Ti pathophysiology ti kanser ti suso tuktukoyenna dagiti di normal a panagbalbaliw kadagiti normal a proseso ken mekanismo ti bagi a mapasamak iti itatanor ken panagsaknap ti kanser ti suso.
Ramanenna ti panagadal kadagiti kangrunaan a biolohikal ken molekular a mekanismo a mangiturong iti di makontrol a panagdakkel ken panagsaknap dagiti selula ti kanser iti tisyu ti suso.
Ramanen daytoy dagiti genetic, epigenetic, ken dagiti makagapu iti aglawlaw a pakaigapuan, pakaigapuan, ken pakaigapuan ti panagsakit ti kanser ti suso.
Dadduma kadagiti kangrunaan a panagbalbaliw ti pathophysiology iti kanser ti suso iramanna:
1. Genetic mutations: Dagiti mutation iti sumagmamano a gene, kas iti BRCA1 ken BRCA2, mabalin a mangpadakkel iti posibilidad a maaddaan iti kanser ti suso.
Dagitoy a panagbalbaliw ti gene ket mabalin a matawid wenno maadda bayat ti panagbiag ti maysa a tao.
2. Di panagpapada ti hormone: Dagiti hormone, nangruna ti estrogen, mabalin a dakkel ti maitulongda iti itatanor ken panagadu ti kanser ti suso.
Ti di natimbeng a kaadu ti hormone wenno ti sobra nga estrogen ti mangpakaro iti posibilidad a maaddaan iti kanser ti suso.
3. Pannaka-inflammation: Ti napaut a pannaka-inflammation iti tisyu ti suso mabalin a pakaigapuan ti panagsakit iti kanser ti suso babaen ti panangparegtana iti panagdakkel ken panagbiag dagiti selula ti kanser.
4. Ti aglawlaw ti tumor: Ti aglawlaw ti tumor, agraman ti extracellular matrix, immune cells, ken urat, mabalin nga apektaranna ti panagdakkel ken panagsaknap ti kanser ti suso.
5. Metastasis: Ti kanser ti suso mabalin nga agsaknap iti dadduma a paset ti bagi babaen ti lymphatic system wenno dara, nga agbanag iti pannakapataud dagiti maikadua a tumor kadagiti adayo nga organo.
Ti pannakaawat iti pathophysiology ti kanser ti suso ket napateg iti panangpatanor kadagiti epektibo a pamay-an a manglapped, nasapa a mangilasin, ken mangagas.
Underwood SM: Breast cancer in African American women: nursing essentials. ABNF J. , 17 (1): 3-14.
Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.
Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
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What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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