La fisiopatologjie dal diabete e si riferìs al studi dai procès fisiologjics disordenâts che a puartin al svilup dal diabete mellit.
Il diabete mellit e je une malatie metaboliche caraterizade di nivei di zucar (glucosi) alts tal sanc che a son il risultât di difiets inte secrezion di insuline, azion di insuline o ducj i doi.
La fisiopatologjie dal diabete e rivuarde la interazion complesse di fatôrs gjenetics, ambientâi e dal mût di vivi che a contribuissin al svilup de malatie.
Intal diabete di tip 1, la fisiopatologjie e rivuarde une distruzion autoimune des celulis beta che a produsin la insuline intal pancreas, puartant a une mancjance inte produzion di insuline.
Chest al puarte a une inabilitât di regolâ i nivei di glucosi intal sanc, puartant a iperglicemie (aument di zucar intal sanc).
Intal diabete di tip 2, la fisiopatologjie e je plui complesse e e cjape dentri sedi la resistence ae insuline sedi une ridusude secrezion di insuline.
La resistence ae insuline e sucêt cuant che lis celulis dal cuarp no rispuindin in mût adeguât ae insuline, puartant ae inabilitât di doprâ in mût eficaç il glucosi come energjie.
Chest al fâs sì che il pancreas al produsi plui insuline par superâ la resistence, ma cul timp, il pancreas al podarès no jessi in grât di tignî il ritmi cu la domande, puartant a un câl inte produzion di insuline.
Il diabete gestazionâl, che al sucêt dilunc de gravidance, al è causât di cambiaments ormonâi che a puartin ae resistence ae insuline.
La placente e prodûs ormonis che a puedin blocâ la azion de insuline, puartant a un aument dai nivei di glucosi intal sanc.
La fisiopatologjie dal diabete e compuarte ancje il svilup di complicazions, come il dam ai vasions, ai gnerfs e ai orghins, che a puedin puartâ a problemis di salût seri come malatiis cardiachis, ictus, malatiis dai rens e pierdite de vision. ❚
Capî la fisiopatologjie dal diabete al è fondamentâl par svilupâ trataments eficaçs e strategjiis di prevenzion par cheste malatie croniche.
Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.
Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.
Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.
Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.
Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.
Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.
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What is pathophysiology of diabetes?
Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.
Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.
The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.
In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.
This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).
In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.
Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.
This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.
Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.
The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.
The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.
Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.
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