What is pathophysiology of Colon cancer?

['Iscurtade custa pàgina']

Cale est sa fisiopatologia de su tumore a su colon?

Sa fisiopatologia de su tumore de su colon si riferit a sos mecanismos e protzessos sutastantes chi batint a s'isvilupu e sa progressione de su tumore de su colon.

Su tumore de su colon, connotu fintzas comente a tumore colorectale, est unu tipu de tumore chi cumintzat in su colon o in su rettu, chi sunt partes de s'intestine grussu.

A su sòlitu cumintzat comente una crèschida narada pòlipu, chi si podet isvilupare in crancu in su tempus.

Sa fisiopatologia de su tumore de su colon interessat diversos fatores, intre sos cales mutatziones genèticas, infiammamentu e fatores ambientales.

Sas mutatziones genèticas podent acontèssere in su DNA de sas tzèllulas de su colon, giughende a una crèschida e divisione tzellulare non controllada.

Custas mutatziones podent èssere ereditàrias o achiridas, e podent influire subra vàrios genes interessados in sa crèschida, divisione e riparazione tzellulare.

S' inframmatzione in su colon, chi podet èssere causada dae cunditziones comente sa maladia inflamatòria de s' intestin, podet fintzas crèschere su riscu de tumore a su colon.

S'inflamatzione crònica podet batire a sa liberatzione de sustàntzias chìmicas chi promovent sa crèschida e sa divisione tzellulare, batende in manera potentziale a s'isvilupu de su tumore.

Fatoris ambientalis, cummenti sa dieta, su stili de vida, e s'espositzioni a tzertas sustantzias chìmicas, podint puru contribuiri a s'isvilupu de su cancru de su colon.

Una dieta rica de carni rujas e elaboradas, pro nàrrere, est istada acapiada a un'arriscu prus mannu de tumore a su colon.

Àteros fatores, comente s'obesidade, su fumu e sa farta de atividade fìsica, podent fintzas aumentare su riscu.

Una borta chi su tumore de su colon s'isvilupat, podet progressare pro diversas fases, dae su tumore in fase primidia chi est cunfinadu a su colon a fases prus avantzadas ue su tumore s'est ispartu a àteras partes de su corpus.

Sas tzèllulas tumorales podent invadire sos tessidos e òrganos a curtzu, e si podent fintzas ispainare pro mèdiu de su sistema limfàticu o de su flussu sanguignu a logos a tesu, comente su fìgadu o sos purmones.

Su tratamentu pro su tumore a su colon includet una cumbinatzione de operatzione, chemioterapia e radioterapia, cunforma a s'istàdiu e a sa positzione de su tumore.

Sa rilevada primidia e su tratamentu sunt fundamentales pro megiorare sos resurtados, ca su tumore a su colon est a s'ispissu curàbile cando si pigat in sas fases primidias.

Sa proa regulare, comente sa colonoscopia, podet agiudare a rilevare su tumore a su colon in sos primos istàdios, cando est prus curàbile.

['Referèntzias']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.

Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.

Chen JK, Yaffe MB: Atlas Drugged. Cell. 2019, 177 (4): 803-805.

Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.

Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.

Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.

Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.

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What is pathophysiology of colon cancer?

The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.

Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.

It typically starts as a growth called a polyp, which can develop into cancer over time.

The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.

Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.

These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.

Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.

Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.

Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.

A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.

Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.

Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.

The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.

Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.

Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.

Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.

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