What is pathophysiology of Breast cancer?

Awa eqqal patophysiology n cancer n etari

Pathophysiology n breast cancer eqqal amutti n abnormal daɣ physiological processes d mechanisms illanen daɣ efes d efes n breast cancer

Ehay teɣare n biological d molecular mechanisms wi s itawan efes war n ila alxakum d asiflay n cancer tan daɣ tissue n etari

Awen ahan genetic, epigenetic d haratan n ahinzazaɣ wi ahanen daɣ efes, asiwad d efes n cancer n etari

Iyad n imutiyan n patofisiology daɣ cancer n etari ahan:

1. Genetic mutations: Mutations daɣ gene tan iyyad chund BRCA1 d BRCA2 addoben ad issiwaden azruf n asiwad n cancer n etari

Imuttiyan win addoben ad aqqilan n etari meɣ ad awidan daɣ azzaman n awadim

2. Hormonal imbalances: Hormones, hullan estrogen, addoben ad ilan edag daɣ efes d efes n cancer n etari

Awen war n oɣed daɣ hormon tan meɣ asiwad n estrogen ajjotnen addobat ad issiwid aharoj n cancer n etari

3. Inflammation: Inflammation tan ajjotnen daɣ tissue tan n etari addoben ad aruwan efes n cancer n etari s asiwad n efes d tamudre n cancer tan

4. Tumor microenvironment: Amizdaɣ wa ehan tumor, ahan extracellular matrix, immune cells d vases tan n idammen addoben ad aqqilan assahat fal efes d efes n cancer tan n etari

5. Metastasis: Cancer tan n etari addoben ad azun s ichrutan iyyad n taɣissa s sistem wan lymphatic meɣ bloodstream, eway id efes n secondary tumors daɣ organ tan n ajjama

Afahəm ən pathophysiologie ən kansar ən tayəte eqal aśohen fal igi ən assəməsədu atiwasan, afanaz ən azzaman əd tikarsiwen ən asafar.

['Isalan wi illanen']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Underwood SM: Breast cancer in African American women: nursing essentials. ABNF J. , 17 (1): 3-14.

Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.

Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.

Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.

Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.

Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.

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['Dǎɣ asikin, neural net wa iknanen tirmawen ən assestan, eqal aśohen aśohat dǎɣ alwaq wa id itawan dǎɣ maɗin ən maɗinan. sund, iddikud ən adinat wi atiwasananen as aśohat atiwasanan.']

['Harkuk arha majrad n doctor inek meɣ n awadim n assexat n tazmert n addinat fal aśahat n aśahat. War t-id-t-igdel majrad n aśahat n awadim meɣ azzaman daɣ aśahat fal as harat awa iktabem fal site wen. Afal as ad t-illa aśahat n aśahat n aśahat, asiwel 911 meɣ aru s ehan n aśahat n aśahat wa oharnen daɣ azzaman. War t-illa majrad n aśahat n awadim d aśahat fal site wen meɣ axadam net. BioMedLib meɣ inaxdiman net meɣ awadim wa iknanen fal site wen, war t-illa majrad, iknan meɣ iknan, fal isalan wi dawanen meɣ axadam net']

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['A fal tazamt s tiditt as isalan meɣ isuj win illanen daɣ asuj n asuj net meɣ alxidmaten iknan alxaq inek n alxaq, addobat ad aɣ-d-tazneḍ (meɣ agent inek) isalan meɣ isuj win ad n-ikkes meɣ ad n-isikkid alxidmat']

['Isalan ilzam ad ittusiknan s eɣaf s email (ikayad edag "Contact" i tansa n email)']

['DMCA t-assirɣas as isalan inek n asiwad n alxaq n alxoriya eha isalan win: (1) almaɣna n alxidmat eha alxaq n alxoriya eqqal harat n asiwad eha alxaq n alxoriya; (2) almaɣna n almaɣna eha alxoriya d isalan ajjotnen ijjan aɣ ad n afhaman almaɣna; (3) isalan n alɣisab inek, ahan tansa, amaṭṭaf n tilifun d tansa n email inek; (4) almaɣna inek n as ilan tumast n alxaq n alxoriya as almaɣna wa s eha alxaq eha alxaq eha alxaq war eha alxaq n alxaq eha alxoriya meɣ amatikki net meɣ s alxidmat n achareɣa fuk']

['(5) almaɣna n awen, iktab daɣ azruf n alkad n tiditt, as isalan win isalan aqqalan tiditt tolas ilan tanaya n as artay alxaqqan win alxakum wi s allaɣen as ikna']

['Dǎɣ awa, əmik ən əmik ən alxaq meɣ awadim ən alxaq ən alxaq meɣ awadim atiwafan ye igi ən alxaq ən alxaq.']

['A fal war t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id-t-id']

['Assahat']

['Ilzam aɣ e-mail s asteqsi meɣ asukni']

What is pathophysiology of breast cancer?

Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.

It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.

This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.

Some of the key pathophysiological changes in breast cancer include:

1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.

These mutations can be inherited or acquired during a person's lifetime.

2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.

An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.

3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.

4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.

5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.

Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.

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