What causes Colon cancer?

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結腸癌是由什麼引起的?

結腸癌是由於結腸或直腸內異常細胞的不受控制的生長所引起.

結腸癌的確切原因尚不清楚,

這些措施包括:

1. 年齡:患結腸癌的風險隨著年齡增長而增加,

2. 病史:個人或家族有結腸癌或息肉病史,

某些遺傳性遺傳性疾病, 如家族性腺瘤性多囊性癌症 (FAP) 和遺傳性非多囊性結腸直腸癌 (HNPCC),

肥胖,吸煙及過度飲酒等因素, 都可能增加患結腸癌的風險.

腸道炎症:長期存在的腸道炎症,

糖尿病患者可能患上結腸癌.

其他癌症的放射治療可能增加患結腸癌的風險.

非洲裔美國人患結腸癌的風險高於其他種族.

必須注意的是,有了以上一個或多個危險因素,

定期檢查及及早發現有助於預防或早期發現結腸癌,

['其他資料']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

McWhirter JE, Todd LE, Hoffman-Goetz L: Beliefs about causes of colon cancer by English-as-a-Second-Language Chinese immigrant women to Canada. J Cancer Educ. 2011, 26 (4): 734-9.

Gamble JF: Asbestos and colon cancer: a weight-of-the-evidence review. Environ Health Perspect. 1994, 102 (12): 1038-50.

Ashish S, Raj M: Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden. Cureus. 2022, 14 (3): e22894.

Xu W, Zhang Y, Chen L, Qiu F, Zhang B, Wu L, Peng Z, Tang H: Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget. 2017, 8 (42): 71954-71964.

Wang J, Wu HF, Shen W, Xu DY, Ruan TY, Tao GQ, Lu PH: SRPK2 promotes the growth and migration of the colon cancer cells. Gene. 2016, 586 (1): 41-7.

Taketo MM, Edelmann W: Mouse models of colon cancer. Gastroenterology. 2009, 136 (3): 780-98.

Slattery ML, Kerber RA: The impact of family history of colon cancer on survival after diagnosis with colon cancer. Int J Epidemiol. 1995, 24 (5): 888-96.

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What causes colon cancer?

Colon cancer, also known as colorectal cancer, is caused by the uncontrolled growth of abnormal cells in the colon or rectum.

The exact cause of colon cancer is not known, but several factors can increase the risk of developing the disease.

These include:

1. Age: The risk of colon cancer increases with age, with most cases occurring in people over the age of 50.

2. Family history: A personal or family history of colon cancer or polyps increases the risk of developing the disease.

3. Inherited syndromes: Certain inherited genetic syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), can increase the risk of colon cancer.

4. Lifestyle factors: A diet high in red and processed meats, obesity, smoking, and excessive alcohol consumption can increase the risk of colon cancer.

5. Inflammatory bowel disease: Long-term inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, can increase the risk of colon cancer.

6. Type 2 diabetes: People with type 2 diabetes have an increased risk of developing colon cancer.

7. Radiation therapy: Radiation therapy for other cancers in the abdomen can increase the risk of colon cancer.

8. Race: African Americans have a higher risk of developing colon cancer than other races.

It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop colon cancer, and some people who develop colon cancer may not have any known risk factors.

Regular screening and early detection can help prevent colon cancer or detect it at an early stage when it is most treatable.

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