Pathophysiology nke ọrịa cancer ara na-ezo aka na mgbanwe ndị na-adịghị mma na usoro na usoro anụ ahụ nkịtị nke na-eme na mmepe na ọganihu nke ọrịa cancer ara.
Ọ na-agụnye nnyocha nke usoro ihe ndị dị ndụ na nke ụmụ irighiri ihe ndị na-eduga n'uto na mgbasa nke mkpụrụ ndụ kansa n'ahụ́ ara.
Nke a na-agụnye ihe ndị metụtara mkpụrụ ndụ ihe nketa, ihe ndị metụtara mkpụrụ ndụ ihe nketa, na ihe ndị metụtara gburugburu ebe obibi bụ́ ndị na-eme ka ọrịa cancer ara malite, na-akwalite, ma na-aga n'ihu.
Ụfọdụ n'ime isi mgbanwe pathophysiological na ọrịa cancer ara na-agụnye:
1. Mgbanwe nke mkpụrụ ndụ ihe nketa: Mgbanwe nke mkpụrụ ndụ ihe nketa ụfọdụ, dị ka BRCA1 na BRCA2, pụrụ ime ka ihe ize ndụ nke ịrịa ọrịa cancer ara mụbaa.
A pụrụ iketa ma ọ bụ nweta mgbanwe ndị a n'oge ndụ mmadụ.
2. Ọdịiche nke homonụ: Homonụ, karịsịa estrogen, pụrụ ikere òkè n'ịzụlite na uto nke ọrịa cancer ara.
Enweghị nguzozi n'ọkwa homonụ ma ọ bụ ịnọ n'okpuru estrogen gabigara ókè pụrụ ime ka ihe ize ndụ nke ịrịa ọrịa cancer ara mụbaa.
3. Ọrịa ọgbụgba: Ọrịa ọgbụgba na-adịgide adịgide n'ime akwara ara pụrụ inye aka n'ịzụlite ọrịa cancer ara site n'ịkwalite uto na ịdị ndụ nke mkpụrụ ndụ cancer.
4. Ọnọdụ microenvironment nke akpụ: Ọnọdụ gbara akpụ ahụ gburugburu, gụnyere extracellular matrix, mkpụrụ ndụ ahụ ji alụso ọrịa ọgụ, na akwara ọbara, pụrụ imetụta uto na mgbasa nke ọrịa cancer ara.
5. Metastasis: Ọrịa cancer ara pụrụ ịgbasa n'akụkụ ndị ọzọ nke ahụ site n'usoro lymphatic ma ọ bụ n'ọbara, na-eduga n'ịmepụta ọrịa ndị ọzọ n'ahụ ndị dị anya.
Ịghọta pathophysiology nke ọrịa cancer ara dị oké mkpa maka ịzụlite usoro mgbochi, nchọpụta n'oge, na ọgwụgwọ dị irè.
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Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
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What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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