La enfermedá d'Alzheimer ye un desorde neurodegenerativo progresivu qu'afecta principalmente al celebru, causando perda de memoria, deterioru cognitivu y cambeos de comportamientu.
La causa esacta de la enfermedá d'Alzheimer nun ta dafechu entendida, pero créese que ye resultáu d'una combinación de factores xenéticos, ambientales y de estilu de vida.
Dellos factores que pueden contribuyir al desenvolvimientu de la enfermedá d'Alzheimer inclúin:
1. La xenética: Identificáronse ciertos xenes qu'aumenten el riesgu de desenvolver la enfermedá d'Alzheimer, particularmente'l xene de la apolipoproteína E (APOE).
2. Edá: El riesgu de desenvolver la enfermedá d'Alzheimer aumenta cola edá, y la mayoría de les persones son diagnosticaes dempués de los 65 años.
3. Antecedentes familiares: Si hai antecedentes familiares de enfermedá d'Alzheimer, puede aumentar el riesgu de desenvolver la enfermedá.
4. Lesiones na cabeza: Si nun se curó, especialmente les que causen perda de conciencia, puede aumentar el riesgu de contraer la enfermedá d'Alzheimer.
5. Factores de riesgu cardiovascular: Enfermedaes como la presión arterial alta, el colesterol altu y la diabetes pueden aumentar el riesgu de desenvolver la enfermedá d'Alzheimer.
6. Factores de la vida: Un estilu de vida sedentariu, una dieta deficiente y la falta d'estimu mental pueden aumentar el riesgu de contraer la enfermedá d'Alzheimer.
7. Inflamación: La inflamación crónica del celebru puede contribuyir al desenvolvimientu de la enfermedá d'Alzheimer.
8. Estrés oxidativo: Un desequilibriu ente la producción de radicales llibres y la capacidá del cuerpu pa desintoxicarlos puede contribuyir al desenvolvimientu de la enfermedá de Alzheimer.
9. Plaques amiloides y enredos neurofibrilares: L'acumuladura de plaques amiloides y enredos neurofibrilares nel celebru ye un signu distintivu de la enfermedá d'Alzheimer, pero nun se entiende dafechu'l papel que desempeñen nel desenvolvimientu de la enfermedá.
Ye importante tener en cuenta que la causa de la enfermedá d'Alzheimer ye complexa y probablemente implica una combinación d'estos factores.
La investigación ta en cursu pa entender meyor los mecanismos subyacentes y desenvolver tratamientos efectivos pa esta condición devastadora.
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Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.
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What causes alzheimer?
Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.
The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.
Some of the factors that may contribute to the development of Alzheimer's disease include:
1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.
2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.
3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.
4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.
5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.
6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.
7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.
8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.
9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.
It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.
Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.
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