What is pathophysiology of Prostate cancer?

['Tie saa kratafa yi']

Dɛn ne ahobae kotoku mu kokoram yare?

Sɛ wɔka sɛ obi anya kokoram a, nea ɛkyerɛ ne sɛnea yare no kɔ so.

Sɛ obi nya kokoram a, efi ne honam akwaa a ɛwɔ ne dwensɔtwaa ase no mu.

Sɛ ɔbarima nya nna ho akɔnnɔ a, ɛma onya ahoɔfɛ.

Wɔante nea ɛma obi nya kokoram no ase yiye, nanso wonim nneɛma pii a ɛma obi nya kokoram.

Eyinom bi ne mfe, abusua a obi fi mu, abusua a ofi mu, ne awosu mu nsakrae ahorow bi.

Mmarima a wɔn mfe akɔ anim na wonya ahoɔmmerɛw mu kokoram, na wɔn a wonya no dodow no ara yɛ mmarima a wɔadi boro mfe 65.

Bio nso, mmarima a wɔn abusuafo anya kokoram no, wɔn nso, wɔn ho betumi ayɛ den paa.

Nea ɛma obi nya dwensɔtwaa mu kokoram ne sɛ, nkwammoaa a ɛwɔ dwensɔtwaa mu no nyin kyekyɛ na wɔntumi nni so.

Nea ɛma eyi tumi si ne sɛ, awosu mu nsakrae a ɛma obi nya ahoɔden pii ma otumi nyin yiye no ma otumi nya ahoɔden kakra.

Saa nsakrae yi betumi ama nkwammoaa no anyin a wɔrentumi nyɛ ho hwee, na ama wɔawo kokoram.

Bere a kokoram no nyin no, etumi kɔ ntini ne akwaa a ɛbɛn hɔ mu te sɛ dwensɔ, kotoku, ne ntini mu ntini a ɛbɛn hɔ.

Wɔ tebea ahorow bi mu no, kokoram nkwammoaa no betumi atetew afi kokoram no ho na atrɛw akɔ nipadua no afã foforo denam mogya anaa mogya mu ntini a ɛma mogya no fa ntini no mu so, adeyɛ a wɔfrɛ no metastasis.

Sɛ kokoram no trɛw a, ebetumi ayɛ den sɛ wɔbɛsa.

Sɛ obi nya ahoɔmmerɛw a, nneɛma bi te sɛ testosterone nso ka ho.

Testosterone betumi ama ahobae kotoku mu kokoram nkwammoaa anyin, na atirimpɔw a ɛwɔ ahobae kotoku mu kokoram ho ayaresa pii mu ne sɛ ɛbɛtew saa nkwammoaa yi dodow so anaasɛ ebesiw ne nkɛntɛnso ano.

Ne tiaatwa mu no, nea ɛma obi nya dwensɔtwaa mu kokoram ne sɛ, nkwammoaa a ɛwɔ dwensɔtwaa mu no nyin kyekyɛ na wɔntumi nni so.

Sɛ obi betumi anya aduru a ɛbɛboa no na watumi ahwɛ ne yare no yiye a, ehia sɛ ohu ɔkwan a ɔfa so nya yare no.

['Nsɛm a Wɔakyerɛw']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Zobniw CM, Causebrook A, Fong MK: Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer. Res Rep Urol. 2014, 6 (): 97-105.

Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.

Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.

Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.

Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.

Kotani K, Sekine Y, Ishikawa S, Ikpot IZ, Suzuki K, Remaley AT: High-density lipoprotein and prostate cancer: an overview. J Epidemiol. 2013, 23 (5): 313-9.

Jadvar H: Molecular imaging of prostate cancer: a concise synopsis. Mol Imaging. , 8 (2): 56-64.

['Nsɛm a Ɛnsɛ sɛ Wɔka:']

['Wɔayɛ wɛbsaet yi sɛ wɔmfa nkyerɛkyerɛ na wɔmfa nkyerɛkyerɛ afoforo, na ɛnyɛ sɛ wɔde rema aduruyɛ ho afotu anaa wɔde rema adwuma.']

