How to treat Prostate cancer?

['Welisi hɔɔlʋʋ kʋnɛ']

Ɛzɩma pɩwɛɛ se pala nɛ palʋbɩnɩ kansɛɛrɩ kʋdɔŋ?

Kʋdɔŋ ŋgʋ kɩ-taa palakɩnɩ tʋmɩyɛ calɩm yɔ, kɩpɩzɩɣ nɛ kɩkpa ɛyʋ ɖoŋ nɛ halɩ kɩpɩzɩɣ nɛ kɩwaa-ɩ.

Kʋdɔmɩŋ waʋ nʋmɔŋ nɩɩyɩ yɔ:

1. Pɩpɔzʋʋ se pañɩnɩ nɛ pana se kʋdɔŋ piye nɖɩ ɖɩ-tɔm cɛyaa yaa ɖɩtɩ cɛyaa.

Pɩpɩzɩɣ nɛ pɩwazɩ abalaa mba pɛwɛnɩ kʋdɔŋ ŋgʋ yɔ.

2. (a) Tʋmɩyɛ nɖɩ payaɣ se "prostatectomie" yɔ: Palakɩ tʋmɩyɛ naɖɩyɛ nɛ palɩzɩ ɛyʋ nandʋ ndʋ payaɣ se "prostate" yɔ.

Papɩzɩɣ nɛ palabɩ-kʋ nɛ pɩsaʋ yaa palɩzɩ-kʋ nɛ pɩsaʋ cikpeluu nakʋyʋ yɔɔ.

3. (a) Calɩm mbʋ payaɣ se radiation yɔ: Palakɩnɩ calɩm mbʋ tʋmɩyɛ se pɩkʋ kʋdɔmɩŋ.

Papɩzɩɣ nɛ paɖʋ-kʋ ɛyʋ tomnaɣ taa (lɔɔɖɩyɛ naɖɩyɛ taa) yaa pɔsɔ-kʋ kʋdɔŋ piye taa.

4. Kʋdɔŋ ŋgʋ payaɣ se cancer yɔ: Kʋdɔŋ ŋgʋ kɩsɩɣnɩ abalʋ se ɛwɛɛnɩ abalɩtʋ tɛ ɖoŋ weyi payaɣ se hormone yɔ nɛ kɩsɩɣnɩ ɖɔɖɔ halʋ se ɛtaakɩlɩɣ kʋdɔŋ ŋgʋ kʋ-taa tɔlʋʋ.

Papɩzɩɣ nɛ palabɩnɩ-kʋ tʋmɩyɛ kʋɖʋm kʋɖʋm yaa paɖʋʋ-kʋ ɖɔɖɔ kɔyɛ lɛɛɖɛ taa.

5. (a) Ɛzɩma palakɩ kʋdɔmɩŋ nɩɩyɩ? (b) Nɛ ɛzɩma pawaɣ kʋdɔmɩŋ ɛnɩ?

Pɩpɩzɩɣ nɛ pɩkɛ ɖɔɖɔ calɩm taa kʋdɔŋ ŋgʋ kɩɖɛwa nɛ kɩtalɩ tomnaɣ hɔɔlɩŋ lɛɛŋ taa yɔ.

6. Kʋdɔmɩŋ waʋ nʋmɔŋ: Nʋmɔŋ ɛnɩ ɩsɩɣnɩ kʋdɔmɩŋ waʋ wondu se tɩpɩzɩ nɛ tɩlʋbɩnɩ kʋdɔŋ ŋgʋ.

Pɩpɩzɩɣ nɛ pɩwazɩ-ɩ ɖɔɖɔ ye ɛ-kʋdɔŋ ɛɛkɩlɩɣ kɩlʋʋ ɖoŋ yaa ye kʋdɔmɩŋ lɛɛŋ ɩɩwazɩɣ-ɩ yɔ.

Kʋdɔmɩŋ waʋ nʋmɔŋ nɩɩyɩ wɛɛ nɛ ɩsɩɣnɩ kʋdɔmɩŋ tɩnaa se palʋbɩnɩ pa-kʋdɔmɩŋ.

Pɩpɩzɩɣ nɛ pɩwazɩ-ɩ ɖɔɖɔ ye ɛ-kʋdɔŋ ɛɛkɩlɩɣ kɩlʋʋ ɖoŋ yaa ye kʋdɔmɩŋ lɛɛŋ ɩɩwazɩɣ-ɩ yɔ.

