Hkum shan cancer a pathophysiology gaw hpa rai kun?
Dai majaw, ma hkum ni hta ana byin wa ai shaloi, ma hkum ni a hkum hkrang hta byin wa ai lam ni hpe, ana kanu a ana kanu (breast cancer) ngu nna shamying ai.
Dai gaw, sai hta ana byin wa ai shaloi, n hkang lu ai hku nna, sai hta ana kap wa ai lam hpe sawk sagawn ai lam re.
Dai hta, sai n'gup a ana byin wa hkra galaw ya ai, grau sawng wa hkra galaw ya ai, hte grau sawng wa hkra galaw ya ai, ginru ginsa lam (genetic), shingra masa lam (environmental) ni lawm ai.
Nbawnu a cancer hta byin ai ahkyak ai pathophysiological galai shai ai lam ni gaw:
1. Genetic mutation: BRCA1 hte BRCA2 zawn re ai gene nkau mi hta byin ai mutation gaw, chyu machyi byin wa na matu shoihpa grau nga ai.
Dai galai shai ai lam ni gaw, masha langai a prat hta lu la wa ai (sh) sali wunli hku nna lu la wa ai re.
2. Hormon ni n rap ra ai lam: Hormon ni, grau nna estrogen ni gaw, chyu nra a cancer byin wa ai hte galu kaba wa ai hta ahkyak ai lam nga ai.
Hormon ni n rap ra ai (sh) estrogen grai law ai majaw, ma chyangai hta cancer byin chye ai.
3. Hkum machyi ai lam: Lawu lahpa hta machyi ai lam ni nga wa yang, dai gaw hkum machyi ai lam ni grau nna byin wa hkra galaw ya ai.
4. Hkum hkrang hta nga ai ana ni: Hkum hkrang kata na ana ni, makawp maga ai atsam rawng ai hkum hkrang a hkum hkrang daw ni hte sai lam ni gaw, hkum hkrang hta nga ai ana ni grau kaba wa na matu karum ya lu ai.
5. Hkum shan hta ana kap ai lam (Metastasis): Hkum shan hta ana kap ai gaw sai hte kaga hkum hkrang daw ni de mung kap wa nna, kaga hkum hkrang daw ni hta mung byin wa chye ai.
N-gu hkri ana hpe atsawm chye na lu na matu, dai ana hpe atsawm ninghkap lu na matu, dai hpe aten dep chye lu na matu hte tsi lajang lu na matu ahkyak ai.
Underwood SM: Breast cancer in African American women: nursing essentials. ABNF J. , 17 (1): 3-14.
Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.
Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
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['(5) N teng n man ai sakse hkam ai lam hte seng nna, nang masat da ai hte maren, shana ai lam hta lawm ai shiga ni gaw teng man ai hte, nang tawt lai ai ngu ai copyright hpe hkan sa na ahkang nga ai lam.']
['hte (6) copyright madu a mying hte galaw na ahkang lu ai wa a hkum hkrang (sh) electronic signature.']
['Lahta na lam ni hpe n ka bang ai rai yang, nang shagun ai laika hpe hpang hkrat ai hte n mai htang ai.']
['Matut Mahkai U']
['Gara hku mung san mayu yang email hte shana ya rit.']
What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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