What causes Colon cancer?

Yini lebangela umdlavuza wemaphaphu?

Umdlavuza wemaphaphu, lophindze watiwe ngekutsi ngumdlavuza wemlomo, ubangelwa kukhula lokungakacondzi kwemaseli langakavami emgconyeni.

Imbangela yeligciwane lengculazi yemaphaphu ayatiwa, kodvwa tintfo letinyenti tingakhulisa bungoti bekutsi ube nalesifo.

Loku kufaka ekhatsi:

1. Budzala: Ingoti yekutsi ube nemdlavuza wemaphaphu iyakhula nawuchubeka ukhula, futsi bantfu labanyenti labanawo baneminyaka lengetulu kwa-50.

2. Umlandvo wemndeni: Umlandvo wemuntfu nobe wemndeni lonesifo semdlavuza wemaphaphu nobe emapholisi, wenta kutsi kube sengotini lenkhulu yekungenwa ngulesifo.

3. Tifo letitfolakala ngekutalwa: Tifo letitsite letitfolakala ngekutalwa, njengesifo lesibitwa ngekutsi yi-familial adenomatous polyposis (FAP) kanye nesifo lesitsatselwanako lesibitwa ngekutsi yi-non-polyposis colorectal cancer (HNPCC), tingenta umuntfu abe sengotini yekungenwa ngumdlavuza wesinye.

4. Indlela yekuphila: Kudla inyama lebovu kanye nenyama leyakhiwe, kukhuluphala, kubhema kanye nekunatsa kakhulu tjwala kungakhulisa ematfuba ekungenwa ngumdlavuza wesinye.

5. Sifo semathumbu lesibangela kuvuvuka: Tifo temathumbu letivame kutsatsa sikhatsi lesidze, njengesifo sematsambo kanye nesifo se-Crohn, tingenta umuntfu abe sengotini yekungenwa ngumdlavuza wemathumbu.

6. Sifo sashukela sesibili: Bantfu labanesifo sashukela sesibili basengotini lenkhulu yekungenwa ngumdlavuza wesinye.

7. Kwelashwa ngemisebe: Kwelashwa ngemisebe yaletinye tifo temdlavuza esiswini kungakhulisa ingoti yekutsi ube nemdlavuza wemaphaphu.

8. Buve: Bantfu labamnyama baseMelika basengotini lenkhulu yekungenwa ngumdlavuza wemaphaphu kunebantfu baletinye tive.

Kubalulekile kwati kutsi kuba nayinye nobe ngetulu yaletintfo letiyingoti akusho kutsi umuntfu utawuba nemdlavuza wesinye, kantsi labanye bantfu labanemdlavuza wesinye kungenteka bangabi nato tintfo letiyingoti.

Kuhlolwa njalo kanye nekutfola kutsi unaso yini kungavikela kutsi ungabi naso nobe kusheshe kukubone nangabe sekulula kuselapha.

['Tintfo letibhalwe phansi']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

McWhirter JE, Todd LE, Hoffman-Goetz L: Beliefs about causes of colon cancer by English-as-a-Second-Language Chinese immigrant women to Canada. J Cancer Educ. 2011, 26 (4): 734-9.

Gamble JF: Asbestos and colon cancer: a weight-of-the-evidence review. Environ Health Perspect. 1994, 102 (12): 1038-50.

Ashish S, Raj M: Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden. Cureus. 2022, 14 (3): e22894.

Xu W, Zhang Y, Chen L, Qiu F, Zhang B, Wu L, Peng Z, Tang H: Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget. 2017, 8 (42): 71954-71964.

Wang J, Wu HF, Shen W, Xu DY, Ruan TY, Tao GQ, Lu PH: SRPK2 promotes the growth and migration of the colon cancer cells. Gene. 2016, 586 (1): 41-7.

Taketo MM, Edelmann W: Mouse models of colon cancer. Gastroenterology. 2009, 136 (3): 780-98.

Slattery ML, Kerber RA: The impact of family history of colon cancer on survival after diagnosis with colon cancer. Int J Epidemiol. 1995, 24 (5): 888-96.

['Sitatimende: setekwelapha']

['Lelikhasi langcondvomshini liniketelwe kufundzisa nekwatisa kuphela futsi alitsatsi seluleko setekwelapha nobe umsebenti wetingcweti.']

['Lemininingwane leniketwako akukafaneli isetjentiselwe kutfola nobe kwelapha tinkinga temphilo nobe tifo, futsi labo labafuna lusito lwetekwelapha kufanele batsintse dokotela lonemvume yekwenta njalo.']

