El cancher de colon, cognossüü anca cuma cancher coloretal, l"è causad de la cressita minga controllada de cellule anormali in del colon o del retto.
La causa precisa del cancer del colon l"è minga cognossuda, ma vari fattur pœden aumentà el ris'c de sviluppà la malatia.
Chesti i cumprenden:
1. Età: El ris'c de cancer del colon aumenta cun l'età, e la magiur part di cas se tröven in di persun de püssè de 50 agn.
2. Storia familiara: Una storia personal o familiara de cancher o polip del colon aumenta el ris'c de sviluppà la malattia.
3. Sindromi ereditai: certi sindromi genetich ereditai, cuma la poliposi adenomatosa familiara (FAP) e el cancher del colon-retal ereditaa senza poliposi (HNPCC), pœden aumentar el ris'c de cancher del colon.
4. I fattur del stil de vita: Una dieta rica de carni rosse e processade, obesità, fumà e consum eccessiv de alcol pœden aumentà el ris'c de cancer del colon.
5. Malattia infiammatoria intestinale: Malattie infiammatorie intestinali a lungh temp, cuma la colite ulcerosa e la malattia de Crohn, pœden aumentà el ris'c de cancer del colon.
6. Diabete de tipo 2: I persunagg cun diabete de tipo 2 g'han un ris'c püsee grand de sviluppà el cancher de colon.
7. Radioterapia: La radioterapia per olter cancher in de l'addome pœl aumentar el ris'c de cancher de colon.
8. Razza: I afroamerican g'han un ris'c püsee alt de sviluppà el cancher al colon che i olter razzi.
L'è important de tegnì cont che avegh vun o plu de'sti fattur de ris'c el vœl minga dì che una persona la svilupparà el cancher de colon, e una quai persona che svilupparà el cancher de colon la pœl minga avegh di fattur de ris'c cognossuu.
I control regolar e la rilevazion a temp indree pœden jutar a prevenir el cancher de colon o a rilevàll a un stadi indree quand l"è pussee curabil.
McWhirter JE, Todd LE, Hoffman-Goetz L: Beliefs about causes of colon cancer by English-as-a-Second-Language Chinese immigrant women to Canada. J Cancer Educ. 2011, 26 (4): 734-9.
Gamble JF: Asbestos and colon cancer: a weight-of-the-evidence review. Environ Health Perspect. 1994, 102 (12): 1038-50.
Ashish S, Raj M: Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden. Cureus. 2022, 14 (3): e22894.
Xu W, Zhang Y, Chen L, Qiu F, Zhang B, Wu L, Peng Z, Tang H: Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget. 2017, 8 (42): 71954-71964.
Wang J, Wu HF, Shen W, Xu DY, Ruan TY, Tao GQ, Lu PH: SRPK2 promotes the growth and migration of the colon cancer cells. Gene. 2016, 586 (1): 41-7.
Taketo MM, Edelmann W: Mouse models of colon cancer. Gastroenterology. 2009, 136 (3): 780-98.
Slattery ML, Kerber RA: The impact of family history of colon cancer on survival after diagnosis with colon cancer. Int J Epidemiol. 1995, 24 (5): 888-96.
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What causes colon cancer?
Colon cancer, also known as colorectal cancer, is caused by the uncontrolled growth of abnormal cells in the colon or rectum.
The exact cause of colon cancer is not known, but several factors can increase the risk of developing the disease.
These include:
1. Age: The risk of colon cancer increases with age, with most cases occurring in people over the age of 50.
2. Family history: A personal or family history of colon cancer or polyps increases the risk of developing the disease.
3. Inherited syndromes: Certain inherited genetic syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), can increase the risk of colon cancer.
4. Lifestyle factors: A diet high in red and processed meats, obesity, smoking, and excessive alcohol consumption can increase the risk of colon cancer.
5. Inflammatory bowel disease: Long-term inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, can increase the risk of colon cancer.
6. Type 2 diabetes: People with type 2 diabetes have an increased risk of developing colon cancer.
7. Radiation therapy: Radiation therapy for other cancers in the abdomen can increase the risk of colon cancer.
8. Race: African Americans have a higher risk of developing colon cancer than other races.
It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop colon cancer, and some people who develop colon cancer may not have any known risk factors.
Regular screening and early detection can help prevent colon cancer or detect it at an early stage when it is most treatable.
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