What causes Prostate cancer?

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Was verursacht Prostatakrebs?

De exacte oorzaak vaan prostaatkanker is neet bekind, mer versjèllende factore zien geïdentificeerd die 't risico op 't oontwikkele vaan de krenkde kinne vergroete.

Dit zien:

1. Laeftied: 't Risico op prostaatkanker kump mèt de laeftied veur.

2. Familiegesjiedenis: Manslui mèt 'n familiegesjiedenis vaan prostaatkanker, veural 'ne pa of 'ne broor mèt de krenkde, höbbe 'n hoeger risico.

3. Ras: Afro-Amerikaanse manslui höbbe 'n hoeger risico op prostaatkanker es manslui vaan aander rasse.

4. Dieet: 'n Dieet mèt väöl vet, veural dierlek vet, kin 't risico op prostaatkanker vergroete.

5. Vetsug: Euvergewich of vetsug kin 't risico op prostaatkanker vergroete.

6. Hormone: Hoege niveaus vaan testosteron en aander manneleke hormone kinne 't risico op prostaatkanker vergroete.

7. Ontsteking: Chronische ontsteking vaan de prostaat, wie prostatitis, kin 't risico op prostaatkanker vergroete.

8. Genetica: Bepaolde geërfde genetiese mutaties, wie die in de BRCA1 en BRCA2 gene, kinne 't risico op prostaatkanker vergroete.

't Is belangriek te merke dat 't höbbe vaan ein of mie vaan dees risicofactoren neet beteikent dat 'ne man zeker prostaatkanker zal kriege, en väöl manslui mèt prostaatkanker höbbe gein bekinde risicofactoren.

Daoneve weurt oonderzeuk gedoon um de oorsake vaan prostaatkanker beter te begriepe en extra risicofactoren te identificere.

['Verwiezinge']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Riihimäki M, Thomsen H, Brandt A, Sundquist J, Hemminki K: What do prostate cancer patients die of? Oncologist. 2011, 16 (2): 175-81.

Gilligan T: Social disparities and prostate cancer: mapping the gaps in our knowledge. Cancer Causes Control. 2005, 16 (1): 45-53.

Newschaffer CJ, Otani K, McDonald MK, Penberthy LT: Causes of death in elderly prostate cancer patients and in a comparison nonprostate cancer cohort. J Natl Cancer Inst. 2000, 92 (8): 613-21.

Frydenberg M, Wijesinha S: Diagnosing prostate cancer - what GPs need to know. Aust Fam Physician. 2007, 36 (5): 345-7.

Shimodaira K, Nakashima J, Nakagami Y, Hirasawa Y, Hashimoto T, Satake N, Gondo T, Namiki K, Ohori M, Ohno Y: Prognostic Value of Platelet Counts in Patients with Metastatic Prostate Cancer Treated with Endocrine Therapy. Urol J. 2020, 17 (1): 42-49.

Martínez-Salamanca JI, Ballesteros CM, Carballido Rodríguez J: [Epidemiological fundamentals of clinically localized prostate cancer]. Arch Esp Urol. 2011, 64 (8): 703-10.

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What causes prostate cancer?

The exact cause of prostate cancer is not known, but several factors have been identified that may increase the risk of developing the disease.

These include:

1. Age: The risk of prostate cancer increases with age, with most cases occurring in men over the age of 65.

2. Family history: Men with a family history of prostate cancer, particularly a father or brother with the disease, are at a higher risk.

3. Race: African American men have a higher risk of developing prostate cancer than men of other races.

4. Diet: A diet high in fat, particularly animal fat, may increase the risk of prostate cancer.

5. Obesity: Being overweight or obese may increase the risk of developing prostate cancer.

6. Hormones: High levels of testosterone and other male hormones may increase the risk of prostate cancer.

7. Inflammation: Chronic inflammation of the prostate, such as prostatitis, may increase the risk of prostate cancer.

8. Genetics: Certain inherited genetic mutations, such as those in the BRCA1 and BRCA2 genes, may increase the risk of prostate cancer.

It is important to note that having one or more of these risk factors does not mean that a man will definitely develop prostate cancer, and many men with prostate cancer have no known risk factors.

Additionally, research is ongoing to better understand the causes of prostate cancer and identify additional risk factors.

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