What is pathophysiology of Colon cancer?

['Pamati hini nga pahina']

Ano an pathophysiology han colon cancer?

An pathophysiology han colon cancer in natudlok ha mga mekanismo ngan proseso nga nagigin hinungdan han pagtikang ngan pag-uswag han colon cancer.

An colon cancer, kilalado liwat nga colorectal cancer, usa nga klase hin kanser nga natikang ha colon o rectum, nga bahin han dako nga tinai.

Kasagaran nga nagtitikang ito sugad nga pagtubo nga gintatawag nga polyp, nga mahimo magin kanser paglabay han panahon.

An pathophysiology han colon cancer in nag-uupod hin pipira nga mga hinungdan, upod na an genetic mutations, inflammation, ngan environmental factors.

An genetic mutations in nahihimo ha DNA han colon cells, nga nagriresulta ha diri kontrolado nga pagtubo ngan pagbahin han selula.

Ini nga mga mutation mahimo mapanunod o makuha, ngan mahimo ito makaapekto ha magkalainlain nga gene nga may kalabotan ha pagtubo, pagbahin, ngan pag-ayad han selyula.

An inflammation ha colon, nga mahimo magin hinungdan han inflammatory bowel disease, mahimo liwat makahatag hin peligro nga magkaada colon cancer.

An maiha nga paghubag mahimo magresulta ha paggawas hin mga kemikal nga nag-aaghat han pagtubo ngan pagbarahin han selyula, nga posible magresulta hin kanser.

An mga hinungdan ha palibot, sugad han pagkaon, estilo han pagkinabuhi, ngan pagkaada hin pipira nga kemikal, mahimo liwat makaaghat hin kanser ha colon.

Pananglitan, an pagkaon nga damu an pula ngan ginproseso nga karne, may kalabotan ha daku nga posibilidad nga magkaada kanser ha colon.

An iba nga mga hinungdan, sugad han sobra nga katambok, pagsigarilyo, ngan kawaray ehersisyo, mahimo liwat makabulig ha pagpahitaas han peligro.

Kon magkaada na hin colon cancer, mahimo ini mag-uswag ha iba-iba nga kahimtang, tikang ha temprano nga kahimtang nga an kanser aada la ha colon tubtob ha mas grabe nga kahimtang diin an kanser nagsarang ha iba nga bahin han lawas.

An mga selyula han kanser mahimo makaapekto ha mga tisyu ngan organo nga hirani ha iya, ngan mahimo liwat magpasarang ha lymphatic system o ha dugo ngadto ha hirayo nga mga lugar, sugad han atay o baga.

An pagtambal ha colon cancer kasagaran nga nagkombinar hin operasyon, chemotherapy, ngan radiation therapy, depende ha stage ngan lokasyon han kanser.

An sayo nga pag-eksamin ngan pagtambal importante ha pagpauswag han resulta, tungod kay an colon cancer agsob nga natatambal kon madiskobrehan ha temprano nga mga hugna.

An regular nga pag-eksamin, sugad han colonoscopy, makakabulig ha pag-eksamin han kanser ha colon ha temprano nga mga yugto hito, kon masayon na ito matambal.

['Mga reperensya']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.

Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.

Chen JK, Yaffe MB: Atlas Drugged. Cell. 2019, 177 (4): 803-805.

Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.

Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.

Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.

Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.

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What is pathophysiology of colon cancer?

The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.

Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.

It typically starts as a growth called a polyp, which can develop into cancer over time.

The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.

Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.

These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.

Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.

Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.

Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.

A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.

Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.

Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.

The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.

Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.

Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.

Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.

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