Prostata saratonining patofiziologiyasi kasallikning rivojlanishiga va rivojlanishiga olib keladigan asosiy mexanizmlar va jarayonlarni anglatadi.
Prostata saratoni - bu erkaklarda siydik suyaklari ostida joylashgan kichik, yong'oq shaklidagi organ bo'lgan prostata bezining hujayralaridan paydo bo'ladigan zararli o'smadir.
Prostata bezi seminal suyuqlikni ishlab chiqaradi, u spermatozoidlarni oziqlantiradi va olib boradi.
Prostat saratonining aniq sababi to'liq aniqlanmagan, ammo bu kasallikka chalinish xavfini ko'paytiradigan bir nechta omillar ma'lum.
Bunga yosh, oilaviy tarix, irq va ba'zi genetik mutatsiyalar kiradi.
Prostat saratoni ko'proq keksa erkaklarda uchraydi, aksariyat holatlar 65 yoshdan oshgan erkaklarda uchraydi.
Bundan tashqari, oilaviy tarixda prostata saratoni bo'lgan erkaklar, afro-amerikalik erkaklar va Karib dengizi kelib chiqishi bo'lgan erkaklar ko'proq xavf ostida.
Prostata saratonining patofiziologiyasi prostata bezi ichidagi hujayralarning nazoratsiz o'sishi va bo'linishini o'z ichiga oladi.
Bu ba'zi o'sish omillarining haddan tashqari ko'rsatilishiga yoki o'smani bostiruvchi genlarning inaktivatsiyasiga olib keladigan genetik mutatsiyalar tufayli sodir bo'lishi mumkin.
Ushbu mutatsiyalar hujayralarning tartibga solinmagan o'sishiga olib kelishi mumkin, bu esa o'simlik hosil bo'lishiga olib keladi.
O'simlik o'sishi bilan u yaqin atrofdagi to'qimalar va organlarga, masalan, siydik suyaklari, to'g'ri ichak va yaqin atrofdagi limfa tugunlariga hujum qilishi mumkin.
Ba'zi hollarda saraton hujayralari birlamchi o'smadan ajralib chiqib, qon oqimi yoki limfa tizimi orqali tananing boshqa qismlariga tarqalishi mumkin, bu jarayon metastaz deb nomlanadi.
Saraton tarqalganidan so'ng, uni davolash qiyinroq bo'lishi mumkin.
Prostat saratoni, shuningdek, gormon omillar, ayniqsa androgen gormon testosteron ta'sirida bo'lishi mumkin.
Testosteron prostata saratoni hujayralarining o'sishini rag'batlantirishi mumkin va prostata saratoni uchun ko'plab davolash usullari ushbu gormon darajasini kamaytirishga yoki uning ta'sirini to'xtatishga qaratilgan.
Xulosa qilib aytganda, prostata saratonining patofiziologiyasi prostata bezi ichidagi hujayralarning nazoratsiz o'sishi va bo'linishini o'z ichiga oladi, bunga genetik, hormonal va atrof-muhit omillari ta'sir qilishi mumkin.
Kasallikning asosiy mexanizmlarini tushunish samarali davolanish usullarini ishlab chiqish va prostata saratoni bemorlari uchun natijalarni yaxshilash uchun juda muhimdir.
Zobniw CM, Causebrook A, Fong MK: Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer. Res Rep Urol. 2014, 6 (): 97-105.
Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.
Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.
Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.
Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.
Kotani K, Sekine Y, Ishikawa S, Ikpot IZ, Suzuki K, Remaley AT: High-density lipoprotein and prostate cancer: an overview. J Epidemiol. 2013, 23 (5): 313-9.
Jadvar H: Molecular imaging of prostate cancer: a concise synopsis. Mol Imaging. , 8 (2): 56-64.
Mas'uliyatdan voz kechish: tibbiy
Ushbu veb-sayt faqat ta'lim va axborot maqsadlari uchun mo'ljallangan bo'lib, tibbiy maslahat yoki professional xizmatlar ko'rsatmaydi.
Ma'lumotlardan sog'liqni saqlash muammolari yoki kasalliklarni tashxislash yoki davolash uchun foydalanmaslik kerak va shaxsiy tibbiy maslahat so'raganlar litsenziyaga ega bo'lgan shifokor bilan maslahatlashishlari kerak.
