How is Alzheimer diagnosed?

['Whakarongo ki tēnei whārangi']

Me pēhea te tātaritanga o te mate a Alzheimer?

Ko te mate a Alzheimer e kitea ana ma te whakakotahitanga o nga tikanga, tae atu ki te aromatawai hauora, nga whakamatautau mohio me te neuropsychological, te whakaahua o te roro, me te tukanga o te whakakore i etahi atu take ka taea.

1. Arotake Hauora: Ka whakamātauria e te tākuta, ka tangohia hoki e ia he kōrero hōhonu mō te hītori hauora kia kore ai e kitea ētahi atu take e pā ana ki te ngaro o te mahara, te heke rānei o te mōhio, pēnei i ngā raruraru thyroid, te ngoikore o te huaora, te puku rānei.

2. Nga whakamātautau Cognitive me te neuropsychological: Ko enei whakamatautau e aromatawai ana i te mahara, te reo, te whakatau raru, me etahi atu mahi mohio ki te whakatau i te whanui o te ngoikoretanga mohio me te wehewehe i waenga i te ngaro o te mahara e pa ana ki te pakeke me te rewharewha.

3. Whakaahua roro: Ko te whakaata i te whakaata i te whakaata (MRI) te rorohiko tomography (CT) ranei ka awhina i te tautuhi i nga huringa hanganga i roto i te roro e tohu ana i te mate a Alzheimer.

Ka taea hoki te whakamahi i ngā karapa pūwhitiwhiti (PET) hei ine i ngā taumata o ētahi pūmua e pā ana ki te mate a Alzheimer.

4. Nga whakamātautau toto: Kua whakaaturia e nga rangahau o nāianei ka taea e ētahi whakamātautau toto te āwhina ki te tātaritanga i te mate a Alzheimer mā te ine i ngā taumata o ngā pūmua tauwhāiti, ngā tohu koiora rānei e pā ana ki te mate.

5. Te tukanga whakakore: I te mea kaore he whakamatautau kotahi mo te mate a Alzheimer, ko te taatai he maha nga wa ka uru ki te whakakore i etahi atu take pea o nga tohu-rite.

He mea nui kia mōhio ko te tātaritanga tūturu o te mate a Alzheimer ka taea anake i muri i te mate mā te whakamātautau o te kiko roro.

Heoi anō, ka taea e ngā tikanga tātaritanga o nāianei te whakarato i tētahi taumata tiketike o te tika mō te tātaritanga ā-rongoā i te wā e ora tonu ana te tangata.

He mea nui te tātaritanga wawe hei tīmata i te maimoatanga me te whakamahere mō te heke mai.

['Ngā tohutoro']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Liu SS, Zhu SQ: [Correlation between Alzheimer disease and cataract]. Zhonghua Yan Ke Za Zhi. 2017, 53 (4): 314-316.

Gauthier S: Practical guidelines for the antemortem diagnosis of senile dementia of the Alzheimer type. Prog Neuropsychopharmacol Biol Psychiatry. 1985, 9 (5-6): 491-5.

Rubin R: New Test to Help Diagnose Alzheimer Disease. JAMA. 2022, 327 (23): 2281.

[Blood Based Biomarker for Optimization of Early and Differential Diagnosis of Alzheimer's Dementia]. Fortschr Neurol Psychiatr. 2022, 90 (7-08): 326-335.

Kapp MB: Physicians' legal duties regarding the use of genetic tests to predict and diagnose Alzheimer disease. J Leg Med. 2000, 21 (4): 445-75.

Britschgi M, Wyss-Coray T: Blood protein signature for the early diagnosis of Alzheimer disease. Arch Neurol. 2009, 66 (2): 161-5.

Volicer L, Berman SA, Cipolloni PB, Mandell A: Persistent vegetative state in Alzheimer disease. Does it exist? Arch Neurol. 1997, 54 (11): 1382-4.

Imabayashi E, Saitoh Y, Tsukamoto T, Sakata M, Takano H: Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18 F-THK5351. Clin Nucl Med. 2022, 47 (12): 1066-1068.

Martínez A, Lahiri DK, Giacobini E, Greig NH: Advances in Alzheimer therapy: understanding pharmacological approaches to the disease. Curr Alzheimer Res. 2009, 6 (2): 83-5.

['Whakakahoretanga: hauora']

['Ko tenei paetukutuku e whakaratohia ana mo nga kaupapa ako me nga korero anake, kaore hoki e whakarato i nga tohutohu hauora, i nga ratonga ngaio ranei.']

['Kaua e whakamahia ngā mōhiohio e whakaratohia ana hei tātaritanga, hei whakaora rānei i tētahi raruraru hauora, mate rānei, ā, ko te hunga e rapu ana i te tohutohu hauora whaiaro me kōrero ki tētahi tākuta whai raihana.']

['Kia mōhio mai koe ko te whatunga pūtau e whakaputa ana i ngā whakautu ki ngā pātai, he tino hē ina tae mai ki te ihirangi tau. Hei tauira, ko te tokomaha o ngā tāngata kua tohua he mate tauwhāiti.']

