Mae urticaria, a elwir yn gyffredin yn hives, yn gyflwr croen sy'n cael ei nodweddu gan ymddangosiad gwenyn coch, codiedig ar y croen.
Mae pathophysiology urticaria yn cynnwys rhyddhau histamin a chyfryngwyr llid eraill o gelloedd mast, sy'n gelloedd imiwnedd a geir yn y croen a meinweoedd eraill.
Mewn urticaria difrifol, mae rhyddhau histamin a chyfryngwyr eraill yn cael ei sbarduno gan adwaith alergig i allergen penodol, fel bwyd, meddyginiaeth, neu chwistrellu pryfed.
Mae hyn yn achosi i'r celloedd mast degranwlu, gan ryddhau histamin a chyfryngwyr eraill sy'n achosi i'r gwydrau gwaed ddod yn gollwng, gan arwain at ffurfio gwydrau.
Mewn urticaria cronig, mae'r achos yn aml yn anhysbys, ond credir ei fod yn gysylltiedig â mecanwaith autoimmune.
Yn yr achos hwn, mae'r corff yn cynhyrchu autoantibodies sy'n targedu'r derbynnydd IgE affinity uchel (FcεRI) ar gelloedd mast, gan arwain at eu actifadu a rhyddhau histamin a chyfryngwyr eraill.
Yn yr urticaria acwtaidd a chronig, mae rhyddhau histamin a chyfryngwyr eraill yn arwain at y symptomau nodweddiadol o chwistrellu, coch, a chwistrellu.
Mae'r driniaeth fel arfer yn cynnwys defnyddio gwrthhistaminau i atal effeithiau histamin a lleihau symptomau.
Mewn achosion difrifol, gellir defnyddio meddyginiaethau eraill fel corticosteroidau neu omalizumab i reoli'r cyflwr.
Wahlgren CF: Pathophysiology of itching in urticaria and atopic dermatitis. Allergy. 1992, 47 (2 Pt 1): 65-75.
Raap U, Liekenbröcker T, Wieczorek D, Kapp A, Wedi B: [New therapeutic strategies for the different subtypes of urticaria]. Hautarzt. 2004, 55 (4): 361-6.
[Recommendations for the diagnosis and treatment of urticaria in children]. Arch Argent Pediatr. 2021, 119 (2): S54-S66.
Brzoza Z, Grzeszczak W, Rogala B, Trautsolt W, Moczulski D: Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Allergol Immunopathol (Madr). , 42 (4): 302-6.
Sweeney TM, Dexter WW: Cholinergic urticaria in a jogger: ruling out exercise-induced anaphylaxis. Phys Sportsmed. 2003, 31 (6): 32-6.
Gwaharddiad cyfrifoldeb: meddygol
Mae'r wefan hon yn cael ei ddarparu at ddibenion addysgol a gwybodaeth yn unig ac nid yw'n darparu cyngor meddygol neu wasanaethau proffesiynol.
Ni ddylid defnyddio'r wybodaeth a ddarperir i ddiagnosio neu drin broblem neu glefyd iechyd, a dylai'r rhai sy'n ceisio cyngor meddygol personol ymgynghori â meddyg trwyddedig.
Sylwch fod y rhwydwaith niwrol sy'n cynhyrchu atebion i'r cwestiynau, yn arbennig o anghywir pan ddaw i gynnwys rhifol. Er enghraifft, nifer y bobl sy'n cael diagnosis o glefyd penodol.
Ceisiwch gyngor eich meddyg neu ddarparwr iechyd cymwys arall bob amser ynghylch cyflwr meddygol. Peidiwch byth ag anwybyddu cyngor meddygol proffesiynol neu ohirio ei geisio oherwydd rhywbeth rydych chi wedi ei ddarllen ar y wefan hon. Os ydych chi'n meddwl y gallai fod gennych argyfwng meddygol, ffonwch 911 neu ewch i'r ystafell brys agosaf ar unwaith. Nid oes unrhyw berthynas meddyg-cleifion yn cael ei greu gan y wefan hon na'i ddefnydd. Nid yw BioMedLib na'i weithwyr, na unrhyw gyfrannwr i'r wefan hon, yn gwneud unrhyw gynrychiolaeth, yn glir neu'n awgrymol, mewn perthynas â'r wybodaeth a ddarperir yma na'i ddefnydd.
Gwrthod cyfrifoldeb: hawlfraint
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Os ydych chi'n credu mewn ffydd da bod unrhyw gynnwys neu ddeunydd a wnaed ar gael mewn cysylltiad â'n gwefan neu'n gwasanaethau yn torri eich hawlfraint, gallwch chi (neu'ch asiant) anfon hysbysiad atom yn gofyn i'r cynnwys neu'r ddeunydd gael ei ddileu, neu fod mynediad ato wedi'i rwystro.
Rhaid i rybuddion gael eu hanfon yn ysgrifenedig trwy e-bost (gweler adran "Cyflwyniad" am gyfeiriad e-bost).
Mae'r DMCA yn gofyn i'ch hysbysiad o dorri hawlfraint honedig gynnwys y wybodaeth ganlynol: (1) disgrifiad o'r gwaith hawlfraint sy'n destun y dorri hawlfraint honedig; (2) disgrifiad o'r cynnwys sy'n dorri hawlfraint honedig a gwybodaeth ddigonol i'n galluogi i ddod o hyd i'r cynnwys; (3) gwybodaeth gyswllt i chi, gan gynnwys eich cyfeiriad, rhif ffôn a chyfeiriad e-bost; (4) datganiad gan chi bod gennych gred ffyddlon nad yw'r cynnwys yn y ffordd sy'n cwyno amdano wedi'i awdurdodi gan berchennog yr hawlfraint, neu ei asiant, neu gan weithredu unrhyw gyfraith;
(5) datganiad gennych chi, wedi'i lofnodi o dan gosb llygredd, bod y wybodaeth yn y hysbysiad yn gywir ac bod gennych chi'r awdurdod i orfodi'r hawlfraint sy'n cael eu troseddu;
a (6) llofnod corfforol neu electronig o berchennog y hawlfraint neu berson wedi'i awdurdodi i weithredu ar ran perchennog y hawlfraint.
Gall methu â chynnwys yr holl wybodaeth uchod arwain at oedi wrth brosesu'ch cwyn.
Cysylltwch
Anfonwch e-bost i ni gyda unrhyw gwestiwn / awgrym.
What is pathophysiology of urticaria?
Urticaria, commonly known as hives, is a skin condition characterized by the appearance of itchy, raised, red welts (wheals) on the skin.
The pathophysiology of urticaria involves the release of histamine and other inflammatory mediators from mast cells, which are immune cells found in the skin and other tissues.
In acute urticaria, the release of histamine and other mediators is triggered by an allergic reaction to a specific allergen, such as food, medication, or insect sting.
This causes the mast cells to degranulate, releasing histamine and other mediators that cause blood vessels to become leaky, leading to the formation of wheals.
In chronic urticaria, the cause is often unknown, but it is thought to be related to an autoimmune mechanism.
In this case, the body produces autoantibodies that target the high-affinity IgE receptor (FcεRI) on mast cells, leading to their activation and the release of histamine and other mediators.
In both acute and chronic urticaria, the release of histamine and other mediators leads to the characteristic symptoms of itching, redness, and swelling.
Treatment typically involves the use of antihistamines to block the effects of histamine and reduce symptoms.
In severe cases, other medications such as corticosteroids or omalizumab may be used to control the condition.
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