Kodi pathophysiology ya khansa ya m'mawere ndi yotani?
Pathophysiology ya khansa ya m'mawere imatanthauza kusintha kwachilendo m'machitidwe ndi machitidwe abwinobwino a m'thupi omwe amapezeka pakukula ndi kupita patsogolo kwa khansa ya m'mawere.
Zimaphatikizapo kuphunzira za njira za zamoyo ndi za mamolekyu zimene zimapangitsa maselo a khansa kukula mosalamulirika ndi kufalikira m'matumbo a m'mawere.
Zimenezi zikuphatikizapo zinthu za chibadwa, za chibadwa, ndi za m'chilengedwe zimene zimayambitsa, kulimbikitsa, ndi kupititsa patsogolo khansa ya m'mawere.
Zina mwa kusintha kwakukulu kwa pathophysiological mu khansa ya m'mawere zikuphatikizapo:
1. Kusintha kwa majini: Kusintha kwa majini ena, monga BRCA1 ndi BRCA2, kungawonjezere chiopsezo cha kukhala ndi khansa ya m'mawere.
Kusinthasintha kumeneku kungabweredwe ndi choloŵa kapena kupezedwa m'moyo wa munthu.
2. Kusagwirizana kwa mahomoni: Mahomoni, makamaka estrogen, angakhale ndi mbali m'kupanga ndi kukula kwa khansa ya m'mawere.
Kusagwirizana kwa mlingo wa mahomoni kapena kugwiritsira ntchito estrogen mopambanitsa kungawonjezere chiopsezo cha kansa ya m'mawere.
3. Kutupa: Kutupa kosatha mu minofu ya m'mawere kungathandize kuti khansa ya m'mawere ipangike mwa kulimbikitsa kukula ndi kupulumuka kwa maselo a khansa.
4. Malo ozungulira chotupa: Malo ozungulira chotupacho, kuphatikizapo extracellular matrix, maselo a chitetezo cha m'thupi, ndi mitsempha ya magazi, angakhudze kukula ndi kufalikira kwa khansa ya m'mawere.
5. Metastasis: Khansa ya m'mawere ingafalikire ku mbali zina za thupi kupyolera mu dongosolo la lymphatic kapena mwazi, kutsogolera ku mapangidwe a zotupa zachiŵiri m'ziwalo zakutali.
Kumvetsetsa pathophysiology ya khansa ya m'mawere n'kofunika kwambiri popanga njira zothandizira kupewa, kuzindikira msanga, ndi kuchiza.
Underwood SM: Breast cancer in African American women: nursing essentials. ABNF J. , 17 (1): 3-14.
Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.
Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
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Chonde titumizireni imelo ndi funso / lingaliro lililonse.
What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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