Inona ny fisiopatolojian'ny homamiadan'ny havokavoka?
Ny pathophysiology (fiasan'ny vatana) amin'ny homamiadan'ny havokavoka dia manondro ny fiovana amin'ny fizotra sy ny fomba fiasa ara-batana mahazatra mitranga amin'ny fivoarana sy ny fivoaran'ny homamiadan'ny havokavoka.
Aretina sarotra ny homamiadan'ny havokavoka, izay vokatry ny fitomboana sy fizarazarana tsy voafehy ataon'ny sela tsy ara-dalàna ao amin'ny havokavoka.
Mety hiforona fivontosana ireny sela ireny, ary hiparitaka any amin'ny faritra hafa amin'ny vatana, ka hiteraka soritr'aretina sy fahasarotana isan-karazany.
Misy antony maro ny pathophysiology momba ny homamiadan'ny havokavoka, anisan'izany ny fiovan'ny fototarazo, ny tontolo iainana, ary ny fomba fiaina.
Mety hisy fiovan'ny fototarazo ao amin'ny ADN ao amin'ny sela ao amin'ny havokavoka, ka miteraka fitomboana sy fizarazarana tsy voafehy.
Mety ho nolovana na azo ireny fiovana ireny, ary mety ho vokatry ny setroka, radon, asbestos, ary ny loto avy amin'ny rivotra.
Azo sokajiana ho karazany roa ny homamiadan'ny havokavoka: homamiadan'ny havokavoka sela kely (SCLC) sy homamiadan'ny havokavoka sela tsy kely (NSCLC).
Mety tsy hitovy ny pathophysiology amin'ireo karazana homamiadan'ny havokavoka ireo, satria samy manana ny fiovan'ny fototarazo samihafa izy ireo ary samy hafa ny valin'ny fitsaboana.
Ny pathophysiology momba ny homamiadan'ny havokavoka dia misy ifandraisany amin'ny fifandraisan'ny sela homamiadana sy ny sela manodidina, anisan'izany ny hery fiarovana.
Afaka mandositra ny hery fiarovana ny sela homamiadana, ka mamela azy hitombo sy hiparitaka tsy voafehy.
Ankoatra izany, afaka mampiroborobo ny fitomboan'ny fivontosana sy ny fivontosana ny microenvironment amin'ny fivontosana amin'ny alalan'ny fanomezana tontolo manohana ny sela homamiadana.
Ny pathophysiology momba ny homamiadan'ny havokavoka dia dingana sarotra sy mavitrika, ary miasa tsy tapaka ny mpikaroka mba hahatakarana tsara kokoa ny rafitra fototra mba hampivelarana fitsaboana mahomby kokoa sy hanatsarana ny valin'ny marary.
Li Z, Qian Y, Li W, Liu L, Yu L, Liu X, Wu G, Wang Y, Luo W, Fang F, Liu Y, Song F, Cai Z, Chen W, Huang W: Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020, 23 (8): 101411.
Nurwidya F, Syahruddin E, Yunus F: Pain management in lung cancer. Adv Respir Med. 2016, 84 (6): 331-336.
Khan KA, Kennedy MP, Moore E, Crush L, Prendeville S, Maher MM, Burke L, Henry MT: Radiological characteristics, histological features and clinical outcomes of lung cancer patients with coexistent idiopathic pulmonary fibrosis. Lung. 2015, 193 (1): 71-7.
Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A: Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. Int J Mol Sci. 2022, 23 (21): .
Lee D, Kim Y, Chung C: Scientific Validation and Clinical Application of Lung Cancer Organoids. Cells. 2021, 10 (11): .
Mucchietto V, Crespi A, Fasoli F, Clementi F, Gotti C: Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des. 2016, 22 (14): 2160-9.
['Fialana andraikitra: fitsaboana']
['Natao hampianarana sy hampahafantarana fotsiny ity tranonkala ity, fa tsy natao hanomezana torohevitra ara-pitsaboana na tolotra matihanina.']
['Tsy tokony hampiasaina mba hamantarana na hitsaboana olana ara-pahasalamana na aretina ny fanazavana omena, ary tokony hanatona dokotera manana fahazoan-dalana hitsabo tena ireo mitady torohevitra ara-pitsaboana.']
["Mariho tsara fa ny tambajotra neural izay mamorona ny valin'ny fanontaniana, dia tsy marina indrindra raha resaka isa no resahina. Ohatra, ny isan'ny olona voamarina fa voan'ny aretina manokana."]
