Kä pathophysiology duŋ kancära colon lotdɛ ni̱ ta̱a̱ in tä kɛ jɛ kɛnɛ ta̱a̱ in laa no̱o̱ŋ jɛ kɛ ɣöö bɛ ben nhial kɛnɛ ɣöö bɛ wɔ̱ nhiam.
Kɔnthɛr ka̱nthɛr, mi̱ ŋa̱ckɛ bä cie kɔlɛrɔktal ka̱nthɛr, ɛ ta̱a̱ mi̱ la tuɔɔkɛ kä kɔnthɛr kiɛ rektum, min la tha̱a̱ŋdɛ kä intɛthti̱n in di̱i̱t.
Jɛn laa tuɔɔkɛ ɛ la mi̱ ci̱ rɔ rep mi̱ cɔali̱ pöli̱p, mi̱ dee rɔ re̱p ɛ la kanthɛr kɛ kɔr gua̱th mi̱ bäär.
Kä pathophysiology duŋ kanthɛr duŋ kɔlɔn cuɛ te rɛy ŋɔaani̱ ti̱ ŋuan, cu määni̱ ji̱i̱n mutɛciɔni̱, käpdɛ kɛ̈ɛ̈l, kɛnɛ gua̱th in cieŋ kɛ thi̱n.
Jenetik mutɛciɔni̱ dɔ̱ŋ bi̱ ben raar rɛy DNA duŋ thëlli̱ kɔlɔn, min bi̱ nööŋni̱ pieth thëlli̱ ti̱ /ca luäŋ kɛ ga̱ŋ kɛnɛ dääkdiɛn.
Kɛn mutɛciɔni̱ ti̱ti̱ dëë kɛ jek ɛ raan kiɛ dëë kɛ jek ɛ raan, kä dëë kɛ gɛr kä ji̱i̱ni̱ ti̱ gööl tin te rɛy pieth thëlli̱, da̱a̱kɛ, kɛnɛ riali̱diɛn.
Kɛn jua̱th tin laa tuɔɔmkɛ rɛy puɔ̱ny, tin laa bëë kɛ kui̱ jua̱th ti̱ ciee kɛ jua̱th puɔ̱ny in laa tuɔɔmkɛ rɛy puɔ̱ny, laa kɛ laa jakɛ kä laa tekɛ juey in laa no̱o̱ŋ kɛ juey puɔ̱ny.
Kɔnpa̱mmi̱ciɔn in /ci̱ rɔ luäŋ derɛ nööŋni̱ ka̱mraar kɛ ki̱mi̱kali̱ tin bi̱ pi̱eth thëlli̱ jakä di̱t kɛnɛ dääkdiɛn, min bi̱ ben raar kä kanthɛr.
Kɛn tin laa tä rɛy gua̱th in cieŋ raan thi̱n, cetkɛ mi̱eth in camɛ, ta̱a̱ in cieŋ raan thi̱n, kɛnɛ ɣöö laa raan laa te rɛy kuakni̱ tin laa jakɛ kä jiäk, kɛn diaal laa kɛ laa jakɛ kä laa tekɛ kanthɛr.
Mi̱ cie mi̱ ci̱e mi̱ di̱i̱t kä mi̱th tin ca riali̱kä kɛnɛ tin ca luäŋ kɛ kuën, cäät, ca kɛ mat kɛɛl kɛ ɣöö ba rɔ̱ rep kɛ juey kanthɛr in di̱i̱t.
Kɛn tin kɔ̱ŋ, ce̱tkɛ di̱t pua̱a̱ny, ta̱a̱th, kɛnɛ thil la̱t pua̱a̱ny, de kɛn rɔ̱ rep bä.
Mi̱ ci̱ kanthɛr kɔlön rɔ tok, derɛ räth kɛ dup ti̱ ŋuan, kä kanthɛr in took rɔ min te rɛy kɔlön amäni̱ gua̱th in ci̱ kanthɛr räth kä tha̱a̱ŋ pua̱a̱ny.
Kä thëlli̱ kanthɛr derɛ wä rɛy pua̱a̱nyni̱ tin thia̱k kɛnɛ puɔ̱ny, kä derɛ rɔ däk kɛ rɛy lymphatic thi̱thtɛm kiɛ riɛm ɛ wä gua̱th ti̱ na̱n, ce̱tkɛ ji̱i̱th kiɛ puɔ̱ny.
Kä ta̱a̱ in laa jua̱thkɛ kɛ kɛ laa matkɛ ni̱ la̱t, ki̱möthɛrapi̱, kɛnɛ radi̱i̱thi̱ɛrapi̱, kä nɔmɔ laa bëë kä ta̱a̱ in te kɛ juey kä gua̱a̱th in te thi̱n.
Guäc kɛ gua̱a̱th in took rɔ thi̱n kɛnɛ luäk kɛ jɛ kɛ ɣöö bi̱ jua̱th jakä gɔaa, kɛ ɣöö ɛn kancer colon laa luäŋɛ kɛ luäk mi̱ caa jɛ jek kɛ gua̱a̱th in took rɔ thi̱n.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
['Lät kɛ kui̱i̱ jua̱thni̱']
['Ɛn wɛbthaay ɛmɛ ca la̱th lät kɛ kui̱ ŋi̱i̱cä kɛnɛ läri kä /cɛ lot ni ɣöö ba ji̱ moc kɛ luäk ki̱mä kiɛ lät ti̱ gööl.']
['Lät kɛ läri tin ca ŋun /ca kɛ bi̱ lät kɛ ɣöö ba jua̱th jek kiɛ ba kɛ ciɛŋ, kä nɛy tin görkɛ luäk ki̱mädiɛn kärɔ̱ ba kɛ thiec kä ki̱m mi̱ tekɛ luäk ki̱mä.']
