Urticaria, yeo e tsebjago e le dikgofa, ke boemo bja letlalo bjo bo hlaolwago ke go tšwelela ga go hlohlona, go gola, go ba le dikgofa tše dihubedu letlalong.
Pathophysiology ya urticaria e akaretša go lokollwa ga histamine le dilo tše dingwe tšeo di hlolago go ruruga go tšwa go di-mast cell, tšeo e lego disele tša go lwantšha malwetši tšeo di hwetšwago letlalong le dithong tše dingwe.
Ge go na le urticaria e šoro, go lokollwa ga histamine le dilo tše dingwe go hlohleletšwa ke go arabela ga motho go selo se itšego seo se bakago go se kwa gabotse, bjalo ka dijo, dihlare goba go longwa ke dikhunkhwane.
Se se dira gore disele tša mast di se sa ba le dithoro, di lokolle histamine le dilo tše dingwe tšeo di dirago gore madi a tsene ka gare ga ditšhika, e lego seo se feleletšago ka go bopega ga di-wheel.
Ka go urticaria e sa folego, sebaki gantši ga se tsebje, eupša go naganwa gore se tswalana le tshepedišo ya go lwantšha malwetši a mmele.
Mo lebakeng le, mmele o tšweletša di-autoantibody tšeo di hlaselago high-affinity IgE receptor (FcεRI) go di-mast cell, e lego seo se lebišago go go šoma ga tšona le go lokollwa ga histamine le di-mediator tše dingwe.
Ka bobedi bja urticaria e šoro le e sa folego, go lokollwa ga histamine le dilo tše dingwe go baka dika tša go hlohlona, go hwibila le go ruruga.
Kalafo gantši e akaretša go dirišwa ga di-antihistamine go thibela ditla-morago tša histamine le go fokotša maswao.
Mabakeng a šoro, dihlare tše dingwe tše bjalo ka corticosteroids goba omalizumab di ka dirišwa go laola boemo.
Wahlgren CF: Pathophysiology of itching in urticaria and atopic dermatitis. Allergy. 1992, 47 (2 Pt 1): 65-75.
Raap U, Liekenbröcker T, Wieczorek D, Kapp A, Wedi B: [New therapeutic strategies for the different subtypes of urticaria]. Hautarzt. 2004, 55 (4): 361-6.
[Recommendations for the diagnosis and treatment of urticaria in children]. Arch Argent Pediatr. 2021, 119 (2): S54-S66.
Brzoza Z, Grzeszczak W, Rogala B, Trautsolt W, Moczulski D: Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Allergol Immunopathol (Madr). , 42 (4): 302-6.
Sweeney TM, Dexter WW: Cholinergic urticaria in a jogger: ruling out exercise-induced anaphylaxis. Phys Sportsmed. 2003, 31 (6): 32-6.
['Boikano: bja tša kalafo']
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['(5) setatamente sa gago, seo se saennwego ka tlase ga kotlo ya go bolela maaka, gore tshedimošo yeo e lego tsebišong e nepagetše le gore o na le maatla a go phethagatša ditokelo tša mongwadi tšeo go thwego di a gatakelwa; ']
['le (6) tshaeno ya kgonthe goba ya elektroniki ya mong wa tokelo ya ngwalollo goba motho yo a dumeletšwego go dira legatong la mong wa tokelo ya ngwalollo. ']
['Go palelwa ke go akaretša tshedimošo ka moka ya ka godimo go ka dira gore go šongwa ga ngongorego ya gago go diege.']
['Go Ikgokaganya']
['Re romele imeile ka kgopelo le ge e le efe goba tšhišinyo.']
What is pathophysiology of urticaria?
Urticaria, commonly known as hives, is a skin condition characterized by the appearance of itchy, raised, red welts (wheals) on the skin.
The pathophysiology of urticaria involves the release of histamine and other inflammatory mediators from mast cells, which are immune cells found in the skin and other tissues.
In acute urticaria, the release of histamine and other mediators is triggered by an allergic reaction to a specific allergen, such as food, medication, or insect sting.
This causes the mast cells to degranulate, releasing histamine and other mediators that cause blood vessels to become leaky, leading to the formation of wheals.
In chronic urticaria, the cause is often unknown, but it is thought to be related to an autoimmune mechanism.
In this case, the body produces autoantibodies that target the high-affinity IgE receptor (FcεRI) on mast cells, leading to their activation and the release of histamine and other mediators.
In both acute and chronic urticaria, the release of histamine and other mediators leads to the characteristic symptoms of itching, redness, and swelling.
Treatment typically involves the use of antihistamines to block the effects of histamine and reduce symptoms.
In severe cases, other medications such as corticosteroids or omalizumab may be used to control the condition.
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