What causes Colon cancer?

['Liɛŋ wargak ɛmɛ']

Ɛŋu mi jak juey colon cancer kä tuɔɔk?

Kɔntar kɔlön, mi̱ ŋa̱ckɛ bä cie kɔlörɛktal kanthɛr, ɛ mi̱ la bëë kä mi̱ /ca luäŋ kɛ kuën kä thëlli̱ tin /ci̱ rɔ̱ laa luäŋ kɛ kuën rɛy kɔlön kiɛ rektum.

Kä min jak juey kä colon cancer /ca ŋäc, duŋni̱ ɣöö tëë kɛ ti̱ ŋuan ti̱ de rɔ̱ rep kɛ juey.

Ti̱ti̱ cu määni̱:

1. Rɛy runi̱: Rɛy riɛk in tekɛ raan kɛ juey kanthɛr in tä rɛy puɔ̱ɔ̱nydɛ laa rɔ laa repɛ kɛ runi̱ tin laa raan runkɛ wɔ̱ kɛ, kä nɛy tin laa juey kanthɛr laa jekɛ jɛ laa kɛn nɛy tin ci̱ runkiɛn räth kä 50.

2.Gua̱n duel: Mi ci raan rɔ tuɔm kɛ juey thith kiɛ juey thith ɛ ji̱ dhɔru derɛ juey ɛmɔ jakä di̱t.

3. Kɛn jua̱th tin laa ji̱ɛckɛ: Kɛn jua̱th tin laa ji̱ɛckɛ, ce̱tkɛ familial adenomatous polyposis (FAP) kɛnɛ jua̱th tin laa ji̱ɛckɛ tin laa no̱o̱ŋkɛ kanthɛr rɛy puɔ̱ɔ̱ny ran (HNPCC), laa kɛ laa jakɛ kä laa tekɛ juey kanthɛr rɛy puɔ̱ɔ̱ny ran.

4.Thiɛl mi̱ gɔaa kɛ kui̱ teekä: Mi̱i̱th ti̱ ŋuan ti̱ tä kɛ ri̱ŋ mi̱i̱th mi̱ ci̱ rɔ̱ luäŋ kɛ mi̱eth, mi̱i̱th ti̱ di̱t, ma̱th kɛ wal, kɛnɛ ma̱th kɛ kɔaŋ ɛlɔ̱ŋ derɛ juey kanthɛr in te rɛy puɔ̱ɔ̱ny jakä di̱t.

5. Kɛn jua̱th tin laa jakɛ tuɔm kä bɛc: Kɛn jua̱th tin laa jakɛ tuɔm kä bɛc tin laa te thi̱n kɛ gua̱a̱th mi̱ bäär, ce̱tkɛ ulcerative colitis kɛnɛ Crohn's disease, laa jakɛ tuɔm kä bɛc kä bɛc kä colon cancer.

6. Di̱ba̱ti̱th in rɛwdɛ: Nɛy tin tekɛ di̱ba̱ti̱th in rɛwdɛ tekɛ riɛk mi̱ di̱i̱t kɛ ɣöö bi̱ kɛ tekɛ kanthɛr mi̱ di̱i̱t.

7. Rɛdi̱e̱tɛrapi̱: Rɛdi̱e̱tɛrapi̱ kɛ kui̱ kanthɛri̱ kɔ̱kiɛn rɛy puɔ̱nydɛ derɛ riɛk kä kanthɛr in di̱i̱t rep.

8. Rɛydɛ: Ji̱ Africa tin la ji̱ America tekɛ riɛk mi̱ di̱i̱t ɛlɔ̱ŋ kɛ ɣöö bi̱ kɛ tekɛ juey kanthɛr mi̱ di̱i̱t kä nɛy tin kɔ̱kiɛn.

Jɛn ɛ mi̱ di̱i̱t ɛn ɣöö ba ŋa̱c ɛn ɣöö mi̱ tekɛ kɛl kiɛ ti̱ ŋuan kä tin laa nööŋkɛ rik /cɛ lot ni̱ ɣöö bi̱ raan tekɛ kanthɛr kɔlɔn, kä tha̱a̱ŋ nath tin laa tekɛ kanthɛr kɔlɔn dɔ̱ŋ /thiɛlɛ mi̱ laa nööŋkɛ rik.

