Say pathophysiology na colon cancer et ontutukoy ed saray manunan proseso ya pansesengegan na iyaaligwas na colon cancer.
Say colon cancer, a kabkabat met bilang colorectal cancer, et sakey a klase na kanser a onggagapo ed colon odino rectum, a kabiangan na baleg ya eges.
Kaslakan et onggagapo itan ed sakey a polyp, a diad ilabas na panaon et magmaliw a kanser.
Say pathophysiology na colon cancer et nalalanor so pigaran sengegan, kaiba lay genetic mutation, inflammation, tan saray sengegan ed kaliberliber.
Nayarin wala ray mutation ed DNA na selula na colon, kanian agla nakontrol so ibaleg tan panlalaok na selula.
Sarayan mutation et nayarin natawir odino niwala, tan nayarin mangapekta ed nanduruman gene a nalalanor ed ibabaleg, pambabaleg, tan pan-apiger na selula.
Say inflammation ed colon, ya nayarin resulta na inflammatory bowel disease, et nayarin mamawala met na colon cancer.
Say graben panotot et nayarin manresulta ed pakawalaay kemikal ya mamapabaleg tan mamapaldua ed selula, a nayarin pansengegan na cancer.
Saray sengegan ed kaliberliber, a singa say panangan, estiloy kabibilay, tan pakaka-ekspo ed pigaran kemikal, so nayarin pansengegan met na colon cancer.
Alimbawa, say pangan na dakel a karne tan karne ya pinatambalan et nayarin pansengegan na colon cancer.
Arum nin sengegan, a singa say inkabaleg, panagsigarilyo, tan kakulangan na pisikal ya aktibidad, so mamaaligwas met ed kapeligroan.
No wala lay colon cancer, nayarin onkayat itan ed nanduruman stage, manlapud say cancer ya wala nid colon anggad saray cancer ya onkayat ed arum a parte na laman.
Nayarin onkayat iray selula na kanser ed asingger iran tissue tan organ, tan nayarin onkayat met iratan ed lymphatic system odino diad dala ya anggad ararawin lugar, a singa say altey odino bala.
Say panagtambal ed colon cancer et kaslakan ya kaiba so operasyon, chemotherapy, tan radiation therapy, depende ed stage tan lugar na cancer.
Importante so masakbay a pakaamta tan panagtambal pian mas maong so pansumpalan, lapud say colon cancer et nayarin natambal no naamtaan itan ed masakbay iran yugto.
Say regular a pan-eksamin, a singa say colonoscopy, so makatulong pian naamtaan so colon cancer diad sankaunaan iran yugto na satan, sano mainomay la itan a tambalen.
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Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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