['Uyacelwa kutsi ucaphele kutsi luhlelo lwekuchumana lolwakha timphendvulo temibuto, alukabi kahle kakhulu uma kukhulunywa ngetinombolo. Sibonelo, sibalo sebantfu labanesifo lesitsite.']

['Ngaso sonkhe sikhatsi cela seluleko kudokotela wakho nobe lomunye loniketa lusito lwetemphilo mayelana nesimo sakho sekugula. Ungalokotsi unganaki seluleko sebucwepheshe nobe wephute kusitfola ngenca yalokutsite lokufundze kulewebhusayithi. Uma ucabanga kutsi kungenteka unekugula, shayela 911 nobe uye egunjini lelisedvute lekuphutfuma ngekushesha. Kute budlelwane emkhatsini wetekwelapha nesigulane lobentiwa ngulewebhusayithi nobe kusetjentiswa kwayo. I-BioMedLib nobe basebenti bayo, nobe ngumuphi umuntfu lofaka sandla kulewebhusayithi, akenti nobe nguyiphi imiculu, lechazako nobe lechazako, mayelana nemniningwane loniketwe lapha nobe kusetjentiswa kwayo.']

['Liciniso: copyright']

['Umtsetfo we-Digital Millennium Copyright Act wanga-1998, 17 U.S.C. § 512 (i-DMCA) uniketa indlela yekusitwa kubanikati bemalungelo ekushicilela labakholelwa kutsi tintfo letivela ku-Internet tiphula emalungelo abo ngaphansi kwemtsetfo we-U.S. wekushicilela. ']

['Nangabe ukholelwa kutsi nobe nguyiphi intfo nobe intfo lekhona kulewebhusayithi nobe etinhlelweni tetfu yephula emalungelo akho, wena (nobe ummeli wakho) ungasitfumelela satiso ucele kutsi leyo nto nobe intfo isuswe nobe ivinjelwe.']

['Tatiso kumele titfunyelwe nge-email (buka likheli le-email kusigaba "Sekuchumana").']

['I-DMCA idzinga kutsi satiso sakho sekuhlukumeta emalungelo eluntfu sicukatse lemininingwane lelandzelako: (1) inchazelo yemsebenti logunyatwe emalungelo eluntfu lokutsiwa uphasiwe; (2) inchazelo yalokucuketfwe lokutsiwa kuphasiwe kanye nemininingwane leyenele kutsi sikhone kutfola lokucuketfwe; (3) imininingwane yekutsintsana nawe, kufaka ekhatsi likheli lakho, inombolo yelucingo nelikheli le-email; (4) sitatimende sakho sekutsi unenkolelo lenhle yekutsi lokucuketfwe ngendlela lokhonjiwe akukavumeleki kumnikati wemalungelo eluntfu, nobe kummeli wakhe, nobe ngekusebenta kwanoma ngumuphi umtsetfo; ']

['(5) sitatimende sakho, lesisayinwe ngaphasi kwesijeziso sekufunga emanga, sekutsi umniningwane lokuso satiso ucinisile nekutsi uneligunya lekuvikela emalungelo e-copyright lasolwa kutsi ephuliwe;']

['kanye (6) nekusayina ngekwemtimba nobe nge-elekthroniki kwemnikati we-copyright nobe umuntfu logunyatiwe kutsi ente umsebenti egameni lemnikati we-copyright. ']

['Kwehluleka kufaka yonkhe lemininingwane lengenhla kungaholela ekubambelekeni kwekusetjentwa kwesikhalo sakho.']

['Kuchumana']

['Sicela usitfumelele i-email nganobe nguwuphi umbuto / umbono.']

What causes colon cancer?

Colon cancer, also known as colorectal cancer, is caused by the uncontrolled growth of abnormal cells in the colon or rectum.

The exact cause of colon cancer is not known, but several factors can increase the risk of developing the disease.

These include:

1. Age: The risk of colon cancer increases with age, with most cases occurring in people over the age of 50.

2. Family history: A personal or family history of colon cancer or polyps increases the risk of developing the disease.

3. Inherited syndromes: Certain inherited genetic syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), can increase the risk of colon cancer.

4. Lifestyle factors: A diet high in red and processed meats, obesity, smoking, and excessive alcohol consumption can increase the risk of colon cancer.

5. Inflammatory bowel disease: Long-term inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, can increase the risk of colon cancer.

6. Type 2 diabetes: People with type 2 diabetes have an increased risk of developing colon cancer.

7. Radiation therapy: Radiation therapy for other cancers in the abdomen can increase the risk of colon cancer.

8. Race: African Americans have a higher risk of developing colon cancer than other races.

It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop colon cancer, and some people who develop colon cancer may not have any known risk factors.

Regular screening and early detection can help prevent colon cancer or detect it at an early stage when it is most treatable.

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