Guäc pua̱a̱ny gua̱thni̱ diaal kɛnɛ jiekdɛ kɛ gua̱a̱thdɛ derɛ luäk kɛ ga̱ŋ kä kancer pua̱a̱ny kiɛ derɛ jɛ jek kɛ gua̱a̱thdɛ mëë ŋotdɛ kɛ tuɔk mi̱ derɛ luäk.

['Kuënɛ']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

McWhirter JE, Todd LE, Hoffman-Goetz L: Beliefs about causes of colon cancer by English-as-a-Second-Language Chinese immigrant women to Canada. J Cancer Educ. 2011, 26 (4): 734-9.

Gamble JF: Asbestos and colon cancer: a weight-of-the-evidence review. Environ Health Perspect. 1994, 102 (12): 1038-50.

Ashish S, Raj M: Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden. Cureus. 2022, 14 (3): e22894.

Xu W, Zhang Y, Chen L, Qiu F, Zhang B, Wu L, Peng Z, Tang H: Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget. 2017, 8 (42): 71954-71964.

Wang J, Wu HF, Shen W, Xu DY, Ruan TY, Tao GQ, Lu PH: SRPK2 promotes the growth and migration of the colon cancer cells. Gene. 2016, 586 (1): 41-7.

Taketo MM, Edelmann W: Mouse models of colon cancer. Gastroenterology. 2009, 136 (3): 780-98.

Slattery ML, Kerber RA: The impact of family history of colon cancer on survival after diagnosis with colon cancer. Int J Epidemiol. 1995, 24 (5): 888-96.

['Lät kɛ kui̱i̱ jua̱thni̱']

['Ɛn wɛbthaay ɛmɛ ca la̱th lät kɛ kui̱ ŋi̱i̱cä kɛnɛ läri kä /cɛ lot ni ɣöö ba ji̱ moc kɛ luäk ki̱mä kiɛ lät ti̱ gööl.']

['Lät kɛ läri tin ca ŋun /ca kɛ bi̱ lät kɛ ɣöö ba jua̱th jek kiɛ ba kɛ ciɛŋ, kä nɛy tin görkɛ luäk ki̱mädiɛn kärɔ̱ ba kɛ thiec kä ki̱m mi̱ tekɛ luäk ki̱mä.']

['Guic ɛ gɔaa ɛn ɣöö ɛn neural net min jak luɔc kä thie̱cni̱, /cɛ thuɔ̱k ɛlɔ̱ŋ mi̱ ci̱ ben kä nämbäri̱ tin te thi̱n. cetkɛ pek nath tin ca jek kɛ juey mi̱ rɛlrɔ.']

['Ni ciaŋ go̱ri ruac kä ki̱mdu kiɛ ram in kɔ̱ŋ mi ŋäc luäk pua̱a̱ny kɛ kui̱ jua̱thdu. /Cu ruac ki̱mdu car kiɛ jääny kɛ go̱ri kɛ kui̱ kä mi ci kuɛn kä wɛbthaay ɛmɛ. Mi caari jɛ ɛn ɣöö deri tekɛ juey mi go̱o̱ri luäk, cɔl 911 kiɛ wër guäth in thia̱k kɛ ji kɛ pɛ̈th. /Thilɛ maar kam ki̱m kɛnɛ juey mi bi̱ tuɔɔk kɛ kui̱ kä wɛbthaay ɛmɛ kiɛ la̱tdɛ. /Ci̱ BioMedLib kiɛ la̱a̱tkɛ, kiɛ ram in gɔ̱a̱r kɛ kui̱ kä wɛbthaay ɛmɛ, bi̱ ruac lat, kiɛ bi̱ ruac lat, kɛ kui̱ läri tin ca ka̱m raar rɛydɛ kiɛ la̱tdɛ.']

['Lät kɛ: ŋuɔ̱t']

['Ɛn Digital Millennium Copyright Act 1998, 17 U.S.C. § 512 (ɛ DMCA) ɛ ŋuɔ̱t mi̱ ŋun ji̱ cuŋni̱ tin ŋääth kɛn ɣöö ci̱ ŋɔaani̱ tin te kä intɛrnɛt ŋuɔ̱tkiɛn to̱l kɛ kui̱ ŋuɔ̱tni̱ cuŋni̱ tin te kä U.S.']

