Jàngoroy kanamu ndey ji dafay tekki ay coppite yu doy waar ci doxalin ak doxaliinu yaram yi am ci juddu ak yokkute gu kanamu ndey ji.
Bokk na ci gëstu yiy tax ba doomu-aadama yi ak doomu-aadama yi am jàngoroy màndargam dënn yi di màgg te di law ci biir dënn yi.
Lii nag, ci la bokk ci gene yi, epigenetics yi ak li wër àddina si, di tax ba jàngoroy borom bi di tàmbalee am, di yokku, di yokku.
Yenn ci coppite yu am solo ci pathophysiology bu jàngoroy borom bi:
1. Yëngu-yënguy gene yi: Yëngu-yënguy gene yi, niki BRCA1 ak BRCA2, mën na yokk jafe-jafey am jàngoroy ndey ji.
Yëngu-yënguy yaram yooyu mën nañu leen a donn walla ñu jële leen ci dundug nit ki.
2. Jàppum hormones yi: Hormones yi, rawatina estrogen, mën nañ a indi jàngoroy kansar ci dënn bi.
Jëfandikoo hormones yi ci yaram walla lu ëpp ci estrogen mën na yokk feebar bi.
3. tàggat: tàggat bu yàgg bu am ci dënn bi mën na indi jàngoroy kansar ci dënn bi ndax dafay tax ay selilëer yuy law di gën a màgg.
4. Mbëjfeppalug sëq bi: Mbëjfeppalug sëq bi, mu ngi ëmb ay cell yuy génne ci biir yaram wi, ay cell yuy aar yaram wi, ak ay deret yuy dugg ci deret ji, loolu lépp mën na indi màggug sëq bi ak lawug ko.
5. Metastase: Kanser bi mën na law ba ci yeneen céri yaram jaare ko ci deret ji, ba tax ay jàngoroy sëq di am ci yeneen céri yaram yi sore.
Xam-xamu jëmm ji ñu def ci jàngoroy kansar ci dënn dafa am solo lool ngir mën a xam lu ko waral, xam ko ci njëlbeen, ak feebar bi.
Underwood SM: Breast cancer in African American women: nursing essentials. ABNF J. , 17 (1): 3-14.
Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.
Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
['Waxtaan: wér-gu-yaram']
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['Xam-xam bi ñu leen di jox waruñu koo jëfandikoo ngir seet walla faj wér-gi-yaram walla jàngoro, te ñi bëgg a laaj ay leeral ci wàllu wér-gi-yaram war nañu seeti doktoor bu ñu nangu.']
['Seetal ne jàmbaar gii di sàkk tontu yi ci laaj yi, dafa ñàkk solo lool ci lu jëm ci limu limu nit ñi, niki limub ñi ñu jàngal ab jàngoro.']
['Danga war a wutal sa doktoor walla beneen fajkat bu am xam-xam ci lu jëm ci wér-gu-yaram. Bul sàggane walla nga gaaw a wutal sa doktoor ndax dara lu nga jàng ci dal bii. Soo xalaatee ne am nga lu la soxla ci wér-gu-yaram, wool 911 walla nga dem ci fajukaay bu la gën a jege ci saa si. Dal bii walla jëfandikoo ko taxul nga nekk ak ab doktoor walla ab jarag. BioMedLib walla ay liggéeykatam, walla kenn ci ñi koy jëfandikoo, duñu wax dara, muy lu leer mbaa lu leeradi, ci lu jëm ci xibaar yi ñu leen di jox fii walla ci ni ñu koy jëfandikoo.']
['Séddo: sañ-sañu jëfandikoo']
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['Bind nañu ay yëgle ci mbind, ci ab bataaxal (Xoolal "Contact" ngir xam màkkaanu bataaxal bi).']
['DMCA dafa digle ne sa bataaxal bu jëm ci jàddug sañ-sañ bu ñu sos war na ëmb li ci topp: (1) xët wu jëm ci liggéey bi ñu sos ne jàdd nañ ko; (2) xët wu jëm ci li ñu sos ne jàdd nañ ko ak ay xibaar yu doy ngir may nu nu nu man a gis li mu ëmb; (3) ay xibaar yu jëm ci yaw, boole ci sa màkkaanu dal, sa limu telefóni ak sa màkkaanu imeel; (4) ab kàddu bu jóge ci yaw bu lay xamal ne am nga yaakaar bu wér ne li nga sos ci anam wi ñu la ko sosu, moom boroom sañ-sañ bi, walla ki ko dénk, walla benn yoon, nanguwu ko; ']
['(5) ab bataaxal bu ñu la jox, nga dëggal ci sa loxo ne li nga bind dëgg la te am nga sañ-sañu sàmm sañ-sañu jëfandikoo sañ-sañu bind bi ñu la sosal ne yàqu na;']
['ak (6) benn màndarga buy firndeel walla buy wone ay màndarga yuy wone ne moom la sañ-sañu jëfandikoo walla mu ngi koy jëfandikoo ci turu moom. ']
['Suñ la ci dugalul lépp lu ñu wax ci kaw, mën na tax ba say tawat di gaaw a jàppale.']
['Waxtaan']
['Yónneel nu ab imeel bu la laaj walla nga am ay xalaat.']
What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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['Lu jëm ci']
['BioMedLib dafay jëfandikoo ay ordinatëër yu automate (algoritmi jàngatukaay) ngir sos ay laaj-ak- tontu.']
['Nu tàmbali ci 35 milyoŋi téerey xam-xamu jëmm ci PubMed/Medline. Te itam ci xëti web yi ci RefinedWeb.']
