (6) sɛb nins sẽn tar-b sor n na n yiis sɛbã, bɩ ned sẽn tar sor n na n tʋm sɛbã yiisg yĩngã.']

['Y sã n pa gʋls kibay nins sẽn be yĩngrã, tõe n kɩtame tɩ y yẽgengã kaoos n pa sa ye.']

['Sõsg ne neda']

['Y sã n tar sokr bɩ y sẽn dat n bãnge, bɩ y gʋls-d lɛtr n tool-do.']

What is pathophysiology of heart attack?

The pathophysiology of a heart attack, also known as myocardial infarction, involves the disruption of blood flow to a part of the heart muscle, leading to the death of heart cells.

This typically occurs due to the obstruction of a coronary artery by a blood clot, which is often the result of atherosclerosis, a condition where plaque builds up in the arteries.

The plaque is made up of cholesterol, fatty substances, cellular waste products, calcium, and fibrin.

When a plaque ruptures, it can cause a blood clot to form, which can block the artery and prevent oxygen-rich blood from reaching the heart muscle.

This lack of oxygen causes the heart muscle cells to die, leading to a heart attack.

The extent of the damage depends on the size of the area supplied by the blocked artery and the time between the attack and treatment.

Symptoms of a heart attack can include chest pain or discomfort, shortness of breath, nausea, lightheadedness, and pain in the arms, neck, jaw, or back.

Treatment for a heart attack usually involves restoring blood flow to the heart muscle as quickly as possible, either through medication or procedures such as angioplasty and stenting or coronary artery bypass surgery.

It is important to note that the pathophysiology of a heart attack is complex and involves multiple factors, including genetic, lifestyle, and environmental factors.

Risk factors for heart attack include high blood pressure, high cholesterol, smoking, diabetes, obesity, lack of physical activity, and a family history of heart disease.

Managing these risk factors can help reduce the likelihood of experiencing a heart attack.

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