Iltimos, savollarga javoblarni ishlab chiqaradigan neyron tarmog'i, ayniqsa, raqamli tarkibga kelganda noto'g'ri ekanligiga e'tibor bering. Masalan, ma'lum bir kasallik bilan kasallangan odamlar soni.
Har doim shifokoringiz yoki boshqa malakali sog'liqni saqlash provayderining maslahatini so'rang. Hech qachon professional tibbiy maslahatni e'tiborsiz qoldirmang yoki ushbu veb-saytda o'qiganingiz sababli uni so'rashni kechiktirmang. Agar siz tibbiy favqulodda vaziyatga duchor bo'lishingiz mumkin deb o'ylasangiz, darhol 911 ga qo'ng'iroq qiling yoki eng yaqin favqulodda vaziyatlar bo'limiga boring. Ushbu veb-sayt yoki uning ishlatilishi bilan hech qanday shifokor- bemor munosabatlari yaratilmaydi. BioMedLib ham, uning xodimlari ham, ushbu veb-saytga hech qanday hissa qo'shuvchi, bu erda taqdim etilgan ma'lumot yoki uning ishlatilishi bilan bog'liq hech qanday bayonot bermaydi.
Mas'uliyatdan voz kechish: mualliflik huquqi
1998-yilgi raqamli ming yillik mualliflik huquqi to'g'risidagi qonun, 17 U.S.C. 512-moddasi (DMCA) Internetda paydo bo'lgan materiallar AQSh mualliflik huquqi to'g'risidagi qonun bo'yicha o'z huquqlarini buzadi deb hisoblaydigan mualliflik huquqi egalari uchun choralar ko'rsatadi.
Agar siz bizning veb-saytimiz yoki xizmatlarimiz bilan bog'liq bo'lgan har qanday tarkib yoki material sizning mualliflik huquqingizni buzadi deb yaxshi ishonchga ega bo'lsangiz, siz (yoki sizning vakilingiz) bizga tarkib yoki materialni olib tashlashni yoki unga kirishni to'xtatishni so'rab xabar yuborishingiz mumkin.
Xabarlar yozma ravishda elektron pochta orqali yuborilishi kerak (elektron pochta manzili uchun "Muloqot" bo'limiga qarang).
DMCA sizning da'vo qilingan mualliflik huquqi buzilganligi to'g'risidagi xabarnomangizda quyidagi ma'lumotlarni o'z ichiga olishini talab qiladi: (1) da'vo qilingan mualliflik huquqi buzilgan asarning tavsifi; (2) da'vo qilingan mualliflik huquqi buzilgan tarkibning tavsifi va bizga tarkibni topishga imkon beradigan etarli ma'lumotlar; (3) siz uchun aloqa ma'lumotlari, shu jumladan sizning manzilingiz, telefon raqami va elektron pochta manzili; (4) siz tomonidan da'vo qilingan tarzda tarkib mualliflik huquqi egasi yoki uning vakili yoki har qanday qonun tomonidan ruxsat berilmaganligiga ishonchingiz borligi to'g'risidagi bayonot;
(5) siz tomonidan yolg'on guvohlik berish jazosi ostida imzolangan, bildirishnomadagi ma'lumotlar to'g'ri ekanligi va siz buzilgan deb da'vo qilingan mualliflik huquqlarini amalga oshirish vakolatiga ega ekanligingiz to'g'risidagi bayonot;
va (6) mualliflik huquqi egasining yoki mualliflik huquqi egasi nomidan harakat qilishga vakolatli shaxsning jismoniy yoki elektron imzosi.
Yuqoridagi barcha ma'lumotlarni kiritmaslik sizning shikoyatingizni ko'rib chiqishni kechiktirishi mumkin.
Aloqa qilish
Iltimos, har qanday savol / taklif bilan bizga elektron pochta xabarini yuboring.
What is pathophysiology of prostate cancer?
The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.
Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.
The prostate gland produces seminal fluid, which nourishes and transports sperm.
The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.
These include age, family history, race, and certain genetic mutations.
Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.
Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.
The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.
This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.
These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.
As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.
In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.
Once the cancer has spread, it can be more difficult to treat.
Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.
Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.
In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.
Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.
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