Pumpui cancer natna (pathophysiology) chu eng nge ni?
Pumpui cancer natna (pathophysiology of lung cancer) tih chu pumpui cancer lo chhuahna leh a lo pun chhoh zêlna kawnga taksa hnathawh dân pangngai leh a kalhmang danglamna a ni.
Pumpui cancer hi natna khirh tak a ni a, chu chu pumpui chhûnga cell ṭha lo lo ṭhang leh inṭhen darh dân aṭanga lo awm a ni.
Chûng cellte chuan pum chhûngah cancer a siam thei a, taksa pêng dangah a darh a, chu chuan natna chi hrang hrang leh harsatna a thlen thei a ni.
Pumpui cancer natna (pathophysiology) hian thil tam tak a keng tel a, chungte chu genetic mutation te, environmental factors te, leh nunphung thlan te a ni.
Genetic mutation chu DNA-a awm a ni a, chu chuan cell ṭhang chakna leh inṭhen chakna chu a thunun thei lo.
Chûng inthlâk danglamna chu rochun emaw, neih emaw a ni thei a, meizial khu, radon, asbestos, leh boruak bawlhhlawhna ang chi cancer thlentu thilte avânga lo awm a ni thei bawk.
Pumpui cancer hi chi hnih-small cell lung cancer (SCLC) leh non-small cell lung cancer (NSCLC) -ah then theih a ni a. NSCLC hi chi thumah then a ni a: adenocarcinoma, squamous cell carcinoma leh large cell carcinoma te an ni.
He lung cancer chi hrang hrangte hi genetic mutation hrang hrang an neih avângin, enkawl dân pawh a inang lo va, an natna leh an natna inkaichhawn dân pawh a inang lo thei a ni.
Pumpui cancer natna chu cancer cell leh a vêltu tissue, immune system te inkûngkaihna aṭangin a lo awm a ni.
Cancer cells-te chuan immune system chu tlânchhiain, an pung chak theiin, an darh nasa thei hle a ni.
Chu bâkah, tumor microenvironment chuan cancer cell-te tân boruak ṭha a siam avângin tumor ṭhan chakna leh metastasis a tichak thei bawk.
Pumpui cancer natna hi thil khirh tak leh danglam thei tak a ni a, damlote enkawlna ṭha leh damdawi ṭha zâwk siam chhuah nâna a awm dân hriat thiam tumin zir mite chuan an bei reng a ni.
Li Z, Qian Y, Li W, Liu L, Yu L, Liu X, Wu G, Wang Y, Luo W, Fang F, Liu Y, Song F, Cai Z, Chen W, Huang W: Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020, 23 (8): 101411.
Nurwidya F, Syahruddin E, Yunus F: Pain management in lung cancer. Adv Respir Med. 2016, 84 (6): 331-336.
Khan KA, Kennedy MP, Moore E, Crush L, Prendeville S, Maher MM, Burke L, Henry MT: Radiological characteristics, histological features and clinical outcomes of lung cancer patients with coexistent idiopathic pulmonary fibrosis. Lung. 2015, 193 (1): 71-7.
Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A: Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. Int J Mol Sci. 2022, 23 (21): .
Lee D, Kim Y, Chung C: Scientific Validation and Clinical Application of Lung Cancer Organoids. Cells. 2021, 10 (11): .
Mucchietto V, Crespi A, Fasoli F, Clementi F, Gotti C: Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des. 2016, 22 (14): 2160-9.
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What is pathophysiology of lung cancer?
The pathophysiology of lung cancer refers to the changes in the normal physiological processes and mechanisms that occur in the development and progression of lung cancer.
Lung cancer is a complex disease that arises from the uncontrolled growth and division of abnormal cells in the lungs.
These cells can form tumors and spread to other parts of the body, leading to various symptoms and complications.
The pathophysiology of lung cancer involves several factors, including genetic mutations, environmental factors, and lifestyle choices.
Genetic mutations can occur in the DNA of lung cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can be caused by exposure to carcinogens, such as tobacco smoke, radon, asbestos, and air pollution.
Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is further divided into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.
The pathophysiology of these types of lung cancer can differ, as they have different genetic mutations and respond differently to treatment.
The pathophysiology of lung cancer also involves the interaction between cancer cells and the surrounding tissue, including the immune system.
Cancer cells can evade the immune system, allowing them to grow and spread unchecked.
Additionally, the tumor microenvironment can promote tumor growth and metastasis by providing a supportive environment for cancer cells.
The pathophysiology of lung cancer is a complex and dynamic process, and researchers are continuously working to better understand the underlying mechanisms to develop more effective treatments and improve patient outcomes.
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