Die patofisiologie van longkanker verwys na die veranderinge in die normale fisiologiese prosesse en meganismes wat in die ontwikkeling en progressie van longkanker voorkom.
Longkanker is 'n komplekse siekte wat voortspruit uit die onbeheerde groei en verdeling van abnormale selle in die longe.
Hierdie selle kan gewasse vorm en na ander dele van die liggaam versprei, wat tot verskeie simptome en komplikasies lei.
Die patofisiologie van longkanker behels verskeie faktore, insluitend genetiese mutasies, omgewingsfaktore en lewenstylkeuses.
Genetiese mutasies kan in die DNA van longselle voorkom, wat lei tot onbeheerde selgroei en -verdeling.
Hierdie mutasies kan geërf of verkry word, en hulle kan veroorsaak word deur blootstelling aan kankerverwekkers, soos tabakrook, radon, asbes en lugbesoedeling.
Longkanker kan in twee hooftipes geklassifiseer word: kleinselle longkanker (SCLC) en nie-kleinselle longkanker (NSCLC). NSCLC word verder verdeel in drie subtipes: adenokarsinoom, skuimselkarcinoom en grootselkarcinoom.
Die patofisiologie van hierdie tipes longkanker kan verskil, aangesien hulle verskillende genetiese mutasies het en verskillend op behandeling reageer.
Die patofisiologie van longkanker behels ook die interaksie tussen kanker selle en die omliggende weefsel, insluitend die immuunstelsel.
Kanker selle kan die immuunstelsel ontduik, wat hulle in staat stel om onbeheerbaar te groei en te versprei.
Daarbenewens kan die tumormikro-omgewing tumorgroei en metastase bevorder deur 'n ondersteunende omgewing vir kanker selle te bied.
Die patofisiologie van longkanker is 'n komplekse en dinamiese proses, en navorsers werk voortdurend om die onderliggende meganismes beter te verstaan om meer effektiewe behandelings te ontwikkel en pasiënte se uitkomste te verbeter.
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Nurwidya F, Syahruddin E, Yunus F: Pain management in lung cancer. Adv Respir Med. 2016, 84 (6): 331-336.
Khan KA, Kennedy MP, Moore E, Crush L, Prendeville S, Maher MM, Burke L, Henry MT: Radiological characteristics, histological features and clinical outcomes of lung cancer patients with coexistent idiopathic pulmonary fibrosis. Lung. 2015, 193 (1): 71-7.
Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A: Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. Int J Mol Sci. 2022, 23 (21): .
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Mucchietto V, Crespi A, Fasoli F, Clementi F, Gotti C: Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des. 2016, 22 (14): 2160-9.
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What is pathophysiology of lung cancer?
The pathophysiology of lung cancer refers to the changes in the normal physiological processes and mechanisms that occur in the development and progression of lung cancer.
Lung cancer is a complex disease that arises from the uncontrolled growth and division of abnormal cells in the lungs.
These cells can form tumors and spread to other parts of the body, leading to various symptoms and complications.
The pathophysiology of lung cancer involves several factors, including genetic mutations, environmental factors, and lifestyle choices.
Genetic mutations can occur in the DNA of lung cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can be caused by exposure to carcinogens, such as tobacco smoke, radon, asbestos, and air pollution.
Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is further divided into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.
The pathophysiology of these types of lung cancer can differ, as they have different genetic mutations and respond differently to treatment.
The pathophysiology of lung cancer also involves the interaction between cancer cells and the surrounding tissue, including the immune system.
Cancer cells can evade the immune system, allowing them to grow and spread unchecked.
Additionally, the tumor microenvironment can promote tumor growth and metastasis by providing a supportive environment for cancer cells.
The pathophysiology of lung cancer is a complex and dynamic process, and researchers are continuously working to better understand the underlying mechanisms to develop more effective treatments and improve patient outcomes.
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