L'Alzheimer l"è un disturb neurodegenerativ progressiv che l"afetta el cervel, causand perdita de memoria, declin cognitif e cambiament de comportament.
La causa precisa de la malatia de Alzheimer l"è minga ben capida, ma se pensa che la vegna de una combinaziun de fattur genetich, ambient e stil de vita.
Un quai fattur qe pœden contribuir al svilup de la malatia de Alzheimer i includen:
1. Genetica: Se g'ha identificà certi geni qe aumenten el ris'c de sviluppà la malatia de Alzheimer, en particolàr el gen de l'apolipoproteina E (APOE).
2. Età: El ris'c de sviluppà la malatia de Alzheimer aumenta cun l'età, e la magiur part di gent la vegn diagnosticada dopu i 65 agn.
3. Storia familiara: Avè una storia familiara de la malattia de Alzheimer pœu aumentà el ris'c de sviluppà la condizion.
4. Lesiun de la testa: Una storia de lesiun de la testa, suratüt quei che i pœden portà a la perdita de la coscienza, pœden aumentà el ris'c de la malatia de Alzheimer.
5. I fattur de ris'c cardiovascular: I condizion cuma la pressión alta, el colesterol alt e el diabete pœden aumentar el ris'c de sviluppà la malatia de Alzheimer.
6. I fattur del stil de vita: Un stil de vita sedentari, una dieta povera e una mancanza de stimol mental pœden aumentà el ris'c de la malatia de Alzheimer.
7. Inflamaziun: Una inflamaziun cronica in del cervel la pœl contribuir al svilup de la malatia de Alzheimer.
8. Stress ossidativ: Un squilibri intra la produziun di radicai liber e la capacità del corp de desintossicar-i pœden contribuir al svilup de la malatia de Alzheimer.
9. Le placche amiloidi e i grovigli neurofibrillari: L'accumulament de placche amiloidi e grovigli neurofibrillari ind el cervel l"è un segn de la malatia de Alzheimer, ma el roeul che i gh'hann ind el desvilup de la condizion l"è minga ben capii.
L'è important de tegnì cont che la causa de la malatia de Alzheimer l"è cumplessa e la coinvolge probabilment una combinazion de'sti fattur.
La ricerca l"è in progress per capì mej i mecanism sottostant e sviluppà di trattament eficaci per questa condizion devastanta.
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Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H: Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci. 1999, 249 Suppl 3 (): 14-22.
Kovacs GG: Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer? Prion. 2016, 10 (5): 369-376.
Cankurtaran M, Yavuz BB, Cankurtaran ES, Halil M, Ulger Z, Ariogul S: Risk factors and type of dementia: vascular or Alzheimer? Arch Gerontol Geriatr. , 47 (1): 25-34.
Mahami-Oskouei M, Hamidi F, Talebi M, Farhoudi M, Taheraghdam AA, Kazemi T, Sadeghi-Bazargani H, Fallah E: Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? Parasitol Res. 2016, 115 (8): 3169-74.
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What causes alzheimer?
Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects the brain, causing memory loss, cognitive decline, and behavioral changes.
The exact cause of Alzheimer's disease is not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors.
Some of the factors that may contribute to the development of Alzheimer's disease include:
1. Genetics: Certain genes have been identified that increase the risk of developing Alzheimer's disease, particularly the apolipoprotein E (APOE) gene.
2. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.
3. Family history: Having a family history of Alzheimer's disease may increase the risk of developing the condition.
4. Head injuries: A history of head injuries, particularly those that result in loss of consciousness, may increase the risk of Alzheimer's disease.
5. Cardiovascular risk factors: Conditions such as high blood pressure, high cholesterol, and diabetes may increase the risk of developing Alzheimer's disease.
6. Lifestyle factors: A sedentary lifestyle, poor diet, and lack of mental stimulation may increase the risk of Alzheimer's disease.
7. Inflammation: Chronic inflammation in the brain may contribute to the development of Alzheimer's disease.
8. Oxidative stress: An imbalance between the production of free radicals and the body's ability to detoxify them may contribute to the development of Alzheimer's disease.
9. Amyloid plaques and neurofibrillary tangles: The accumulation of amyloid plaques and neurofibrillary tangles in the brain is a hallmark of Alzheimer's disease, but the role they play in the development of the condition is not fully understood.
It is important to note that the cause of Alzheimer's disease is complex and likely involves a combination of these factors.
Research is ongoing to better understand the underlying mechanisms and develop effective treatments for this devastating condition.
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