['Me rapu tonu i te tohutohu a tō tākuta, i tētahi atu kaiwhakarato hauora whai tohu rānei e pā ana ki tētahi mate hauora. Kaua rawa e whakahawea ki te tohutohu hauora ngaio, te whakaroa rānei ki te rapu i te mea nā tētahi mea i pānuihia e koe i tēnei paetukutuku. Ki te whakaaro koe he mate hauora ohorere pea koe, waea atu ki te 911 ka haere ki te rūma ohorere tata tonu. Kāore he hononga tākuta-tūroro i hangaia e tēnei paetukutuku, i tōna whakamahinga rānei. Kāore a BioMedLib, ōna kaimahi rānei, tētahi kaitohutohu rānei ki tēnei paetukutuku, e whakaatu ana, e tohu ana rānei, e pā ana ki ngā mōhiohio e whakaratohia ana i konei, ki tōna whakamahinga rānei.']

['Whakakahoretanga: mana pupuri']

['Ko te Ture Mana pupuri Mamati Mamati o te tau 1998, 17 U.S.C. § 512 (te DMCA) e whakarato ana i te whakahoki mo nga rangatira mana pupuri e whakapono ana ko nga rauemi e puta ana i runga i te Ipurangi e takahi ana i o raatau mana i raro i te ture mana pupuri a US. ']

['Mēnā e whakapono pono ana koe e takahi ana tētahi ihirangi, rauemi rānei e wātea ana i runga i tō mātou paetukutuku, ratonga rānei i tō mana pupuri, ka taea e koe (tō māngai rānei) te tuku pānui ki a mātou e tono ana kia tangohia te ihirangi, rauemi rānei, kia āraia rānei te uru atu ki a ia. ']

["Me tuku ngā whakamōhiotanga ā-tuhi mā te īmēra (tirohia te wāhanga 'Whakapā' mō te wāhitau īmēra). "]

['E hiahiatia ana e te DMCA kia whakaurua ki tō whakamōhiotanga mō te whakawātea mana pupuri i ngā mōhiohio e whai ake nei: (1) whakaahuatanga o te mahi mana pupuri e pā ana ki te whakawātea e whakapaetia ana; (2) whakaahuatanga o te ihirangi e whakapaetia ana e takahi ana me ngā mōhiohio e tika ana kia taea ai e mātou te kimi i te ihirangi; (3) mōhiohio whakapā mōu, tae atu ki tō wāhitau, tau waea me tō wāhitau īmēra; (4) he tauākī nāu e whakapono pono ana koe kāore te ihirangi i te āhua e amuamutia ana i whakamanahia e te kaipupuri mana pupuri, e tana māngai rānei, e te whakahaerenga rānei o tētahi ture; ']

['(5) he tauākī nāu i haina, i raro i te whiu o te whakapae teka, e tika ana ngā mōhiohio i roto i te whakamōhiotanga, ā, kei a koe te mana ki te whakatinana i ngā mana pupuri e kīia ana kua takahia;']

['me te (6) he waitohu ā-tinana, ā-rorohiko rānei a te kaipupuri mana pupuri, a tētahi tangata rānei kua whakamanahia ki te mahi mō te kaipupuri mana pupuri. ']

['Ki te kore e whakaurua ngā mōhiohio katoa i runga ake nei, ka whakaroa pea te tukatuka o tō amuamu.']

['Whakapā']

['Tena koa tukuna mai he imeera ki a maatau me tetahi patai / whakaaro.']

How is alzheimer diagnosed?

Alzheimer's disease is diagnosed through a combination of methods, including a thorough medical evaluation, cognitive and neuropsychological tests, brain imaging, and the process of elimination of other possible causes.

1. Medical evaluation: A doctor will perform a physical examination and take a detailed medical history to rule out other possible causes of memory loss or cognitive decline, such as thyroid problems, vitamin deficiencies, or brain tumors.

2. Cognitive and neuropsychological tests: These tests assess memory, language, problem-solving, and other cognitive functions to determine the extent of cognitive impairment and to differentiate between normal age-related memory loss and dementia.

3. Brain imaging: Magnetic resonance imaging (MRI) or computed tomography (CT) scans can help identify structural changes in the brain that may indicate Alzheimer's disease.

Positron emission tomography (PET) scans can also be used to measure the levels of certain proteins associated with Alzheimer's disease.

4. Blood tests: Recent research has shown that certain blood tests can help diagnose Alzheimer's disease by measuring the levels of specific proteins or biomarkers associated with the disease.

5. Process of elimination: Since there is no single definitive test for Alzheimer's disease, diagnosis often involves ruling out other possible causes of dementia-like symptoms.

It is important to note that a definitive diagnosis of Alzheimer's disease can only be made after death through an examination of brain tissue.

However, current diagnostic methods can provide a high level of certainty for a clinical diagnosis while the person is still alive.

Early diagnosis is important for starting treatment and planning for the future.

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