La fisiopatologia del tumur de mamm la se riferiss ai cambiament anormai ind i process e i mecanism fisiologich normal qe se verifican ind el desvilup e la progression del tumur de mamm.
L'implica el stüdi di mecanism biològich e molecolar che g'han de fà cun la cressita e la diffusiun incontrolada di cellule cancerose in del tesütu del mamm.
Chesto g'ha dent i fattur genetich, epigenetich e ambientài che cuntribuissen a l'inizi, la promoziun e la progression del cancher de mamm.
Un quai di cambiament fisiopatologich principai ind el cancher de mamm includen:
1. Mutazion genetich: Mutazion in certi geni, cuma BRCA1 e BRCA2, pœden aumentà el ris'c de sviluppà el cancher al sen.
Cheste mutaziun pœden vesser eredità o acquistade durant la vita de una persona.
2. squilibri ormonai: I ormonai, in particolar l'estrogen, pœden vesser un element in del svilup e la cressida del cancher al sen.
Un squilibri in di livèll ormonai o l'esposiziun a un ecess de estrogeni pœden aumentà el ris'c de cancer de mamm.
3. Inflamaziun: L'inflamaziun cronica ind el tessud del mamm pœu contribuir al svilup del cancer del mamm favorind la cressida e la sopravvivenza di cellule cancerose.
4. El microambient del tumur: L'ambient che circonda el tumur, compresa la matris extracellular, i cellule immunitarie e i vas de sangh, pœden influenzar la cressida e la diffusion del tumur de mamm.
5. Metastasi: El cancher de mamm el se pœl spantegar in di olter part del corp travers el sistema linfatich o el flus sanguigno, condusend a la formazion de tumors secondari in di organ distant.
Capir la fisiopatologia del cancer de mamm l"è crucial per sviluppà di strategie de prevenzion, rilevazion e cura prest.
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Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
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What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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