La fisiopatologia del càncer de la popa fa referéncia als cambiaments anormals dins los procediments e mecanismes fisiologics normals que se produson dins lo desvelopament e la progression del càncer de la popa.
Implica l'estudi dels mecanismes biologics e moleculars que menan a la creissença e propagacion non contrarotlada de las cellulas cancerosas dins lo teissut del sen.
Aquò inclutz los factors genetics, epigenetics, e environamentals que contribuisson a l'iniciacion, promocion, e progression del càncer de la popa.
De cambiaments fisiopatologics claus dins lo càncer del sen incluson:
1. Mutacions geneticas: las mutacions dins de gèns coma BRCA1 e BRCA2 pòdon aumentar lo risc de desvelopar un càncer de la popa.
Aquelas mutacions pòdon èsser eretadas o aqueridas pendent la vida de la persona.
2. desequilibris ormonals: Las ormonas, subretot l'estrogèn, pòdon jogar un ròtle dins lo desvelopament e creissement del càncer de la popa.
Un desequilibri dins los nivèls ormonals o l'exposicion a un excès d'estrogèn pòt aumentar lo risc de càncer de la popa.
3. Inflamacion: L'inflamacion cronica del teissut del sen pòt contribuir al desvelopament del càncer del sen per la creissença e la subrevida de las cellulas cancerosas.
4. Microenvironament de la tumor: L'environament a l'entorn de la tumor, coma la matritz extracellulara, las cellulas immunitàrias, e los vasos sanguins, pòdon influenciar la creissença e espandiment del càncer de la popa.
5. Metastasi: Lo càncer del sen pòt s'espandir a d'autras partidas del còs pel sistèma linfatic o circulacion sanguina, menant a la formacion de tumors segondaris dins los organs aluenhats.
Comprene la fisiopatologia del càncer del sen es crucial per desvolopar una prevencion eficaça, deteccion primairenca, e estrategias de tractament.
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What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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