8. (a) Ɛzɩma palakɩnɩ tʋmɩyɛ calɩm yɔ: Palakɩnɩ calɩm tʋmɩyɛ se pawaa kʋdɔmɩŋ nɩɩyɩ. (b) Ɛzɩma calɩm pɩzɩɣ nɛ pɩwaa kʋdɔmɩŋ ɛnɩ?

Pɩpɩzɩɣ nɛ pɩwazɩ-ɩ ɖɔɖɔ ye ɛ-kʋdɔŋ ɛɖaɣnɩ paɣzʋʋ yaa ye kʋdɔŋ ŋgʋ kɩlɩ ɛ-yɔɔ kʋdɔmɩŋ lɛɛŋ taa yɔ.

9. (a) Ɛzɩma palakɩ stérilet ŋgʋ yɔ: Palakɩ-kʋ nɛ ɖoŋ nɩɩyɩ nɛ pañaɣzɩɣnɩ calɩm se pɩkʋ kʋdɔŋ piye.

Pɩpɩzɩɣ nɛ pɩwazɩ-ɩ ɖɔɖɔ ye ɛ-kʋdɔŋ ɛɖaɣnɩ paɣzʋʋ yaa ye kʋdɔŋ ŋgʋ kɩlɩ ɛ-yɔɔ kʋdɔmɩŋ lɛɛŋ taa yɔ.

10. (a) Ye pɔtɔm se ɛyʋ ɛɖaŋ nɛ ɛna se kʋdɔŋ ŋgʋ kɩkaɣ cɛyʋʋ yaa kɩkaɣ cɛyʋʋ yɔ, pʋ-tɔbʋʋ lɛ se pɩwɛɛ se ɛcɔnɩ kʋdɔŋ ŋgʋ kɩ-yɔɔ camɩyɛ nɛ ɛtaŋɩɣ ɛ-wayɩ se ɛna se kɩcɛyaa yaa kɩtɩcɛyaa se ɛtasɩ-kʋ cɛyʋʋ yaa we? (b) Nɛ ye kʋdɔŋ ŋgʋ kɩ-tɔm ɛyɔɔdʋʋ yɔ, pɩwɛɛ se ɛɖaŋ nɛ ɛna se kɩkaɣ cɛyʋʋ yaa kɩtɩcɛyʋʋ se ɛtasɩ-kʋ cɛyʋʋ yaa we?

Pɩpɩzɩɣ nɛ pɩwazɩ ɖɔɖɔ abalaa mba pasʋtʋyaa nɛ palʋkɩnɩ kansɛɛrɩ kʋdɔŋ nɛ kʋdɔmɩŋ lɛɛŋ yɔ.

Pɩcɛyaa se ŋyɔɔdɩnɩ ɖɔkɔtɔ weyi ɛcɔŋnɩ ñɔ-yɔɔ yɔ nɛ ŋna se ɛbɛ pɩzɩɣ pɩsɩnɩ-ŋ nɛ ŋlʋbɩnɩ kʋdɔŋ ŋgʋ.

['Takayɩhatʋ ndʋ tɩtamsɩna \\ yɔ']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Wang Y, Chen J, Wu Z, Ding W, Gao S, Gao Y, Xu C: Mechanisms of enzalutamide resistance in castration-resistant prostate cancer and therapeutic strategies to overcome it. Br J Pharmacol. 2021, 178 (2): 239-261.

Talkar SS, Patravale VB: Gene Therapy for Prostate Cancer: A Review. Endocr Metab Immune Disord Drug Targets. 2021, 21 (3): 385-396.

Šamija I, Fröbe A: CHALLENGES IN MANIPULATING IMMUNE SYSTEM TO TREAT PROSTATE CANCER. Acta Clin Croat. 2019, 58 (Suppl 2): 76-81.

Akaza H, Hinotsu S, Usami M, Ogawa O, Kagawa S, Kitamura T, Tsukamoto T, Naito S, Hirao Y, Murai M, Yamanaka H, Namiki M: The case for androgen deprivation as primary therapy for early stage disease: results from J-CaP and CaPSURE. J Urol. 2006, 176 (6 Pt 2): S47-9.

Abraham-Miranda J, Awasthi S, Yamoah K: Immunologic disparities in prostate cancer between American men of African and European descent. Crit Rev Oncol Hematol. 2021, 164 (): 103426.

de Vrij J, Willemsen RA, Lindholm L, Hoeben RC, Bangma CH, Barber C, Behr JP, Briggs S, Carlisle R, Cheng WS, Dautzenberg IJ, de Ridder C, Dzojic H, Erbacher P, Essand M, Fisher K, Frazier A, Georgopoulos LJ, Jennings I, Kochanek S, Koppers-Lalic D, Kraaij R, Kreppel F, Magnusson M, Maitland N, Neuberg P, Nugent R, Ogris M, Remy JS, Scaife M, Schenk-Braat E, Schooten E, Seymour L, Slade M, Szyjanowicz P, Totterman T, Uil TG, Ulbrich K, van der Weel L, van Weerden W, Wagner E, Zuber G: Adenovirus-derived vectors for prostate cancer gene therapy. Hum Gene Ther. 2010, 21 (7): 795-805.

