De pathofysiologie vaan prostaatkanker verwies nao de oonderligkende mechanismes en percesse die tot de oontwikkeling en progressie vaan de krenkde leije.
Prostaatkanker is 'n kwaadaardige tumor die ontsteit oet de celle vaan de prostaatklier, 'n klein, walnootvörmig orgaan oonder de blaos bij manslui.
De prostaatklier produceert zaodvloeistof, die zaodcelle voed en transporteert.
De exacte oorzaak vaan prostaatkanker is neet gans begriepelek, meh 't is bekind tot versjèllende factore 't risico op 't oontwikkele vaan de krenkde vergroete.
Dit zien oonder aandere leeftied, femiliegesjiedenis, ras en bepaolde genetische mutaties.
Prostaatkanker kump dèkser veur bij awwere manslui, de mieste gevalle zien vaan manslui euver de 65.
Daoneve höbbe manslui mèt 'n familiegesjiedenis vaan prostaatkanker 'n hoeger risico, zoewie Afro-Amerikaanse manslui en manslui vaan Caribische aofkoms.
De pathofysiologie vaan prostaatkanker behels de oonbeheerste greuj en deiling vaan celle binne de prostaatklier.
Dit kin veurkoume door genetische mutaties die leije tot de euverexpressie vaan bepaolde greujfactoren of de inactivering vaan tumor suppressor gene.
Dees mutaties kinne resultere in de oonreglementeerde greuj vaan celle, wat leijt tot de vörming vaan 'n tumor.
Es de tumor greujt, kin 't in de buurt ligkende weefsels en organe binnedringe, wie de blaos, rectum en naobieligkende lymfekliere.
In sommege gevalle kinne kankercelle losbreke vaan de primaire tumor en ziech verspreie nao aander deile vaan 't lief via de bloodbaan of 't lymfesysteem, 'n proces wat bekind steit es metastase.
Es de kanker zich oets verspreid haet, is 't lestiger te behandele.
Prostaatkanker kin ouch weure beïnvlood door hormonale factore, veural 't androgeen hormoon testosteron.
Testosteron kin de greuj vaan prostaatkankercelle stimulere en väöl behandelinge veur prostaatkanker zien bedoeld um 't niveau vaan dit hormoon te vermindere of de effecte te blokkere.
Samevattend geit 't euver de pathofysiologie vaan prostaatkanker.
't Begriepe vaan de oonderligkende mechanismes vaan de krenkde is cruciaal veur 't oontwikkele vaan effectieve behandelinge en 't verbetere vaan de oetkomste veur patiënte mèt prostaotkanker.
Zobniw CM, Causebrook A, Fong MK: Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer. Res Rep Urol. 2014, 6 (): 97-105.
Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.
Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.
Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.
Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.
Kotani K, Sekine Y, Ishikawa S, Ikpot IZ, Suzuki K, Remaley AT: High-density lipoprotein and prostate cancer: an overview. J Epidemiol. 2013, 23 (5): 313-9.
Jadvar H: Molecular imaging of prostate cancer: a concise synopsis. Mol Imaging. , 8 (2): 56-64.
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What is pathophysiology of prostate cancer?
The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.
Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.
The prostate gland produces seminal fluid, which nourishes and transports sperm.
The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.
These include age, family history, race, and certain genetic mutations.
Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.
Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.
The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.
This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.
These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.
As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.
In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.
Once the cancer has spread, it can be more difficult to treat.
Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.
Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.
In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.
Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.
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