['Mi ca ji̱ ŋäth kɛ thuɔ̱k ɛn ɣöö tëëkɛ mi̱ ca gɔ̱r kiɛ mi̱ ca ka̱m ji̱ rɛy wɛbthaayäda kiɛ lät tin kɔ̱ŋ tin ci̱ ŋuɔ̱t tin ca gɔ̱r ya̱r, ji̱n (kiɛ ram in lät kɛ kui̱du) deri̱ kɔ jäk kä warɛgak mi̱ bi̱ ji̱ thiec ɛn ɣöö ba min ca gɔ̱r kiɛ min ca gɔ̱r woc, kiɛ ba duɔ̱ɔ̱r la̱t kɛ ɣöö bi̱ ji̱ cop thi̱n.']

['Kɛn läri̱ ba kɛ jäk kɛ wargak ɛ la i̱thtäm (guic ni̱ gua̱th in ci̱ i̱thtäm in ca gɔ̱r "Kɔntak" kɛ kui̱ i̱thtäm in ci̱ jäk).']

['DMCA go̱o̱rɛ ɣöö bi̱ ji̱n warɛgakdu lat kɛ kui̱ kä tin ca lar i̱ ci̱ ŋuɔ̱t gɛr kɛ kui̱i̱ ŋuɔ̱tni̱ gɔ̱rä mat thi̱n kɛ läär ti̱ti̱: (1) latdɛ kɛ kui̱i̱ la̱t in ca gɛr kɛ kui̱i̱ ŋuɔ̱tni̱ gɔ̱rä min ca lar i̱ ca gɛr; (2) latdɛ kɛ kui̱i̱ kä tin ca lar i̱ ci̱ ŋuɔ̱t gɛr kɛnɛ läär ti̱ ro̱ŋ kɛ ɣöö bi̱ kɔn kɛ jek; (3) läri̱ kɛ kui̱i̱ kä min dëë ji̱ luäk kɛ jek, amäni̱ ci̱ötdu, nämbärɛ kä tin ci̱ ji̱ luäk kɛ jek, kɛnɛ emaildu; (4) latdu kɛ ɣöö ci̱ ji̱n ɛ ŋa̱c ɛn ɣöö min ca gɔ̱r kɛ kui̱i̱ kä tin ca lar /ci̱kɛ bi̱ lät kɛ luäkdɛ ɛ gua̱n ŋuɔ̱tni̱ gɔ̱rä, kiɛ ɛ la̱tdɛ, kiɛ kɛ luäk ŋuɔ̱tni̱; ']

['(5) mi ci ji gɔr piny kɛ kuic kä ɣöö bi ji ruac kɛ thuɔ̱k, ɛn ɣöö läri tin ca gɔr ɛ thuɔ̱k kä te ji kɛ lua̱ŋ kɛ ɣöö bi yiöw tin ca gɔr piny tin ca lar ɛ ji̱n ka̱m raar;']

['kɛnɛ (6) mi̱ ca gɔ̱r piny ɛ gua̱n ŋuɔ̱tni̱ kiɛ ram mi̱ tekɛ lua̱ŋ kɛ lät kɛ kui̱dɛ.']

['Mi /kenɛ läri tin ca lat nhial diaal mat thi̱n dɔ̱ŋ derɛ ku lɛ wɔ̱ jɔ̱ɔ̱r kɛ lätni̱ kɛ kɛ.']

['Röm kɛ jɛ']

['Thiecɛ kɔ kɛ email kɛ thiecni kiɛ cär.']

What causes colon cancer?

Colon cancer, also known as colorectal cancer, is caused by the uncontrolled growth of abnormal cells in the colon or rectum.

The exact cause of colon cancer is not known, but several factors can increase the risk of developing the disease.

These include:

1. Age: The risk of colon cancer increases with age, with most cases occurring in people over the age of 50.

2. Family history: A personal or family history of colon cancer or polyps increases the risk of developing the disease.

3. Inherited syndromes: Certain inherited genetic syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), can increase the risk of colon cancer.

4. Lifestyle factors: A diet high in red and processed meats, obesity, smoking, and excessive alcohol consumption can increase the risk of colon cancer.

5. Inflammatory bowel disease: Long-term inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, can increase the risk of colon cancer.

6. Type 2 diabetes: People with type 2 diabetes have an increased risk of developing colon cancer.

7. Radiation therapy: Radiation therapy for other cancers in the abdomen can increase the risk of colon cancer.

8. Race: African Americans have a higher risk of developing colon cancer than other races.

It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop colon cancer, and some people who develop colon cancer may not have any known risk factors.

Regular screening and early detection can help prevent colon cancer or detect it at an early stage when it is most treatable.

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