Ko te urticaria, e mōhiotia nuitia ana ko te hives, he mate kiri e kitea ana e te āhua o te kōputaputa, te whakaara, te whero whero (wheals) i runga i te kiri.
Ko te pathophysiology o te urticaria e pa ana ki te tuku histamine me etahi atu kaiwhakawhitinga mumura mai i nga pūtau mast, he pūtau ārai mate e kitea ana i te kiri me etahi atu kiko.
I te urticaria kino, ko te tuku o te histamine me etahi atu kaitakawaenga ka whakaohohia e te urupare mate ki tetahi mate motuhake, penei i te kai, te rongoa, te ngau ngārara ranei.
Mā tēnei e whakakorea ai ngā pūtau mast, e tuku ana i te histamine me ētahi atu takawaenga e meinga ai ngā oko toto kia rere, e ahu ana ki te hanganga o ngā wira.
I te urticaria ma'i, kaore i te mohiotia te take, engari e whakaarohia ana he hononga ki te tikanga autoimmune.
I tēnei take, ka whakaputa te tinana i ngā autoantibodies e aro ana ki te kaiwhiwhi IgE-affinity tiketike (FcεRI) i runga i ngā pūtau mast, e ahu ana ki te whakahohe me te tuku i te histamine me ētahi atu takawaenga.
I roto i te urticaria kino me te roa, ko te tuku o te histamine me etahi atu kaitakawaenga ka arahi ki nga tohu tohu o te hakihaki, te whero, me te pupuhi.
Ko te tikanga ko te maimoatanga ko te whakamahi i nga antihistamines hei aukati i nga paanga o te histamine me te whakaiti i nga tohu.
I ngā take taumaha, ka whakamahia pea ētahi atu rongoā pēnei i te corticosteroids, te omalizumab rānei hei whakahaere i te mate.
Wahlgren CF: Pathophysiology of itching in urticaria and atopic dermatitis. Allergy. 1992, 47 (2 Pt 1): 65-75.
Raap U, Liekenbröcker T, Wieczorek D, Kapp A, Wedi B: [New therapeutic strategies for the different subtypes of urticaria]. Hautarzt. 2004, 55 (4): 361-6.
[Recommendations for the diagnosis and treatment of urticaria in children]. Arch Argent Pediatr. 2021, 119 (2): S54-S66.
Brzoza Z, Grzeszczak W, Rogala B, Trautsolt W, Moczulski D: Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Allergol Immunopathol (Madr). , 42 (4): 302-6.
Sweeney TM, Dexter WW: Cholinergic urticaria in a jogger: ruling out exercise-induced anaphylaxis. Phys Sportsmed. 2003, 31 (6): 32-6.
['Whakakahoretanga: hauora']
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["Me tuku ngā whakamōhiotanga ā-tuhi mā te īmēra (tirohia te wāhanga 'Whakapā' mō te wāhitau īmēra). "]
['E hiahiatia ana e te DMCA kia whakaurua ki tō whakamōhiotanga mō te whakawātea mana pupuri i ngā mōhiohio e whai ake nei: (1) whakaahuatanga o te mahi mana pupuri e pā ana ki te whakawātea e whakapaetia ana; (2) whakaahuatanga o te ihirangi e whakapaetia ana e takahi ana me ngā mōhiohio e tika ana kia taea ai e mātou te kimi i te ihirangi; (3) mōhiohio whakapā mōu, tae atu ki tō wāhitau, tau waea me tō wāhitau īmēra; (4) he tauākī nāu e whakapono pono ana koe kāore te ihirangi i te āhua e amuamutia ana i whakamanahia e te kaipupuri mana pupuri, e tana māngai rānei, e te whakahaerenga rānei o tētahi ture; ']
['(5) he tauākī nāu i haina, i raro i te whiu o te whakapae teka, e tika ana ngā mōhiohio i roto i te whakamōhiotanga, ā, kei a koe te mana ki te whakatinana i ngā mana pupuri e kīia ana kua takahia;']
['me te (6) he waitohu ā-tinana, ā-rorohiko rānei a te kaipupuri mana pupuri, a tētahi tangata rānei kua whakamanahia ki te mahi mō te kaipupuri mana pupuri. ']
['Ki te kore e whakaurua ngā mōhiohio katoa i runga ake nei, ka whakaroa pea te tukatuka o tō amuamu.']
['Whakapā']
['Tena koa tukuna mai he imeera ki a maatau me tetahi patai / whakaaro.']
What is pathophysiology of urticaria?
Urticaria, commonly known as hives, is a skin condition characterized by the appearance of itchy, raised, red welts (wheals) on the skin.
The pathophysiology of urticaria involves the release of histamine and other inflammatory mediators from mast cells, which are immune cells found in the skin and other tissues.
In acute urticaria, the release of histamine and other mediators is triggered by an allergic reaction to a specific allergen, such as food, medication, or insect sting.
This causes the mast cells to degranulate, releasing histamine and other mediators that cause blood vessels to become leaky, leading to the formation of wheals.
In chronic urticaria, the cause is often unknown, but it is thought to be related to an autoimmune mechanism.
In this case, the body produces autoantibodies that target the high-affinity IgE receptor (FcεRI) on mast cells, leading to their activation and the release of histamine and other mediators.
In both acute and chronic urticaria, the release of histamine and other mediators leads to the characteristic symptoms of itching, redness, and swelling.
Treatment typically involves the use of antihistamines to block the effects of histamine and reduce symptoms.
In severe cases, other medications such as corticosteroids or omalizumab may be used to control the condition.
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