Pathophysiology of colon cancer waxaa loola jeedaa hababka hoose iyo geedi socodka keena horumarinta iyo horumarka kansarka mindhicirka.
Kansarka mindhicirka weyn, oo sidoo kale loo yaqaano kansarka mindhicirka weyn, waa nooc kansar ah oo ka bilaabma mindhicirka weyn ama mindhicirka weyn, oo ah qaybo ka mid ah mindhicirka weyn.
Waxay sida caadiga ah ku bilaabataa koritaan la yiraahdo polyp, kaas oo waqti ka dib u noqon kara kansarka.
Pathophysiology-ka kansarka mindhicirka waxaa ku jira dhowr arrimood, oo ay ku jiraan isbeddellada hiddo-wadaha, caabuqa, iyo arrimaha deegaanka.
Isbedelada hiddo-wadaha waxay ku dhici karaan DNA-da unugyada mindhicirka, taasoo keenta koritaanka unugyada iyo kala qaybsanaanta unugyada.
Kala duwanaanshahan waxaa la dhaxli karaa ama la heli karaa, waxayna saameyn ku yeelan karaan hiddo-wadaha kala duwan ee ku lug leh koritaanka unugyada, kala qaybsanaanta, iyo dayactirka.
Caabuqa mindhicirka, oo ay sababi karaan xaalado ay ka mid yihiin cudurka mindhicirka ee mindhicirka, ayaa sidoo kale kordhin kara halista kansarka mindhicirka.
Caabuqa joogtada ah wuxuu keeni karaa in la sii daayo kiimikooyin kor u qaada koritaanka unugyada iyo kala qaybsanaanta, taasoo laga yaabo inay keento kansarka.
Waxyaabaha deegaanka ka dhaca, sida cuntada, qaab nololeedka, iyo kiimikada qaarkood, ayaa sidoo kale gacan ka geysan kara horumarinta kansarka mindhicirka.
Tusaale ahaan, cunista hilibka cas iyo hilibka la warshadeeyay waxay la xiriirtaa khatarta sii kordheysa ee kansarka mindhicirka.
Waxyaabaha kale, sida buurnaanta, sigaar cabista, iyo dhaqdhaqaaq la'aanta jirka, ayaa sidoo kale kordhin kara halista.
Marka kansarka mindhicirka uu soo baxo, wuxuu mari karaa dhowr marxaladood, laga bilaabo kansarka marxaladda hore ee ku kooban mindhicirka ilaa marxaladaha horumarsan ee kansarku ku faafay qaybaha kale ee jirka.
Unugyada kansarka waxay ku dhici karaan unugyada iyo xubnaha u dhow, waxayna sidoo kale ku faafi karaan nidaamka lymphatic ama dhiigga meelaha fog, sida beerka ama sanbabada.
Ogaanshaha hore iyo daaweynta ayaa fure u ah hagaajinta natiijooyinka, maadaama kansarka mindhicirka uu inta badan daaweyn karo marka la ogaado marxaladaha hore.
Baaritaanka joogtada ah, sida colonoscopy, wuxuu kaa caawin karaa inaad ogaato kansarka mindhicirka marxaladdiisa ugu horreysa, marka ay tahay mid la daaweyn karo.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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Xiriirka
Fadlan noogu soo dir emayl su'aal kasta / soo jeedin.
What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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