Pathophysiology ya kankere ya prostate e šupa mekgwa le ditshepedišo tšeo di bakago go tšwelela le go tšwela pele ga bolwetši.
Kankere ya prostate ke serurugi se kotsi seo se tšwago diseleng tša prostate gland, yeo e lego setho se senyenyane sa sebopego sa walnut seo se lego ka tlase ga senya sa banna.
Kgeleswa ya prostate e tšweletša seela sa peu, seo se fepago le go iša peu.
Lebaka la kgonthe la kankere ya prostate ga le kwešišwe ka mo go feletšego, eupša go na le dilo tše mmalwa tšeo di tsebjago tšeo di oketšago kotsi ya go ba le bolwetši bjo.
Tše di akaretša nywaga, histori ya lapa, morafo le diphetogo tše itšego tša leabela.
Kankere ya prostate e tlwaelegile kudu go banna ba bagolo, gomme bontši bja batho bao ba nago le yona ke ba nywaga ya ka godimo ga e 65.
Go oketša moo, banna bao ba nago le histori ya lapa ya kankere ya prostate ba kotsing e kgolo, go etša banna ba ma-Afrika ba Amerika le banna ba setlogo sa Caribbean.
Pathophysiology ya kankere ya prostate e akaretša go gola mo go sa laolegego le go arogana ga disele ka gare ga prostate gland.
Se se ka direga ka baka la diphetogo tša leabela tšeo di lebišago go bontšheng kudu ga dilo tše itšego tša go gola goba go se šome ga dikarolwana tša leabela tšeo di thibelago go gola ga serurugi.
Diphetogo tše di ka feleletša ka go gola mo go sa laolegego ga disele, gwa lebiša go bopegeng ga serurugi.
Ge serurugi se dutše se gola, se ka hlasela dithishu le ditho tša kgaufsi, tše bjalo ka senya, mogodu le di-lymph node tša kgaufsi.
Mabakeng a mangwe, disele tša kankere di ka tšwa go serurugi sa mathomo gomme tša phatlalala dikarolong tše dingwe tša mmele ka madi goba ka tshepedišo ya lymphatic, e lego mogato wo o tsebjago e le metastasis.
Ge kankere e šetše e phatlaletše, go ka ba thata kudu go e alafa.
Kankere ya prostate gape e ka tutuetšwa ke dilo tša dihoromone, kudu-kudu testosterone ya androgen.
Testosterone e ka tutueletša go gola ga disele tša kankere ya prostate, gomme dikalafo tše dintši tša kankere ya prostate di ikemišeditše go fokotša tekanyo ya hormone ye goba go thibela ditla-morago tša yona.
Ka boripana, pathophysiology ya kankere ya prostate e akaretša kgolo e sa laolegego le go arogana ga disele ka gare ga prostate gland, tšeo di ka tutuetšwago ke dikarolwana tša leabela, dihoromone le dilo tša tikologo.
Go kwešiša mekgwa ya motheo ya bolwetši go bohlokwa bakeng sa go hlama dikalafo tše di šomago le go kaonefatša mafelelo a balwetši ba kankere ya prostate.
Zobniw CM, Causebrook A, Fong MK: Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer. Res Rep Urol. 2014, 6 (): 97-105.
Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.
Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.
Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.
Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.
Kotani K, Sekine Y, Ishikawa S, Ikpot IZ, Suzuki K, Remaley AT: High-density lipoprotein and prostate cancer: an overview. J Epidemiol. 2013, 23 (5): 313-9.
Jadvar H: Molecular imaging of prostate cancer: a concise synopsis. Mol Imaging. , 8 (2): 56-64.
['Boikano: bja tša kalafo']
['Wepesaete ye e neetšwe feela bakeng sa go ruta le go nea tsebišo gomme ga e nee keletšo ya tša kalafo goba ditirelo tša tša kalafo.']
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["Ditsebišo di swanetše go romelwa ka go ngwala ka emeile (lebelela karolo ya 'Kgokagano' go hwetša aterese ya emeile). "]
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['(5) setatamente sa gago, seo se saennwego ka tlase ga kotlo ya go bolela maaka, gore tshedimošo yeo e lego tsebišong e nepagetše le gore o na le maatla a go phethagatša ditokelo tša mongwadi tšeo go thwego di a gatakelwa; ']
['le (6) tshaeno ya kgonthe goba ya elektroniki ya mong wa tokelo ya ngwalollo goba motho yo a dumeletšwego go dira legatong la mong wa tokelo ya ngwalollo. ']
['Go palelwa ke go akaretša tshedimošo ka moka ya ka godimo go ka dira gore go šongwa ga ngongorego ya gago go diege.']
['Go Ikgokaganya']
['Re romele imeile ka kgopelo le ge e le efe goba tšhišinyo.']
What is pathophysiology of prostate cancer?
The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.
Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.
The prostate gland produces seminal fluid, which nourishes and transports sperm.
The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.
These include age, family history, race, and certain genetic mutations.
Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.
Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.
The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.
This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.
These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.
As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.
In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.
Once the cancer has spread, it can be more difficult to treat.
Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.
Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.
In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.
Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.
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