Pathophysiology ea kankere ea mala a maholo e bolela mekhoa le mekhoa e ka sehloohong e lebisang ho hlaheng le ho mpefatseng ha kankere ea mala a maholo.
Kankere ea mala a maholo, e tsejoang hape e le kankere ea mala a maholo, ke mofuta oa kankere e qalang ka maleng a maholo kapa a mokokotlo, e leng karolo ea mala a maholo.
Hangata e qala e le ntho e hōlang e bitsoang polyp, e ka' nang ea fetoha kankere ha nako e ntse e e - ea.
Pathophysiology ea kankere ea mala a maholo e akarelletsa lintho tse'maloa, ho akarelletsa liphetoho tsa liphatsa tsa lefutso, ho ruruha le lintho tse amanang le tikoloho.
Liphetoho tsa liphatsa tsa lefutso li ka etsahala DNA ea lisele tsa mala a maholo, e leng se lebisang kholong le ho aroleng lisele tse sa laoleheng.
Liphetoho tsena li ka futsetsoa kapa tsa fumanoa,'me li ka ama liphatsa tse fapaneng tsa lefutso tse etsang hore lisele li hōle, li arohane le ho itokisa.
Ho ruruha ha mala, ho ka bakoang ke maemo a kang lefu la ho ruruha ha mala, le hona ho ka eketsa kotsi ea kankere ea mala.
Ho ruruha ho sa foleng ho ka etsa hore ho ntšoe lik'hemik'hale tse khothalletsang hore lisele li hōle le ho arohana, e leng se ka 'nang sa etsa hore motho a be le kankere.
Lintho tse amanang le tikoloho, tse kang lijo tseo motho a li jang, tsela eo a phelang ka eona le ho pepesehela lik'hemik'hale tse itseng, le tsona li ka baka kankere ea mala.
Ka mohlala, ho ja nama e khubelu le e entsoeng ka nama e ngata ho amahanngoa le ho ba kotsing e eketsehileng ea ho tšoaroa ke kankere ea mala.
Lintho tse ling tse kang ho nona haholo, ho tsuba le ho se ikoetlise, le tsona li ka eketsa kotsi ea ho tšoaroa ke lefu lena.
Hang ha kankere ea mala e se e hlahile, e ka fetela mekhahlelong e'maloa, ho tloha boemong ba pele ba kankere e fumanoang feela ka maleng ho ea ho e tsoetseng pele moo kankere e nametseng likarolong tse ling tsa'mele.
Lisele tsa kankere li ka hlasela lisele le litho tse haufi,'me li ka 'na tsa namela ka mokokotlong kapa maling ho ea libakeng tse hōle, tse kang sebete kapa matšoafo.
Hangata phekolo ea kankere ea mala a maholo e akarelletsa ho buuoa, chemotherapy le radiation therapy, ho itšetlehile ka hore na kankere e boemong bofe le hore e hokae.
Ho lemoha le ho phekola kankere ea mala kapele ke habohlokoa e le hore liphello li ntlafale, kaha hangata kankere ea mala e ka phekoleha ha e lemohuoa e sa le ka nako.
Ho hlahlojoa mala ka mehla, joaloka colonoscopy, ho ka thusa ho lemoha kankere ea mala e sa le ka nako, ha e ka phekoleha habonolo.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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["DMCA e hloka hore tsebiso ea hao ea ho tlōla ha molao ho boleloang hore e na le boitsebiso bo latelang: (1) tlhaloso ea mosebetsi o sirelelitsoeng ka molao o boleloang hore o tlōloa; (2) tlhaloso ea litaba tse boleloang hore li tlōla molao le boitsebiso bo lekaneng ho re lumella ho fumana litaba; (3) boitsebiso ba ho ikopanya le uena, ho akarelletsa aterese ea hau, nomoro ea fono le aterese ea imeile; (4) polelo ea hau ea hore u na le tumelo e ntle ea hore litaba ka tsela e belaelloang ha e lumelloe ke mong'a litokelo tsa molao, kapa moemeli oa eona, kapa ka ts'ebetso ea molao leha e le ofe; "]
['(5) polelo e saennweng ke wena, tlasa kotlo ya ho hlapanya leshano, ya hore tlhahisoleseding e tsebisong e nepahetse le hore o na le matla a ho tiisa ditokelo tsa mongodi tseo ho thweng di a tlolwa; ']
["le (6) ho saena ka letsoho kapa ka elektronike ha mong'a litokelo tsa bangoli kapa motho ea lumeletsoeng ho nka khato lebitsong la mong'a litokelo tsa bangoli. "]
['Ho hloleha ho kenyelletsa tlhahisoleseding yohle e ka hodimo ho ka baka ho dieha ha ho sebetswa tletlebo ya hao.']
['Ho Iteanya']
['Ka kōpo re romelle imeile ka potso / tlhahiso leha e le efe.']
What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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