Lee E, Ha S, Logan SK: Divergent Androgen Receptor and Beta-Catenin Signaling in Prostate Cancer Cells. PLoS One. 2015, 10 (10): e0141589.

['Tɔm ndʋ tɩ-yɔɔ ɖitisiɣ yɔ: ɖɔkɔtɔ']

['Ye ŋwobi intɛrnɛɛtɩ lone ɖɩnɛ ɖɩ-yɔɔ yɔ, ŋpɩzɩɣ nɛ ŋkpɛlɩkɩ tɔm sakɩyɛ ɖɩ-yɔɔ.']

['Pɩtɩpɔzɩ se patɩŋnɩ tɔm ndʋ pama takayaɣ kanɛ ka-taa yɔ tɩ-yɔɔ nɛ pañɩnɩ kʋdɔŋ nakʋyʋ yaa pawaa-kʋ.']

['Tɩlɩ camɩyɛ se ordinatɛɛrɩ yɔɔ tɔm ndʋ pɔpɔzʋʋ yɔ, tɩ-yɔɔ cosuu wɛ kaɖɛ, kɔzɩ kɔzɩ alɩwaatʋ ndʋ tɩ-taa pɔpɔzʋʋ tɔm natʋyʋ nɛ tɩ-taa tɔm pee tɩɖɔɔ yɔ.']

['Paa ɛzɩmtaa lɛ, pɔzɩ lɔŋ tasʋʋ fɛɖʋ weyi ɛsɩm ñɔ-yɔɔ tɔm sakɩyɛ yɔ nɛ ɛyɔɔdɩ-ŋ kʋdɔŋ ŋgʋ ŋwɛna yɔ kɩ-tɔm. Taayele nɛ lɔŋ tasʋʋ mbʋ fɛɖʋ ɛnʋ ɛha-ŋ yɔ, pɩɖɛɛ ñɔ-yɔɔ yaa ŋyele-pʋ ñɩnʋʋ mbʋ pʋyɔɔ yɔ ŋkalɩ tɔm natʋyʋ intɛrnɛɛtɩ lone ɖɩnɛ ɖɩ-yɔɔ. Ye ŋmaɣzɩɣ se pɩwɩɣ-ŋ yɔ, yaa ɛyaa 911 yaa ŋwolo ɖɔkɔtɔ ŋgʋ kɩñɔtɩnɩ-ŋ yɔ kɩ-taa kpaagbaa.']

['Takayɩhatʋ ndʋ tɩtamsɩna \\ Paɣtʋ \\ yɔ']

['Digital Millennium Copyright Act 1998 ñɩŋgʋ, 17 U.S.C. § 512 (DMCA) haɣ waɖɛ mba pɛwɛnɩ waɖɛ se pala tʋmɩyɛ intɛrnɛɛtɩ yɔɔ yɔ se pala mbʋ pɩkaɖɩɣnɩ waɖɛ nɖɩ pɛwɛna Etaazuunii ɛjaɖɛ taa yɔ.']

['Ye ŋmaɣzɩɣ se tɔm natʋyʋ yaa wonuu nakʋyʋ yɔɔ pama tɔm intɛrnɛɛtɩ lone ɖɩnɛ ɖɩ-yɔɔ yaa intɛrnɛɛtɩ lone ɖɩnɛ ɖɩ-yɔɔ nɛ pɩkaɖɩɣnɩ ña-paɣtʋ yɔ, ña-maɣmaɣ yaa weyi ɛsɩɣ-ŋ tʋmɩyɛ yɔ, ŋpɩzɩɣ nɛ ŋtiyini-ɖʋ takayaɣ nɛ ŋpɔzɩ se ɖɩlɩzɩ tɔm ndʋ yaa wonuu ŋgʋ yaa ɖitaayele nɛ nɔɔyʋ tɩlɩ-kʋ.']

['Pɩwɛɛ se pama takayaɣ nɛ petiyini ordinatɛɛrɩ yɔɔ.']

