Uortikareja, kū parosti sauc par nātreni, ir uodys slimeiba, kurai rakstureiga kosšonuos, pacāluse, sorkonys plankumu (izšyvumu) izaruodeišona uodā.
Urtirejis patofiziologejā ir īsaisteita histamina i cytu uorstejūšu faktoru izadaleišona nu mastšyunom, kas ir uodā i cytuos audūs asūšys imunsyunys.
Akūtā nātrenejā histamina i cytu mediatoru izadaleišonu roda alerģiska reakceja iz konkretu alergenu, par pīmāru, puortyku, medikamentus voi kukaiņu kodumu.
Tys izraisa mastšyunu degranulaceju, atbreivojūt histaminu i cytus mediatorus, kas izraisa asinsvadu iztakumu, veidojūt teļšonūs.
Hroniskajā nātreneibā bīži viņ nav zynoma īmesļa, tok teik skaiteits, ka tei ir saisteita ar autoimunu mehanismu.
Itymā gadīnī kermini ražoj autoantikys, kuru mierkis ir augsta afinitata IgE receptori (FcεRI) iz mastu šyunom, kas nūvad pi tūs aktivacejis i histamina i cytu mediatoru izadaleišonys.
Gon akūtā, gon hroniskuos nātrenejā histamina i cytu mediatoru izadaleišona roda raksturiskus niezis, apsārtuma i tūs tūsku simptomus.
Parostai izuorsteišona ir antihistaminu izmontuošona, kab blokeitu histamina ītekmi i samazynuotu simptomus.
Smagūs gadīņūs slimeibu var kontrolēt, izmontojūt cytus medikamentus, par pīmāru, kortikosteroidus voi omalizumabu.
Wahlgren CF: Pathophysiology of itching in urticaria and atopic dermatitis. Allergy. 1992, 47 (2 Pt 1): 65-75.
Raap U, Liekenbröcker T, Wieczorek D, Kapp A, Wedi B: [New therapeutic strategies for the different subtypes of urticaria]. Hautarzt. 2004, 55 (4): 361-6.
[Recommendations for the diagnosis and treatment of urticaria in children]. Arch Argent Pediatr. 2021, 119 (2): S54-S66.
Brzoza Z, Grzeszczak W, Rogala B, Trautsolt W, Moczulski D: Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Allergol Immunopathol (Madr). , 42 (4): 302-6.
Sweeney TM, Dexter WW: Cholinergic urticaria in a jogger: ruling out exercise-induced anaphylaxis. Phys Sportsmed. 2003, 31 (6): 32-6.
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What is pathophysiology of urticaria?
Urticaria, commonly known as hives, is a skin condition characterized by the appearance of itchy, raised, red welts (wheals) on the skin.
The pathophysiology of urticaria involves the release of histamine and other inflammatory mediators from mast cells, which are immune cells found in the skin and other tissues.
In acute urticaria, the release of histamine and other mediators is triggered by an allergic reaction to a specific allergen, such as food, medication, or insect sting.
This causes the mast cells to degranulate, releasing histamine and other mediators that cause blood vessels to become leaky, leading to the formation of wheals.
In chronic urticaria, the cause is often unknown, but it is thought to be related to an autoimmune mechanism.
In this case, the body produces autoantibodies that target the high-affinity IgE receptor (FcεRI) on mast cells, leading to their activation and the release of histamine and other mediators.
In both acute and chronic urticaria, the release of histamine and other mediators leads to the characteristic symptoms of itching, redness, and swelling.
Treatment typically involves the use of antihistamines to block the effects of histamine and reduce symptoms.
In severe cases, other medications such as corticosteroids or omalizumab may be used to control the condition.
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