Ny fisiôlôjia momba ny homamiadan'ny nono dia manondro ny fiovana tsy ara-dalàna amin'ny fizotra ara-batana sy ny rafitra mahazatra mitranga amin'ny fivoarana sy ny fivoaran'ny homamiadan'ny nono.
Tafiditra ao anatin'izany ny fandalinana ny rafitra biolojika sy molekiola fototra izay mitarika amin'ny fitomboana tsy voafehy sy ny fiparitahan'ny sela homamiadana ao amin'ny tavy nono.
Anisan'izany ny fototarazo, ny epigenetika, ary ny tontolo iainana izay manampy amin'ny fanombohana, ny fampiroboroboana ary ny fivoaran'ny homamiadan'ny nono.
Ny sasany amin'ireo fiovana lehibe amin'ny pathophysiological amin'ny homamiadan'ny nono dia misy:
1. Fiovan'ny fototarazo: Mety hampitombo ny mety ho voan'ny kanseran'ny nono ny fiovan'ny fototarazo sasany, toy ny BRCA1 sy BRCA2.
Mety ho nolovana na azo nandritra ny androm-piainan'ilay olona ireo fiovana ireo.
2. Tsy mifandanja ny hormonina: Mety hisy vokany eo amin'ny fivoaran'ny kanseran'ny nono ny hormonina, indrindra fa ny estrogen.
Mety ho voan'ny kanseran'ny nono koa ny vehivavy, raha tsy mitovy ny fatran'ny hormonina ao aminy.
3. Miteraka fivontosana: Mety hahatonga ny kanseran'ny nono ny fivontosana maharitra ao amin'ny nonon'ny nono, satria mampitombo sy mampitombo ny sela misy an'ilay kansera.
4. Ny manodidina ny fivontosana: Mety hisy vokany eo amin'ny fitomboan'ny kanseran'ny nono sy ny fiparitahany ny manodidina ny fivontosana, anisan'izany ny sela ivelan'ny sela, ny sela miaro amin'ny aretina, ary ny lalan-dra.
5. Miely: Mety hiparitaka any amin'ny faritra hafa amin'ny vatana ny kanseran'ny nono, amin'ny alalan'ny lalan-dra na ny lalan-dra, ka miteraka fivontosana any amin'ny taova hafa.
Tena ilaina ny fahafantarana ny fizika sy ny aretina ateraky ny homamiadan'ny nono mba hahafahana misoroka, mamantatra mialoha, ary mitsabo amin'ny fomba mahomby.
Underwood SM: Breast cancer in African American women: nursing essentials. ABNF J. , 17 (1): 3-14.
Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.
Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
['Fialana andraikitra: fitsaboana']
['Natao hampianarana sy hampahafantarana fotsiny ity tranonkala ity, fa tsy natao hanomezana torohevitra ara-pitsaboana na tolotra matihanina.']
['Tsy tokony hampiasaina mba hamantarana na hitsaboana olana ara-pahasalamana na aretina ny fanazavana omena, ary tokony hanatona dokotera manana fahazoan-dalana hitsabo tena ireo mitady torohevitra ara-pitsaboana.']
["Mariho tsara fa ny tambajotra neural izay mamorona ny valin'ny fanontaniana, dia tsy marina indrindra raha resaka isa no resahina. Ohatra, ny isan'ny olona voamarina fa voan'ny aretina manokana."]
["Mitadiava torohevitra avy amin'ny dokotera na mpitsabo hafa mahay momba ny toe-pahasalamanao. Aza atao tsinontsinona mihitsy ny torohevitra ara-pitsaboana matihanina na manemotra ny fikatsahana azy noho ny zavatra novakianao tao amin'ity tranonkala ity. Raha mieritreritra ianao fa mety manana vonjy taitra ara-pitsaboana, antsoy ny 911 na mandehana any amin'ny efitrano fitsaboana maika akaiky indrindra avy hatrany. Tsy misy fifandraisana mpitsabo-marary noforonin'ity tranonkala ity na ny fampiasana azy. Na ny BioMedLib na ny mpiasa ao aminy, na ny mpandray anjara amin'ity tranonkala ity, dia tsy manao fanambarana, mazava na tsy mazava, momba ny fampahalalana omena eto na ny fampiasana azy."]
["Fanamarihana: zon'ny mpamorona"]
["Ny Digital Millennium Copyright Act of 1998, 17 U.S.C. § 512 (ny DMCA) dia manome vahaolana ho an'ireo tompon'ny zon'ny mpamorona izay mino fa manitsakitsaka ny zony araka ny lalàna momba ny zon'ny mpamorona ao Etazonia ny fitaovana hita ao amin'ny Internet. "]
["Raha mino ianao fa misy votoaty na fitaovana azo ampiasaina amin'ny tranonkalanay na ny tolotra ataonay manitsakitsaka ny zon'ny mpamorona anao, dia afaka mandefa filazana aminay ianao (na ny mpandraharaha anao) mangataka ny hanesorana ny votoaty na ny fitaovana, na ny fanakanana ny fidirana amin'izany. "]
['Tsy maintsy alefa an-tsoratra amin\'ny alalan\'ny mailaka ny filazana (jereo ny fizarana "Contact" raha mila adiresy mailaka). ']
["Ny DMCA dia mitaky ny fampandrenesanao ny voalaza ho fanitsakitsahana ny zon'ny mpamorona ahitana ireto fampahalalana manaraka ireto: (1) famaritana ny asa voaaro zon'ny mpamorona izay voalaza fa voahitsakitsaka; (2) famaritana ny votoaty voalaza fa manitsakitsaka sy fampahalalana ampy ahafahantsika mahita ny votoatiny; (3) fampahalalana momba anao, anisan'izany ny adiresinao, nomeraon-telefaona ary adiresy mailaka; (4) fanambarana avy aminao fa mino tsara ianao fa ny votoaty amin'ny fomba nitarainana dia tsy nomen'ny tompon'ny zon'ny mpamorona alalana, na ny mpandraharahany, na amin'ny asan'ny lalàna rehetra; "]
["(5) fanambarana nosoniavinao, eo ambany sazin'ny fianianana diso, fa marina ny vaovao ao amin'ny fampahafantarana ary manana fahefana hampihatra ny zon'ny mpamorona izay voalaza fa voahitsakitsaka ianao; "]
["Mety hiteraka fahatarana amin'ny fikarakarana ny fitarainanao ny tsy fampidirana ireo vaovao rehetra voalaza etsy ambony."]
['Fifandraisana']
['Alefaso mailaka izahay raha misy fanontaniana / sosokevitra.']
What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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['Manodidina ny']
['Mampiasa solosaina mandeha ho azy (algoritma fianarana milina) ny BioMedLib mba hamoronana fanontaniana sy valiny.']
["Manomboka amin'ny famoahana biomedika 35 tapitrisa ao amin'ny PubMed/Medline izahay. ary koa ny pejin'ny tranonkala RefinedWeb."]
