Na pathophysiology ni colon cancer e vakaibalebaletaki ena ka e dau yaco kei na ka e vakavuna na kena tubu kei na kena tete.
Na colon cancer, e kilai tale ga me colorectal cancer, e dua na mataqali kenisa e tekivu ena colon se rectum, e tiki ni gacagaca levu.
E dau tekivu ena tubu ni yago e vakatokai na polyp, e rawa ni lai tini ena kenisa.
Na mate oqo e rawa ni vakavuna na kena dewa ina dua tale na mataqali manumanu.
E rawa ni yaco na veisau ena sela ni colon, e vakavuna me tubu qai tawase na sela.
Na veisau oqo e rawa ni dewavi ira na gone se ra qai vulica, e rawa tale ga ni vakaleqa e so na gene e vakaitavi ena tubu ni sela, kena wasei, kei na kena vakavinakataki.
E rawa ni vakavuna tale ga na kenisa ni colon na inflammation ena colon, e vu mai na inflammatory bowel disease.
Na vuvuce e sega ni wali rawa e rawa ni vakavuna na kena buli na wainimate e vakabulabulataka na tubu kei na tawase ni sela, e rawa ni vakavuna na kenisa.
E rawa ni vakavuna tale ga na kenisa ni gadro na kakana eda kania, ivakarau ni noda bula, kei na noda ceguva na wainimate.
Kena ivakaraitaki, na kakana e levu kina na lewenimanumanu damudamu kei na lewenimanumanu e sa caka oti, e rawa ni vakavuna na kenisa ni gadro.
E so tale na ka me vaka na levulevu sivia, vakatavako, kei na sega ni vakaukaua yago, e rawa ni vakavuna na mate oqo.
Ni sa tauvi koya na kenisa ni colon, e rawa ni toso ina vica na kena iwasewase, mai na kena e se qai tekivu e tiko ga ena colon me yacova na kena sa tete ina so tale na tikiniyago.
Na sela ni kenisa e rawa ni curuma na tikiniyago kei na gacagaca voleka, qai rawa ni dewa ina gacagaca ni dra se dra ina vanua yawa, me vaka na yate se yatevuso.
E dau vakayagataki na chemotherapy, radiation therapy, kei na veisele me wali kina na kenisa ni colon.
E bibi me kilai totolo qai qaravi na kenisa ni colon ni rawa ni wali totolo.
Na vakadidike e dau caka wasoma, me vaka na colonoscopy, e rawa ni kilai kina na kenisa ni gadro ni se qai tekivu, ni se rawarawa sara na kena qaravi.
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Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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