Pathophysiology de kansè pwostat refere a sous mekanis ak pwosesis ki mennen pou devlopman ak pwogresyon maladi a.
Kansè pwostat se yon timè malfezan ki soti nan selil pwostat la, ki se yon ti ògàn ki gen fòm zanmann ki chita anba blad pipi gason.
Pwostat la pwodui likid seminal, ki nouri ak transpòte espèm.
Kòz egzak kansè pwostat la pa konprann nèt, men gen plizyè faktè ki konnen ki ogmante risk pou devlope maladi a.
Sa yo enkli laj, istwa fanmi, ras, ak sèten mitasyon jenetik.
Kansè pwostat pi komen nan gason ki pi gran, ak majorite ka yo ki rive nan gason ki gen plis pase 65 lane.
Anplis de sa, gason ki gen fanmi ki gen kansè pwostat gen plis chans pou yo gen maladi sa a, menm jan sa ye pou gason ki se Afriken e pou gason ki se desandan Karayib.
Pathophysiology de kansè pwostat enplike kwasans san kontwòl ak divizyon cellules nan pwostat la.
Sa ka rive akòz mitasyon jenetik ki mennen nan ekspresyon twòp nan sèten faktè kwasans oswa inaktivasyon nan jèn suppressor timè.
Mitasyon sa yo kapab lakòz kwasans selil yo pa kontwole, sa ki mennen nan fòmasyon yon timè.
Pandan timè a ap grandi, li ka anvayi tisi ak ògàn ki toupre yo, tankou blad pipi, rektòm, ak ne lenfatik ki toupre yo.
Nan kèk ka, selil kansè yo ka kraze lwen timè prensipal la epi gaye nan lòt pati nan kò a atravè san an oswa sistèm lenfatik, yon pwosesis ke yo rekonèt kòm metastaz.
Yon fwa kansè a gaye, li ka pi difisil pou trete.
Kansè pwostat kapab enfliyanse tou pa faktè ormon, patikilyèman òmòn testostewòn.
Testostewòn kapab ankouraje kwasans selil kansè pwostat yo, e anpil tretman pou kansè pwostat vize pou diminye nivo òmòn sa a oswa bloke efè li yo.
An rezime, patofizyoloji kansè pwostat la enplike kwasans ak divizyon san kontwòl selil yo nan glann pwostat la, ki kapab enfliyanse pa faktè jenetik, òmòn ak anviwònman.
Konprann ki sa ki kache dèyè maladi a enpòtan anpil pou devlope tretman efikas ak amelyore rezilta pou pasyan ki gen kansè pwostat.
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Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.
Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.
Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.
Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.
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What is pathophysiology of prostate cancer?
The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.
Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.
The prostate gland produces seminal fluid, which nourishes and transports sperm.
The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.
These include age, family history, race, and certain genetic mutations.
Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.
Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.
The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.
This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.
These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.
As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.
In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.
Once the cancer has spread, it can be more difficult to treat.
Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.
Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.
In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.
Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.
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