["Mitadiava torohevitra avy amin'ny dokotera na mpitsabo hafa mahay momba ny toe-pahasalamanao. Aza atao tsinontsinona mihitsy ny torohevitra ara-pitsaboana matihanina na manemotra ny fikatsahana azy noho ny zavatra novakianao tao amin'ity tranonkala ity. Raha mieritreritra ianao fa mety manana vonjy taitra ara-pitsaboana, antsoy ny 911 na mandehana any amin'ny efitrano fitsaboana maika akaiky indrindra avy hatrany. Tsy misy fifandraisana mpitsabo-marary noforonin'ity tranonkala ity na ny fampiasana azy. Na ny BioMedLib na ny mpiasa ao aminy, na ny mpandray anjara amin'ity tranonkala ity, dia tsy manao fanambarana, mazava na tsy mazava, momba ny fampahalalana omena eto na ny fampiasana azy."]
["Fanamarihana: zon'ny mpamorona"]
["Ny Digital Millennium Copyright Act of 1998, 17 U.S.C. § 512 (ny DMCA) dia manome vahaolana ho an'ireo tompon'ny zon'ny mpamorona izay mino fa manitsakitsaka ny zony araka ny lalàna momba ny zon'ny mpamorona ao Etazonia ny fitaovana hita ao amin'ny Internet. "]
["Raha mino ianao fa misy votoaty na fitaovana azo ampiasaina amin'ny tranonkalanay na ny tolotra ataonay manitsakitsaka ny zon'ny mpamorona anao, dia afaka mandefa filazana aminay ianao (na ny mpandraharaha anao) mangataka ny hanesorana ny votoaty na ny fitaovana, na ny fanakanana ny fidirana amin'izany. "]
['Tsy maintsy alefa an-tsoratra amin\'ny alalan\'ny mailaka ny filazana (jereo ny fizarana "Contact" raha mila adiresy mailaka). ']
["Ny DMCA dia mitaky ny fampandrenesanao ny voalaza ho fanitsakitsahana ny zon'ny mpamorona ahitana ireto fampahalalana manaraka ireto: (1) famaritana ny asa voaaro zon'ny mpamorona izay voalaza fa voahitsakitsaka; (2) famaritana ny votoaty voalaza fa manitsakitsaka sy fampahalalana ampy ahafahantsika mahita ny votoatiny; (3) fampahalalana momba anao, anisan'izany ny adiresinao, nomeraon-telefaona ary adiresy mailaka; (4) fanambarana avy aminao fa mino tsara ianao fa ny votoaty amin'ny fomba nitarainana dia tsy nomen'ny tompon'ny zon'ny mpamorona alalana, na ny mpandraharahany, na amin'ny asan'ny lalàna rehetra; "]
["(5) fanambarana nosoniavinao, eo ambany sazin'ny fianianana diso, fa marina ny vaovao ao amin'ny fampahafantarana ary manana fahefana hampihatra ny zon'ny mpamorona izay voalaza fa voahitsakitsaka ianao; "]
["Mety hiteraka fahatarana amin'ny fikarakarana ny fitarainanao ny tsy fampidirana ireo vaovao rehetra voalaza etsy ambony."]
['Fifandraisana']
['Alefaso mailaka izahay raha misy fanontaniana / sosokevitra.']
What is pathophysiology of lung cancer?
The pathophysiology of lung cancer refers to the changes in the normal physiological processes and mechanisms that occur in the development and progression of lung cancer.
Lung cancer is a complex disease that arises from the uncontrolled growth and division of abnormal cells in the lungs.
These cells can form tumors and spread to other parts of the body, leading to various symptoms and complications.
The pathophysiology of lung cancer involves several factors, including genetic mutations, environmental factors, and lifestyle choices.
Genetic mutations can occur in the DNA of lung cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can be caused by exposure to carcinogens, such as tobacco smoke, radon, asbestos, and air pollution.
Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is further divided into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.
The pathophysiology of these types of lung cancer can differ, as they have different genetic mutations and respond differently to treatment.
The pathophysiology of lung cancer also involves the interaction between cancer cells and the surrounding tissue, including the immune system.
Cancer cells can evade the immune system, allowing them to grow and spread unchecked.
Additionally, the tumor microenvironment can promote tumor growth and metastasis by providing a supportive environment for cancer cells.
The pathophysiology of lung cancer is a complex and dynamic process, and researchers are continuously working to better understand the underlying mechanisms to develop more effective treatments and improve patient outcomes.
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['Manodidina ny']
['Mampiasa solosaina mandeha ho azy (algoritma fianarana milina) ny BioMedLib mba hamoronana fanontaniana sy valiny.']
["Manomboka amin'ny famoahana biomedika 35 tapitrisa ao amin'ny PubMed/Medline izahay. ary koa ny pejin'ny tranonkala RefinedWeb."]
