O le pathophysiology o le kanesa o le susu e faasino atu i suiga lē masani i faiga masani o le tino ma auala e tutupu i le atinaʻe ma le alualu i luma o le kanesa o le susu.
E aofia ai le suʻesuʻeina o le auala e tutupu ai sela o le susu ma le auala e sosolo ai sela o le kanesa.
E aofia ai ma vala tau kenera, epigenetic, ma le siʻosiʻomaga e māfua ai le kanesa o le susu.
O nisi o suiga autū o le tino o le tagata i le kanesa o le susu e aofia ai:
1. Fesuiaʻiga o sela o le tino: O suiga i sela o le tino e pei o le BRCA1 ma le BRCA2, e mafai ona faateleina ai le lamatiaga o le maua i le kanesa o le susu.
O nei suiga e mafai ona tuufaasolo mai pe maua mai foʻi a o faagasolo le olaga o se tagata.
2. O le lē paleni o le homone: O homone, aemaise lava le estrogen, e mafai ona aafia ai le tupu aʻe ma le faateleina o le kanesa o le susu.
O le lē paleni o le maualuga o homone po o le tele o le estrogen e mafai ona faateleina ai le lamatiaga o le kanesa o le susu.
3. Fulafula: O le fulafula faaumiumi o sela o le susu e mafai ona māfua ai le kanesa o le susu, ona e faateleina ai sela o le kanesa ma ola ai pea.
4. Vaega o loo siʻomia ai le tuma: O le siʻomaga o loo siʻomia ai le tuma, e aofia ai le vaega o loo i fafo atu o sela, sela e puipuia ai le tino, ma alātoto, e mafai ona aafia ai le tupu aʻe ma le sosolo atu o le kanesa o le susu.
5. Metastasis: O le kanesa o le susu e mafai ona sosolo atu i isi vaega o le tino e ala i le lymphatic system po o le toto, ma oo atu ai i le faia o ni tuma e tutupu i totoga e mamao ese atu.
O le malamalama i le pathophysiology o le kanesa o le susu e tāua tele mo le atinaʻeina o auala e puipuia ai, vave iloa, ma togafitiga.
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Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.
Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
['Faamatalaga: faafomaʻi']
['O lenei upega tafaʻilagi ua saunia mo na o le aʻoaʻoina ma le faailoaina atu o faamatalaga, ae e lē o se fautuaga faafomaʻi po o se auaunaga faapolofesa.']
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['(5) o se faamatalaga mai iā te oe, ua sainia i lalo o le faasalaga o le pepelo, e faapea o faamatalaga o loo i le faasilasilaga e saʻo ma e iai lau pule e faamalosia ai le aiā tatau lea o loo faapea mai ua solia; ']
['ma le (6) saini faaletino po o saini faaeletoroni a lē e ana le aiā tatau po o se tagata ua faatagaina e galue e fai ma sui o lē e ana le aiā tatau. ']
['Afai e lē o aofia uma faamatalaga o loo i luga, e ono faatuai ai ona iloilo lau faitioga.']
['Faafesootaʻi']
['Faamolemole lafo mai se imeli i so o se fesili / fautuaga.']
What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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['Tagaʻi i le "Faamatalaga" ma le "Faamatalaga".']