['Guic ɛ gɔaa ɛn ɣöö ɛn neural net min jak luɔc kä thie̱cni̱, /cɛ thuɔ̱k ɛlɔ̱ŋ mi̱ ci̱ ben kä nämbäri̱ tin te thi̱n. cetkɛ pek nath tin ca jek kɛ juey mi̱ rɛlrɔ.']
['Ni ciaŋ go̱ri ruac kä ki̱mdu kiɛ ram in kɔ̱ŋ mi ŋäc luäk pua̱a̱ny kɛ kui̱ jua̱thdu. /Cu ruac ki̱mdu car kiɛ jääny kɛ go̱ri kɛ kui̱ kä mi ci kuɛn kä wɛbthaay ɛmɛ. Mi caari jɛ ɛn ɣöö deri tekɛ juey mi go̱o̱ri luäk, cɔl 911 kiɛ wër guäth in thia̱k kɛ ji kɛ pɛ̈th. /Thilɛ maar kam ki̱m kɛnɛ juey mi bi̱ tuɔɔk kɛ kui̱ kä wɛbthaay ɛmɛ kiɛ la̱tdɛ. /Ci̱ BioMedLib kiɛ la̱a̱tkɛ, kiɛ ram in gɔ̱a̱r kɛ kui̱ kä wɛbthaay ɛmɛ, bi̱ ruac lat, kiɛ bi̱ ruac lat, kɛ kui̱ läri tin ca ka̱m raar rɛydɛ kiɛ la̱tdɛ.']
['Lät kɛ: ŋuɔ̱t']
['Ɛn Digital Millennium Copyright Act 1998, 17 U.S.C. § 512 (ɛ DMCA) ɛ ŋuɔ̱t mi̱ ŋun ji̱ cuŋni̱ tin ŋääth kɛn ɣöö ci̱ ŋɔaani̱ tin te kä intɛrnɛt ŋuɔ̱tkiɛn to̱l kɛ kui̱ ŋuɔ̱tni̱ cuŋni̱ tin te kä U.S.']
['Mi ca ji̱ ŋäth kɛ thuɔ̱k ɛn ɣöö tëëkɛ mi̱ ca gɔ̱r kiɛ mi̱ ca ka̱m ji̱ rɛy wɛbthaayäda kiɛ lät tin kɔ̱ŋ tin ci̱ ŋuɔ̱t tin ca gɔ̱r ya̱r, ji̱n (kiɛ ram in lät kɛ kui̱du) deri̱ kɔ jäk kä warɛgak mi̱ bi̱ ji̱ thiec ɛn ɣöö ba min ca gɔ̱r kiɛ min ca gɔ̱r woc, kiɛ ba duɔ̱ɔ̱r la̱t kɛ ɣöö bi̱ ji̱ cop thi̱n.']
['Kɛn läri̱ ba kɛ jäk kɛ wargak ɛ la i̱thtäm (guic ni̱ gua̱th in ci̱ i̱thtäm in ca gɔ̱r "Kɔntak" kɛ kui̱ i̱thtäm in ci̱ jäk).']
['DMCA go̱o̱rɛ ɣöö bi̱ ji̱n warɛgakdu lat kɛ kui̱ kä tin ca lar i̱ ci̱ ŋuɔ̱t gɛr kɛ kui̱i̱ ŋuɔ̱tni̱ gɔ̱rä mat thi̱n kɛ läär ti̱ti̱: (1) latdɛ kɛ kui̱i̱ la̱t in ca gɛr kɛ kui̱i̱ ŋuɔ̱tni̱ gɔ̱rä min ca lar i̱ ca gɛr; (2) latdɛ kɛ kui̱i̱ kä tin ca lar i̱ ci̱ ŋuɔ̱t gɛr kɛnɛ läär ti̱ ro̱ŋ kɛ ɣöö bi̱ kɔn kɛ jek; (3) läri̱ kɛ kui̱i̱ kä min dëë ji̱ luäk kɛ jek, amäni̱ ci̱ötdu, nämbärɛ kä tin ci̱ ji̱ luäk kɛ jek, kɛnɛ emaildu; (4) latdu kɛ ɣöö ci̱ ji̱n ɛ ŋa̱c ɛn ɣöö min ca gɔ̱r kɛ kui̱i̱ kä tin ca lar /ci̱kɛ bi̱ lät kɛ luäkdɛ ɛ gua̱n ŋuɔ̱tni̱ gɔ̱rä, kiɛ ɛ la̱tdɛ, kiɛ kɛ luäk ŋuɔ̱tni̱; ']
['(5) mi ci ji gɔr piny kɛ kuic kä ɣöö bi ji ruac kɛ thuɔ̱k, ɛn ɣöö läri tin ca gɔr ɛ thuɔ̱k kä te ji kɛ lua̱ŋ kɛ ɣöö bi yiöw tin ca gɔr piny tin ca lar ɛ ji̱n ka̱m raar;']
['kɛnɛ (6) mi̱ ca gɔ̱r piny ɛ gua̱n ŋuɔ̱tni̱ kiɛ ram mi̱ tekɛ lua̱ŋ kɛ lät kɛ kui̱dɛ.']
['Mi /kenɛ läri tin ca lat nhial diaal mat thi̱n dɔ̱ŋ derɛ ku lɛ wɔ̱ jɔ̱ɔ̱r kɛ lätni̱ kɛ kɛ.']
['Röm kɛ jɛ']
['Thiecɛ kɔ kɛ email kɛ thiecni kiɛ cär.']
What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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['Kɔn cua tok kɛ mi̱lli̱ön 35 kä baömedikal publi̱kecin PubMed/Medline. Kä bä, webpage duŋ RefinedWeb.']
