What is pathophysiology of Diabetes?

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Che cos'è a fisiopatologia del diabete?

Ła patofisiologia del diabete se riferise al studio dei processi fisiologici disordinà che porta al sviłupo del diabete mellito.

El diabete mellito xe un grupo de malatie metaboliche caraterixà da alti livełi de zucaro nel sangue (glucosio) che vien fora da difeti neła secrezion de insulina, ne l' asion de l' insulina o in tuti e do.

Ła patofisiologia del diabete ła coinvolge ła conplesa interasion de fatori genetici, ambientałi e del stiłe de vita che contribuise al sviłupo deła małatia.

Nel diabete de tipo 1, ła patofisiologia ła coinvolge na destrusion autoimune dełe celule beta che produxe insulina nel pancreas, portando a na deficensa neła produsion de insulina.

Questo porta a 'na incapacità de regołar i livełi de glucosio nel sangue, portando a iperglicemia (zucaro alto nel sangue).

Nel diabete de tipo 2, a fisiopatologia xe pì conplesa e coinvolge sia a rexistensa a l'insulina che a secrezion de insulina indebołìa.

Ła rexistensa a l'insulina ła se verifica quando łe celule del corpo no łe risponde come che se deve a l'insulina, portando a l'incapacità de usar efetivamente el glucosio par l'energia.

Questo fa sì che el pancreas produca pì insulina pa' provar a superare a rexistensa, ma col tempo el pancreas podaria no essar bon de starghe drio ała domanda, portando a na diminuzion neła produsion de insulina.

El diabete gestaxionale, che se verifica durante a gravidansa, xe causà da canbiamenti ormonali che porta a rexistensa a l'insulina.

Ła placenta produxe ormoni che pol blocar l' asion de l' insulina, portando a un aumento dei livełi de glucosio nel sangue.

Ła patofisiologia del diabete ła coinvolge anca el sviłupo de conplicasion, come dani ai vasi sanguigni, nervi e organi, che i pol portar a gravi problemi de salute come małatia cardiaca, ictus, małatia renałe e perdita de vista.

Capìr a patofisiologia del diabete xe fondamentałe pa sviłupar terapie e strategie de prevension efficaci pa sta malatia cronica.

['Riferimenti']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.

Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.

Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.

Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.

Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.

Palicka V: Pathophysiology of Diabetes Mellitus. EJIFCC. 2002, 13 (5): 140-144.

Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.

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What is pathophysiology of diabetes?

Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.

Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.

The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.

In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.

This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).

In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.

Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.

This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.

Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.

The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.

The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.

Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.

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