Sa maladia de Alzheimer est una maladia neurodegenerativa progressiva chi tocat in manera printzipale su cherbeddu, causende pèrdida de memòria, declinu cognitivu e mudadas de cumportamentu.
Sa càusa pretzisa de sa maladia de Alzheimer non est acrarada de su totu, ma si pensat chi siat su resurtadu de una cumbinatzione de fatores genèticos, ambientales e istile de vida.
Carchi fatore chi podet contribuire a s'isvilupu de sa maladia de Alzheimer includet:
1. Genètica: Sunt istados identificados tzertos genes chi aumentant su riscu de isvilupare sa maladia de Alzheimer, in particulare su gene de s'apolipoproteina E (APOE).
2. Edade: su riscu de isvilupare sa maladia de Alzheimer creschet cun s'edade, cun sa majoria de sas persones diagnosticadas a pustis de sos 65 annos.
3. Istòria familiare: Aere una istòria familiare de maladia de Alzheimer podet crèschere su riscu de isvilupare sa cunditzione.
4. Feridas a su capu: Un'istòria de feridas a su capu, in particulare cussas chi batint a pèrdida de cussèntzia, podet crèschere su riscu de maladia de Alzheimer.
5. Fatoris de arriscu cardiovasculares: cunditziones comente a pressione arta, colesterolu artu e diabete podent crèschere su riscu de isvilupare sa maladia de Alzheimer.
6. Fatoris de istili de vida: Unu istile de vida sedentàriu, una dieta pòbera, e una mancàntzia de istimulatzione mentale podent crèschere su riscu de maladia de Alzheimer.
7. Inflamatzione: s'inflamatzione crònica in su cherbeddu podet contribuire a s'isvilupu de sa maladia de Alzheimer.
8. Stress ossidativu: Unu disaccordu intre sa produtzione de radicales lìberos e sa capatzidade de s'organismu de los disintossicare podet contribuire a s'isvilupu de sa maladia de Alzheimer.
9. Placas amiloides e grovos neurofibrillares: S'ammuntonamentu de placas amiloides e grovos neurofibrillares in su cherbeddu est unu sinnu de sa maladia de Alzheimer, ma su ruolu chi giogant in s'isvilupu de sa cunditzione non est cumpresu de su totu.
Est de importu a notare chi sa càusa de sa maladia de Alzheimer est cumplessa e de seguru interessat una cumbinatzione de custos fatores.
Sa chirca est in cursu pro cumprèndere mègius sos mecanismos sutastantes e isvilupare tratamentos eficatzes pro custa cunditzione devastadora.
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Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.
Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.
Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.
Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.
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What causes alzheimer?
Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.
The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.
Some of the factors that may contribute to the development of Alzheimer's disease include:
1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.
2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.
3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.
4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.
5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.
6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.
7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.
8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.
9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.
It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.
Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.
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