['Ɛnsɛ sɛ wɔde nsɛm a wɔde ama no di dwuma de hwehwɛ yare bi ho yare anaa wɔde sa yare, na ɛsɛ sɛ wɔn a wɔrehwehwɛ ayaresa ho afotu no kohu oduruyɛfo a ɔwɔ tumi krataa.']

['Yɛsrɛ wo hyɛ no nsow sɛ, sɛnea wɔhwɛ nsɛmmisa no so no, sɛ ɛba sɛ wɔrekyerɛw nnipa dodow a wɔanya yare bi ho asɛm a, ɛntaa nsi yiye.']

['Hwehwɛ afotu fi wo duruyɛfo anaa ɔyaresafo foforo a ɔfata hɔ bere biara wɔ yare bi ho. Nnya adwene sɛ wo nsa bɛka oduruyɛfo afotu anaasɛ wubetwa so esiane biribi a woakenkan wɔ wɛbsaet yi so nti. Sɛ wususuw sɛ ebia wo ho behia wo wɔ ayaresa mu a, frɛ 911 anaa kɔ ayaresabea a ɛbɛn wo paa ntɛm ara.']

['Nsɛm a wɔmmɔ ho ban:']

['Digital Millennium Copyright Act a wɔhyɛe wɔ afe 1998 mu, 17 U.S.C. § 512 (DMCA) no ma wɔn a wɔwɔ hokwan sɛ wɔyɛ wɔn nneɛma no kwan sɛ wɔyɛ nea wɔpɛ biara.']

["Sɛ wugye di sɛ nsɛm anaa nneɛma a ɛwɔ yɛn wɛbsaet anaa yɛn dwumadibea no mu bi to wo mmara a wode bɔɔ nneɛma ho ban no a, wo (anaa w'ananmusifo) betumi de krataa akɔma yɛn de aka sɛ yɛnyi nsɛm anaa nneɛma no, anaa yɛmmɔ kwan mma wonnya bi."]

["Ɛsɛ sɛ wɔde krataa ne email na ɛbɔ amanneɛ (hwɛ 'Contact' afã hɔ na wubehu email address)."]

['DMCA hwehwɛ sɛ wo amanneɛbɔ a ɛfa nea wɔkyerɛ sɛ ɛyɛ mmara a wobu so ho no de nsɛm a edidi so yi ka ho: (1) adwuma a mmara bɔ ho ban a wɔkyerɛ sɛ wɔadi so no ho asɛm; (2) nsɛm a wɔkyerɛ sɛ wɔadi so no ho asɛm ne nsɛm a ɛbɛboa yɛn ma yɛahu baabi a ɛwɔ; (3) wo ho nsɛm a yɛde bedi nkitaho, a wo address, telefon nɔma ne email address ka ho; (4) wo nsɛm a ɛkyerɛ sɛ wugye di sɛ nea wɔabɔ ho sobo no nyɛ nea mmara ma ho kwan; ']

['(5) wo nsahyɛ a ɛkyerɛ sɛ nsɛm a ɛwɔ amanneɛbɔ no mu yɛ nokware, na wowɔ tumi sɛ wode nea wɔkyerɛ sɛ woadi ho dwuma no bedi dwuma; ']

['ne (6) nea ɔwɔ tumi sɛ ɔyɛ biribi ma obi a ɔwɔ tumi sɛ ɔyɛ biribi ma no no nsaano nkyerɛwee.']

['Sɛ woamfa nsɛm a yɛaka yi nyinaa anka ho a, ebetumi ama wo ka no akyɛ.']

['Nkitahodi']

['Yɛsrɛ wo, fa nsɛmmisa anaa nyansahyɛ biara a wowɔ brɛ yɛn wɔ e-mail so.']

What is pathophysiology of prostate cancer?

The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.

Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.

The prostate gland produces seminal fluid, which nourishes and transports sperm.

The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.

These include age, family history, race, and certain genetic mutations.

Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.

Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.

The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.

This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.

These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.

As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.

In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.

Once the cancer has spread, it can be more difficult to treat.

Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.

Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.

In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.

Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.

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