['DMCA paɣtʋ pɔzʋʋ se ye ŋnawa se nɔɔyʋ tɩma takayaɣ nakɛyɛ yɔ, ŋma tɔm tʋnɛ: (1) takayaɣ ŋga ŋnawa se nɔɔyʋ tɩma-kɛ yɔ kɔ-yɔɔ tɔm; (2) takayaɣ ŋga kɔ-yɔɔ pamawa se nɔɔyʋ tɩma takayaɣ nakɛyɛ yɔ kɔ-yɔɔ tɔm nɛ tɔm ndʋ tɩsɩɣnɩ-ɖʋ se ɖɩtɩlɩ ɖenɖe ŋnaɣ takayaɣ ŋga yɔ; (3) ña-hɩɖɛ, kaŋgalaafu mayaɣ nɛ intɛrnɛɛtɩ mayaɣ; (4) ŋyɔɔdɩ kpayɩ se ŋwɛnɩ tisuu se takayaɣ ŋga ŋnawa se nɔɔyʋ tɩma-kɛ yɔ, pɩtɩkɛ weyi ɛtɩnɩ takayaɣ ŋga yɔ ɛ-maɣmaɣ ɛlɩzɩnɩ-kɛ, yaa ɛ-tʋmlaɖʋ nɔɔyʋ lɩzɩnɩ-kɛ, yaa se paɣtʋ natʋyʋ ɛɛhaɣ nʋmɔʋ se palabɩnɩ-kɛ tʋmɩyɛ.']

['(5) Ye ŋlabɩ mbʋ yɔ, ŋpɩzɩɣ nɛ ŋcɛtɩnɩ ñɔ-tɔm yɔɔ nɛ ŋyɔɔdɩ se tɔm ndʋ pama takayaɣ ŋga ka-taa yɔ tɩkɛ toovenim nɛ ŋwɛnɩ waɖɛ se ŋlʋ nɛ ŋwa mba payʋsʋʋ se pɛwɛɛkɩ ña-takayaɣ yɔ.']

['Nɛ (6) ye nɔɔyʋ ɛtɩnɩ takayaɣ nakɛyɛ yɔɔ tɔm yɔ, pɩwɛɛ se ɛñɩɣ nesi takayaɣ ŋga kɔ-yɔɔ.']

['Ye patɩyɔɔdɩ tɔm ndʋ tɩ-tɩŋa yɔ, pɩpɩzɩɣ nɛ pɩkɔnɩ tɔm hʋʋ kaɖɛ.']

['Ɛyʋ weyi ŋkatɩɣ yɔ']

['Ye ŋwɛnɩ tɔm natʋyʋ yaa ŋñɩnɩɣ se ŋtasɩ tɔm natʋyʋ yɔ, ɖitendi-ŋ ma-ɖʋ takayaɣ.']

How to treat prostate cancer?

There are several treatment options available for prostate cancer, depending on the stage and aggressiveness of the cancer, as well as the patient's overall health and personal preferences.

Some common treatments include:

1. Active surveillance: This approach involves closely monitoring the cancer with regular checkups and tests, rather than immediately starting treatment.

It may be suitable for men with low-risk prostate cancer.

2. Surgery: A prostatectomy is a surgical procedure to remove the prostate gland.

It can be done through open surgery or laparoscopically (using small incisions and specialized tools).

3. Radiation therapy: This treatment uses high-energy radiation to kill cancer cells.

It can be delivered externally (from a machine outside the body) or internally (through implants placed near the tumor).

4. Hormone therapy: This treatment reduces the levels of male hormones (androgens) in the body, which can slow or stop the growth of prostate cancer.

It can be used alone or in combination with other treatments.

5. Chemotherapy: This treatment uses drugs to kill cancer cells.

It may be used for advanced prostate cancer that has spread to other parts of the body.

6. Immunotherapy: This treatment helps the immune system fight cancer.

It may be used for advanced prostate cancer that has not responded to other treatments.

7. Targeted therapy: This treatment targets specific genes or proteins that help cancer cells grow and survive.

It may be used for advanced prostate cancer that has not responded to other treatments.

8. Cryotherapy: This treatment uses extreme cold to freeze and kill cancer cells.

It may be used for early-stage prostate cancer or for cancer that has come back after other treatments.

9. High-intensity focused ultrasound (HIFU): This treatment uses high-frequency sound waves to heat and destroy cancer cells.

It may be used for early-stage prostate cancer or for cancer that has come back after other treatments.

10. Watchful waiting: This approach involves closely monitoring the cancer with regular checkups and tests, but not starting treatment unless symptoms appear or change.

It may be suitable for older men with slow-growing prostate cancer and other serious health conditions.

It is important to discuss all treatment options with a healthcare team to determine the best course of action for each individual case.

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